Does Schistosoma Mansoni Facilitate Carcinogenesis?

Bülow, Verena von; Lichtenberger, Jakob; Grevelding, Christoph G.; Falcone, Franco H.; Roeb, Elke; Roderfeld, M

doi:10.3390/cells10081982

Cited by 20 publications

(16 citation statements)

References 146 publications

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“…It is important to note, however, that the available data regarding the precise role of S. mansoni in the process of carcinogenesis are conflicting and often lack conclusive evidence of causality. This underscores the need for further comprehensive research to elucidate the intricate relationship between this parasitic infection and the development of hepatic disorders ( 92 ).…”

Section: Resultsmentioning

confidence: 99%

Schistosoma mansoni infection induces hepatic metallothionein and S100 protein expression alongside metabolic dysfunction in hamsters

Ghezellou,

von Bülow,

Luh

et al. 2024

PNAS Nexus

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Schistosomiasis, a widespread neglected tropical disease, presents a complex and multifaceted clinical-pathological profile. Using hamsters as final hosts, we dissected molecular events following Schistosoma mansoni infection in the liver - the organ most severely affected in schistosomiasis patients. Employing TMT-based proteomics, we studied alterations in the liver proteins in response to various infection modes and genders. We examined livers from female and male hamsters that were: non-infected (control), infected with either unisexual S. mansoni cercariae (single-sex), or both sexes (bisex). The infection induced upregulation of proteins associated with immune response, cytoskeletal reorganization, and apoptotic signaling. Notably, S. mansoni egg deposition led to the downregulation of liver factors linked to energy supply and metabolic processes. Gender-specific responses were observed, with males showing higher susceptibility, supported by more differentially expressed proteins than females. Of note, Metallothionein-2 and S100a6 proteins exhibited substantial upregulation in livers of both genders, suggesting their pivotal roles in the liver's injury response. Immunohistochemistry and RT-qPCR confirmed strong upregulation of Metallothionein-2 expression in the cytoplasm and nucleus upon the infection. Similar findings were seen for S100a6, which localized around granulomas and portal tracts. We also observed perturbations in metabolic pathways, including downregulation of enzymes involved in xenobiotic biotransformation, cellular energy metabolism and lipid modulation. Furthermore, lipidomic analyses through LC-MS/MS and MALDI-MSI identified extensive alterations, notably in cardiolipin and triacylglycerols, suggesting specific roles of lipids during pathogenesis. These findings provide unprecedented insights into the hepatic response to S. mansoni infection, shedding light on the complexity of liver pathology in this disease.

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Section: Resultsmentioning

confidence: 99%

Schistosoma mansoni infection induces hepatic metallothionein and S100 protein expression alongside metabolic dysfunction in hamsters

Ghezellou,

von Bülow,

Luh

et al. 2024

PNAS Nexus

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“…Artemisinin (12, Figure 3) and its congeners are the active ingredients in the extracts of Artemisia annua, which have been used as traditional Chinese medicine for a variety Oxamniquine (OXA) and related compounds (6)(7)(8)(9)(10)(11).…”

Section: Antischistosomal Antimalarials 41 Artemisininsmentioning

confidence: 99%

“…Chronic schistosomiasis is associated with diseases of the kidneys, spleen, liver, bladder and intestine [3]. In endemic areas, up to 75% of the incidence of bladder cancer has been attributed to infection with S. haematobium; [4,5] the link between S. mansoni infection and cancer is still being investigated [6]. In all, the global burden due to schistosomiasis, in terms of disability-adjusted life years (DALYs, which combine premature mortality data with years lived with a disability) has been estimated at 1.7-4.5 million [7].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Anti-Schistosomiasis Drug Discovery

Marker¹,

Debbert²

2022

Parasitic Helminths and Zoonoses - From Basic to Applied Research

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Schistosomiasis, a parasitic disease caused by infection by helminths of the Schistosoma genus, affects over 200 million people, primarily in the developing world. Treatment of this disease largely relies on one drug, praziquantel. Although this drug is cheap, safe, and effective, the looming prospect of drug resistance makes the development of a pipeline of anti-schistosomiasis drugs a priority. Many new drug leads have arisen from screening existing sets of compounds such as the Open Access Boxes developed by the Medicines for Malaria Venture (MMV) in collaboration with the Drugs for Neglected Diseases Initiative (DNDI). Other leads have been found through work focused on druggable targets such as kinases, histone deacetylases, proteases, and others. This chapter will discuss recent work concerning the discovery and development of novel anti-schistosomiasis drug leads from many sources.

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“…The studies have shown that it is closely related to schistosomal infection [1,2] . Human schistosomiasis manifests in three main types: S.haematobium S.mansoni and S.japonicum [3,4] , mainly schistosomiasis japonica in China. It is a parasitic disease widely prevalent along the Yangtze River Basin.…”

Section: Introductionmentioning

confidence: 99%

A retrospective cross-sectional study ： comparison of the clinicopathological features with schistosomal and non-schistosomal colorectal cancer in Central China

Zhu,

Wu,

Ran

et al. 2024

Preprint

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Aim To analyze the clinicopathological features of schistosomal and non-schistosomal colorectal cancer in Central China and compare them with other areas of the Yangtze River Basin. Method The 501 cases of CRC were retrospectively analyzed from 2020 to 2022. They were divided into two groups: 406 cases of colorectal cancer without schistosomiasis (CRC-NS) and 95 cases of colorectal cancer with schistosomiasis (CRC-S). The clinicopathological characteristics included the distribution of schistosomiasis eggs, patient age, sex, tumor differentiation, lymph node metastasis, and clinical stage, etc. By retrieving the database, we compared the clinicopathological differences of colorectal cancer with schistosomiasis in other areas of the Yangtze River basin. Results Colorectal cancer with schistosomiasis infection accounted for 18.9%. CRC-S patients were significantly older than CRC-NS patients (P < 0.05). There was a statistical difference in the location of occurrence (P < 0.05) between the two groups. There were no significant differences between CRC-S and CRC-NS patients in other clinicopathological features (P > 0.05). In other areas of the Yangtze River Basin, there were statistical differences in the age of occurrence and T stage (P < 0.05) between colorectal cancer with schistosomiasis and non-schistosomal colorectal cancer. Conclusion In Central China, colorectal cancer with chronic schistosomiasis infection occurs more in the rectum and sigmoid colon. It is more common in individuals over 60 years old, consistent with the findings in the Yangtze River Basin. Additionally, schistosomal colorectal cancer had a higher TNM stage in the Yangtze River Basin. This may be related to the malignant biological behavior of colorectal cancer and could result in a relatively poor prognosis. Therefore, the elderly population in schistosomiasis endemic areas should pay more attention to early screening and tumor prevention.

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Does Schistosoma Mansoni Facilitate Carcinogenesis?

Cited by 20 publications

References 146 publications

Schistosoma mansoni infection induces hepatic metallothionein and S100 protein expression alongside metabolic dysfunction in hamsters

Schistosoma mansoni infection induces hepatic metallothionein and S100 protein expression alongside metabolic dysfunction in hamsters

Recent Advances in Anti-Schistosomiasis Drug Discovery

A retrospective cross-sectional study ： comparison of the clinicopathological features with schistosomal and non-schistosomal colorectal cancer in Central China

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