Human peripheral blood mononuclear cells stimulated by Schistosoma mansoni antigens: association between protein tyrosine kinases, mitogen-activated protein kinases and cytokine production

Almeida, Célia A; Góes, Alfredo M.

doi:10.1016/s1383-5769(99)00027-6

Cited by 10 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This interaction has long been thought to modify host cellular homeostasis and contribute to malignant transformations 58, 59 . Secretions of other infectious agents have supported this notion: H. pylori causes cell proliferation through protein transfer, and schistosome secretions and tapeworm soluble products induce hyperplasia 60–63 . A routine observation in fluke infections is altered cell states, one of the gateways to genomic instability that can be induced by a variety of growth factors 64 .…”

Section: Mechanisms Of Opisthorchis Viverrini-initiated Ccamentioning

confidence: 99%

“…58,59 Secretions of other infectious agents have supported this notion: H. pylori causes cell proliferation through protein transfer, and schistosome secretions and tapeworm soluble products induce hyperplasia. [60][61][62][63] A routine observation in fluke infections is altered cell states, one of the gateways to genomic instability that can be induced by a variety of growth factors. 64 Lesions of epithelial dysplasia and metaplasia including goblet cell metaplasia and adenomatous hyperplasia are commonly seen.…”

Section: Mitogenic Properties Of Fluke Es Productsmentioning

confidence: 99%

See 1 more Smart Citation

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini

et al. 2011

View full text Add to dashboard Cite

Summary Throughout Southeast Asia there is a strikingly high incidence of cholangiocarcinoma (CCA - hepatic cancer of the bile duct epithelium), particularly in people from rural settings in Laos and Northeast Thailand who are infected with the liver fluke, Opisthorchis viverrini, one of only three carcinogenic eukaryotic pathogens. More ubiquitous carcinogenic microbes, such as Helicobacter pylori, induce cancer in less than 1% of infected people, while as many as one-sixth of people with opisthorchiasis will develop CCA. The mechanisms by which O. viverrini causes cancer are multi-factorial, involving mechanical irritation from the activities and movements of the flukes, immunopathology, dietary nitrosamines and the secretion of parasite proteins that promote a tumourigenic environment. Genomic and proteomic studies of the liver fluke secretome have accelerated the discovery of parasite proteins with known/potential roles in pathogenesis and tumourigenesis, establishing a framework towards understanding, and ultimately preventing, the morbidity and mortality attributed to this highly carcinogenic parasite.

show abstract

Section: Mechanisms Of Opisthorchis Viverrini-initiated Ccamentioning

confidence: 99%

Section: Mitogenic Properties Of Fluke Es Productsmentioning

confidence: 99%

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The release of cytokines such as IL-4, IL-5, IL-10, and IL-13 is a hallmark of the egg-induced granulomatous host immune response driven by Type 2 lymphocytes [77]. S. mansoni antigen-induced cytokine production [78], T-cell proliferation, and in vitro granuloma formation involve the activation of protein tyrosine kinases (PTKs) and protein kinase C (PKC) [79]. It has been speculated that immunomodulation might either influence PTKs activity or be the result of altered PTK regulation [80].…”

Section: Hepatic Schistosomiasismentioning

confidence: 99%

Does Schistosoma Mansoni Facilitate Carcinogenesis?

Bülow

Lichtenberger

Grevelding

et al. 2021

Cells

View full text Add to dashboard Cite

Schistosomiasis is one of the most prominent parasite-induced infectious diseases, causing tremendous medical and socioeconomic problems. Current studies have reported on the spread of endemic regions and the fear of development of resistance against praziquantel, the only effective drug available. Among the Schistosoma species, only S. haematobium is classified as a Group 1 carcinogen (definitely cancerogenic to humans), causing squamous cell carcinoma of the bladder, whereas infection with S. mansoni is included in Group 3 of carcinogenic hazards to humans by the International Agency for Research on Cancer (IARC), indicating insufficient evidence to determine its carcinogenicity. Nevertheless, although S. mansoni has not been discussed as an organic carcinogen, the multiplicity of case reports, together with recent data from animal models and cell culture experiments, suggests that this parasite can predispose patients to or promote hepatic and colorectal cancer. In this review, we discuss the current data, with a focus on new developments regarding the association of S. mansoni infection with human cancer and the recently discovered biomolecular mechanisms by which S. mansoni may predispose patients to cancer development and carcinogenesis.

show abstract

“…However, the transmembrane signalling mechanisms triggered by S. mansoni antigens and the biochemical changes in response to TCR activation are not completely understood. The inhibition of protein kinases prevents proliferation of PBMC from schistosomiasis patients in response to SEA or SWAP [14]. Other authors [15, 16] showed that general immune response hyporesponsiveness in activated individuals was manifested by attenuated or lack of early transmembrane signalling and phosphorylation of downstream kinases, such as ERK1/2 and p38, suggesting malfunction of both kinases and phosphatases.…”

Section: Introductionmentioning

confidence: 99%

CD4⁺ and CD8⁺ Distribution Profile in Individuals Infected by Schistosoma mansoni

et al. 2009

View full text Add to dashboard Cite

Rationale: Patients with chronic Schistosoma mansoni infection show lower anti‐soluble egg antigen (SEA) proliferation responses and higher responses to soluble worm antigen preparation (SWAP). Objective: To compare the activation status and proliferation response of peripheral blood mononuclear cells (PBMC) of infected (XTO) and egg‐negative individuals (NI) living in the same endemic area. Methods: XTO (n = 51) and NI individuals from the same geographical area (n = 37) and healthy blood donors (n = 22) were evaluated before and after stimulation with SEA and SWAP. The expression of activation markers (CD4+ HLADR+, CD8high+HLA‐DR+ and CD8+ CD28+) and proliferation assay was assessed by flow cytometry. Findings: PBMC from infected patients showed lower frequency of CD4+ but no change in CD8+ T cells when compared with the healthy donor group. The ratio CD4+/CD8+ was 1.3, 0.6 and 0.5 in healthy donors, infected and non‐infected individuals, respectively. The HLA‐DR+ expression on CD8+ was higher in PBMC from infected and non‐infected individuals than from healthy donors, but similar in both total lymphocytes and CD4+ populations. No intergroup proliferation response differences were observed in CD4+ and CD8+ PBMC unstimulated and stimulated with SEA and SWAP. The SEA but not SWAP‐stimulated cells showed a decrease in the expression of phosphorylated extracellular signal‐regulated kinase (ERK1/2). Conclusions: XTO and NI individuals living in the same area presented a smaller per cent of CD4+ and a higher per cent of CD8+ cells. The activation by either CD8high+HLA‐DR+ or CD8high+HLA‐DR+/CD8+ was enhanced and decreased in XTO and NI by CD8+ CD28+ and CD8+ CD28+/CD8+ when compared with healthy donor. ERK phosphorylation was attenuated in XTO and NI individuals when stimulated with SEA but not SWAP.

show abstract

Human peripheral blood mononuclear cells stimulated by Schistosoma mansoni antigens: association between protein tyrosine kinases, mitogen-activated protein kinases and cytokine production

Cited by 10 publications

References 30 publications

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini

Does Schistosoma Mansoni Facilitate Carcinogenesis?

CD4⁺ and CD8⁺ Distribution Profile in Individuals Infected by Schistosoma mansoni

Contact Info

Product

Resources

About

Human peripheral blood mononuclear cells stimulated by Schistosoma mansoni antigens: association between protein tyrosine kinases, mitogen-activated protein kinases and cytokine production

Cited by 10 publications

References 30 publications

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini

Does Schistosoma Mansoni Facilitate Carcinogenesis?

CD4+ and CD8+ Distribution Profile in Individuals Infected by Schistosoma mansoni

Contact Info

Product

Resources

About

CD4⁺ and CD8⁺ Distribution Profile in Individuals Infected by Schistosoma mansoni