Human papillomavirus prevalence and distribution in self‐collected samples from female university students in Maputo

Bule, Yara Priscilla; Silva, Jani; Carrilho, Carla; Campos, Carla Cristian; Sousa, Hugo; Tavares, Ana; Medeiros, Rui

doi:10.1002/ijgo.13126

Cited by 9 publications

(11 citation statements)

References 55 publications

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“…One study also found a higher prevalence among WLHIV (26% HIV-positive, 12% HIV-negative) [ 15 ]. However, both found lower prevalences than this study [ 15 , 19 ]. The higher prevalence in this study may be due to geographic variability, differences in HPV specimen collection, or differences in HPV assay sensitivity.…”

Section: Discussioncontrasting

confidence: 87%

HPV prevalence among young adult women living with and without HIV in Botswana for future HPV vaccine impact monitoring

et al. 2022

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Introduction In 2015, Botswana introduced quadrivalent human papillomavirus (HPV) vaccine for girls aged 9–13 years. To establish a baseline HPV prevalence for future HPV vaccine impact monitoring, we evaluated HPV prevalences among the youngest unvaccinated women in Botswana and compared HPV prevalences among women living with HIV (WLHIV) and without HIV. Methods Women aged 18–22 years were recruited from the University of Botswana and HIV clinics in Gaborone from October 2019–January 2021. Demographic and behavioral characteristics were self-reported during structured interviews; HIV clinical characteristics were abstracted from medical charts. Self-collected vaginal swabs were tested for 28 HPV types using Seegene Anyplex II HPV28. We compared prevalence of any HPV, high risk (HR)-HPV, and quadrivalent HPV vaccine types (HPV6/11/16/18) among WLHIV and women without HIV and evaluated risk factors for prevalence of HR-HPV. Results A total of 306 WLHIV and 500 women without HIV were recruited. Compared to women without HIV, WLHIV were more likely to be sexually experienced (86.6% versus 74.4%) and have ≥ 3 lifetime sex partners (55.3% versus 27.8%). All HPV type prevalences were significantly higher among WLHIV compared to women without HIV, including prevalence of any HPV (82.7% versus 63.0%), HR-HPV (72.9% versus 53.8%), and quadrivalent vaccine HPV types (34.3% versus 21.0%). Among WLHIV, there were no differences between those perinatally and non-perinatally infected for HPV prevalences, number of HPV types detected, CD4 count, or viral load. Conclusions Over one-third of WLHIV and nearly a quarter of those without HIV had vaccine-type HPV detected. This study supports need for the national HPV vaccination program in Botswana and provides important baseline data for future evaluation of impact of the program.

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Section: Discussioncontrasting

confidence: 87%

HPV prevalence among young adult women living with and without HIV in Botswana for future HPV vaccine impact monitoring

et al. 2022

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“…HPV66 was recently reported to also have a high prevalence in low-grade cervical lesions of women from Mexico City (45.7%); the prevalence was lower in CC samples (3.6%), although they used a different detection method (INNO-LiPA) [ 52 ]. HPV66 has also been frequently found in Chile [ 53 ], Africa [ 54 , 55 ] and China [ 56 ], among others.…”

Section: Discussionmentioning

confidence: 99%

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

et al. 2020

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Background Human papillomavirus infection is an important factor associated with cervical cancer (CC) development. The prevalence and genotype distribution vary greatly worldwide. Examining local epidemiological data constitutes an important step towards the development of vaccines to prevent CC. In this work, we studied the prevalence of HPV genotypes in women from Western Mexico with the COBAS 4800 and/or Linear Array Genotyping Test (LA). Methods The samples analysed in this study represent a population from Western Mexico, which includes six different states. Our approach was first to test for HPV in cervical samples from women who attended their health clinic for routine gynaecological studies (open-population, n = 3000) by utilizing COBAS 4800. Afterwards, 300 of the HPV-positive samples were randomly selected to be genotyped with LA; finally, we genotyped samples from women with cervical intraepithelial neoplasia grade 1 (CIN 1, n = 71) and CC (n = 96) with LA. Sociodemographic data of the diverse groups were also compared. Results The overall HPV prevalence among the open-population of women as determined by COBAS 4800 was 12.1% (n = 364/3000). Among the HPV-positive samples, single infections (SI) with HPV16 were detected in 12.4% (n = 45/364), SI with HPV18 were detected in 1.4%, and infection with at least one of the genotypes included in the high-risk HPV pool was detected in 74.5% of the cases. LA analysis of the samples showed that in addition to HPV genotypes 16 and 18, there was a high prevalence of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico. With respect to the sociodemographic data, we found statistically significant differences in the number of pregnancies, the use of hormonal contraceptives and tobacco intake. Conclusions Our data indicate that there is a high prevalence of HPV genotypes which are not covered by the vaccines currently available in Mexico; therefore, it is necessary to include HPVs 59, 66, 51, 39 and 56 in the design of future vaccines to reduce the risk of CC development. It is also essential to emphasize that the use of hormonal contraceptives and tobacco smoking are risk factors for CC development in addition to the presence of HPV.

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“…In a study published in 2004 on cervical cancer in Mozambique the dominant HPV types were 16 and 18, being present in 69% of tumours [38]. In a later study published in 2011 on HPV types in cervical cancers in Mozambique HPV 16 and 18 were the most common types detected in cervical cancer biopsies (among both HIV-negative and HIV-positive women) [39,40].…”

Section: Discussionmentioning

confidence: 99%

Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

Maueia

Murahwa

Manjate

et al. 2021

Viruses

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Background: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; p = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found.

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Human papillomavirus prevalence and distribution in self‐collected samples from female university students in Maputo

Cited by 9 publications

References 55 publications

HPV prevalence among young adult women living with and without HIV in Botswana for future HPV vaccine impact monitoring

HPV prevalence among young adult women living with and without HIV in Botswana for future HPV vaccine impact monitoring

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

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