Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Kato, Seeta; Kawai, Ryoko; Isomura, Madoka; Sato, Nobuaki; Yoshida, Waka; Kamiya, Kei; Nagaya, Yoshitaka; Hattori, T; Sato, Emiko; Sugita, Yoshihiko; Kubo, Katsutoshi; Maeda, Hideaki

doi:10.2485/jhtb.24.181

Cited by 5 publications

(11 citation statements)

References 43 publications

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“…As early as 1987, the correlation between HPV and OLP was reported (11), but many studies were conducted after presenting different prevalence rates of HPV in this lesion. In this field, the findings of the present study, indicating the presence of 25% of HPV DNA, might be comparable to the results of some other studies (15)(16)(17)(18)(19)(20)(21)(22), which reported an HPV incidence rate of 15.4% to 42.6% for OLP and 0% to 7% for normal mucosa samples. However, lower incidence rates of 0.02% and 0.32% were also reported by Arirachakaran et al (35) and Szarka et al (36), respectively.…”

Section: Discussionsupporting

confidence: 91%

“…However, comparing the given subtypes, our findings would be comparable to studies conducted by O. flatharta et al (15) and Campisi et al (16), with a report of the most frequent subtypes, i.e., HPV-16 and HPV-33. However, in studies carried out by Kato et al (17) and Vasper et al (18), in addition to subtypes 16 and 33, other subtypes, including subtypes 31 and 18, were detected. Furthermore, Jontell et al (19) showed the presence of HPV-6 and HPV-16 in the erosive form of OLP; Sahebjamiee et al (20) detected subtypes of HPV-16 and HPV-18, and Siribang-on (22) reported that the most frequent subtypes were 16, 18, and 33.…”

Section: Discussionmentioning

confidence: 87%

“…Many researchers have studied the pathogenesis of HPV in OLP lesions and reported different findings of the prevalence of this virus and its subtypes in this lesion (15)(16)(17)(18)(19)(20)(21)(22)(23)(24). In one study published before 1998, 107 OLP samples were studied, 23% of which were HPV-positive.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Human Papillomavirus 33 in Erosive Oral Lichen Planus

et al. 2020

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Background: A correlation is suggested between oral lichen planus (OLP) and the human papillomavirus (HPV) with possible malignant transformation potential in OLP. Objectives: The present study aimed at evaluating the prevalence of HPV-16 and HPV-18 as the most recognized oncogenic subtypes and relatively recently introduced subtype HPV33 in OLP samples. Methods: This retrospective study was carried out on 32 OLP samples (consisting of 12 reticular and 20 erosive forms) and 20 healthy oral mucosa samples. Polymerase chain reaction (PCR) was undertaken to identify HPV Deoxyribonucleic Acid (DNA). Subsequently, the samples positive for HPV DNA underwent PCR analysis again with the specific primers. The data were analyzed statistically by Fisher’s exact test regarding the significance level of lower than 0.05. Results: Eight out of 32 OLP samples (25%) and none of the 20 normal mucosa samples (0%) exhibited HPV DNA. The presence of HPV in the OLP group was significantly higher than that in the normal mucosa (P = 0.014). Also, all the samples that exhibited HPV DNA were registered as the erosive form. Besides, one sample (3.12%) exhibited the 873-bp band, which was attributed to HPV-18, and 7 samples (21.87%) exhibited the 300-bp band, which was attributed to HPV-33. Conclusions: Based on the recent findings in the current study of the Iranian population, the presence of high-risk HPV subtypes, whether primarily or as a secondary infection, can suggest the malignant transformation potential for the studied OLP samples. The exclusive presence of these subtypes in the erosive type of this lesion and the noticeable presence of HPV-33 might reflect this issue’s importance. However, further studies are necessary to evaluate the possibility of a higher proliferation rate of HPV in erosive lichen planus and identify its possible malignant transformation mechanism.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 87%

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Detection of Human Papillomavirus 33 in Erosive Oral Lichen Planus

et al. 2020

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“…[ 13 ] In a 10-year follow-up, the risk of oncogenesis of OLP ranges from 1.2% to 3.2%. [ 14 ] In contrast, Ma et al . [ 1 ] stated that the malignant transformation rate of OLP was 0–6.25%.…”

Section: Discussionmentioning

confidence: 99%

PCR-based Evaluation of Human Papillomavirus Genotypes in Oral Lichen Planus

Vijayan

Muthukrishnan

Nair

et al. 2022

Journal of Pharmacy and Bioallied Sciences

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Objective: The objective of the study was to use polymerase chain reaction (PCR) to examine and compare the genotype distribution of human papillomavirus (HPV) in oral lichen planus (OLP). Materials and Methods: Deoxyribonucleic acid (DNA) was extracted from 20 OLP biopsy specimens. Conventional PCR assay employing consensus HPV primers was used to identify HPV DNA. Positive PCR samples were then subjected to PCR assay with HPV type-specific primers. Results: Out of the total 20 OLP specimens evaluated, eight samples (40%) were positive for HPV. Females had a 41.7% higher HPV-positive rate than males. The most common type in the HPV type-specific PCR assay was HPV-18 (75%), which is a high-risk type of HPV linked to malignant diseases. The erosive kind of OLP had the greatest percentage of HPV positives (50%). Conclusion: The present study confirms the detection of HPV in OLP lesions, as determined by PCR-coupled HPV gene sequencing, as well as its likely mechanism of malignant transformation.

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“…Recent studies have shown that oral infection with HPV is associated with a significant risk of developing oropharyngeal cancer (OPSCC) 14,15) . There is also a potentially important causal association between HPV, OSCC and oral potentially malignant disorders (OPMD), as reported in a systematic review 8) .…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Type 16 Infection and Local Lymph Node Metastasis in Patients with Squamous Cell Carcinoma

Kawai

Isomura

Sato

et al. 2016

J. Hard Tissue Biology.

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Human papillomavirus (HPV) infection is known to be an independent etiologic factor for oral squamous cell carcinoma (OSCC). Especially, HPV-16 is associated with a significant risk of developing OSCC. The most important prognostic factor in OSCC is local lymph node metastasis (LNM); therefore, knowledge of LNM status is crucial for selecting proper treatment plans. However, it is not clarify relationship between HPV-16 infection and LNM in OSCC. The purpose of this study was to determine the role of HPV-16 infection in LNM in OSCC. We analyzed 130 cases of OSCC (100 cases of OSCC without LNM; 30 cases of OSCC with LNM). HPV-16 infection was detected by PCR, immunohistochemical examination and in situ hybridization. HPV-16 positivity rates among primary tumor (PT) specimens without LNM were 43.0 % (43/100), and HPV-16 positivity rates among PT specimens with LNM were 26.7 % (8/30). In addition, HPV-16 positivity rates in both PT and LNM specimens in 30 OSCC patients with LNM were 10 % (3/30). OSCC with HPV-16 DNA detected by PCR showed positive staining on immunohistochemical examination and in situ hybridization. The HPV-16 infection rate in OSCC with LNM was significantly lower than that for OSCC without LNM. In the case of OSCC with LNM, HPV-16 infection rates for both in PT and LNM were low. This suggests that HPV-16 positive cases had a significantly lower risk of LNM when compared with patients having HPV-16 negative OSCC. The results of the present study suggest that HPV status in OSCC is able to act as a marker for risk of LNM.

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Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Cited by 5 publications

References 43 publications

Detection of Human Papillomavirus 33 in Erosive Oral Lichen Planus

Detection of Human Papillomavirus 33 in Erosive Oral Lichen Planus

PCR-based Evaluation of Human Papillomavirus Genotypes in Oral Lichen Planus

Human Papillomavirus Type 16 Infection and Local Lymph Node Metastasis in Patients with Squamous Cell Carcinoma

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