Human papillomavirus (HPV) genotype distribution in women with abnormal cervical cytology in the Basque Country, Spain

Delgado, Diego; Marín, Juan Manuel Arribas; Diego, Julia de; Guerra, S.; Gonzalez, B.; Barrios, José Luís González; Canut, Andrés

doi:10.1016/j.eimc.2011.10.021

Cited by 15 publications

(22 citation statements)

References 34 publications

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“…Although the prevalence and distribution of HPV genotypes vary greatly around the world, our data are similar to those reported by Delgado et al [17]. That group conducted an epidemiological study in Spanish women with an abnormal cytological diagnosis, using the same molecular identification system as ours.…”

Section: Discussionsupporting

confidence: 78%

“…Different studies [10,17] have suggested that HPV infection is most common in young women and that the likelihood of infection decreases with increasing age. It has been proposed that this situation can be due to the concept that in women over 30 years of age the proportion of transient infections is decreased and they develop cell-mediated immunity against viral genotypes [12] or reach stability in terms of their sex partner, which generally occurs in old age [21].…”

Section: Discussionmentioning

confidence: 99%

“…That group conducted an epidemiological study in Spanish women with an abnormal cytological diagnosis, using the same molecular identification system as ours. Delgado et al [17] determined a prevalence of 94.3% for HR HPV types in Spanish women with a previous diagnosis of ASC-US. The reported HPV prevalences were similar to those found in this study.…”

Section: Discussionmentioning

confidence: 99%

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Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Vargas

J²,

Guerrero³

et al. 2016

Acta Cytologica

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Objectives: To estimate the frequency of human papillomavirus (HPV) infection and the genotype distribution of HPV among women with a Pap smear showing atypical squamous cells of undetermined significance (ASC-US) attending the Program for the Detection and Control of Cervical Cancer in Bogotá, Colombia. Study Design: Cervical samples from 200 women with an ASC-US Pap smear were analyzed for the presence of HPV DNA and genotype distribution using a commercial molecular technique (Linear Array®; Roche Molecular Systems, USA). Results: HPV infection was found in 140 women (70%). High-risk HPV types were present in 46.4% of the samples; 16.4% showed a low-risk HPV type, and 37.1% showed both. Of the positive samples, 42.9% were infected with a single viral genotype, whereas 57.1% exhibited multiple HPV infections. The most common HPV genotypes were HPV 16, 53, and 52 with a prevalence of 26.4, 16.4, and 13.6%, respectively. Conclusion: The epidemiological characterization of HPV infections described in this study might guide actions for epidemiological surveillance to strengthen the program in Bogotá and to develop appropriate HPV vaccination programs.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Vargas

J²,

Guerrero³

et al. 2016

Acta Cytologica

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“…This prevalence of multiple HPV infection is higher than found in other studies conducted in Spain in which the values range between 4.7% and 52.1% [6,29,30,34,36,38,57]. Furthermore, in a study of patients with abnormal cytology obtained a higher value (58.1%) [35] than found in this study. The variations observed could be explained by the geographical diversity of the population studied [58] and the different molecular methodologies used.…”

Section: Discussioncontrasting

confidence: 55%

“…These viral types appear to be common in the Spanish population [6,18,[35][36][37][38], and these HPV specific-genotypes were also detected in studies around the world. The proportions detected in these studies are diverse, being as high as 17.5%, 12.0%, and 8.1% respectively [35], while in other study [38] found similar rates to those of our study: 8.0%, 3.8%, and 7.1%, respectively. Very low proportions have also been detected, such as 1.6%, 1.8%, and 1.2%, respectively [6], and HPV-51 (0.75%), HPV-52 (2.25%) and HPV-66 (0.19%) [10].…”

Section: Discussionmentioning

confidence: 96%

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Méndez¹

2013

SOJ Microbiol Infect Dis

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BackgroundCervical cancer is the second most common cancer in women worldwide and the most common cause of mortality in underdeveloped and developing countries [1,2]. Persistent infection with certain oncogenic high-risk (HR) types of Human Papillomavirus (HPV) is the required factor for the development of invasive cervical cancer and precursor lesions [3][4][5][6].Overall, the prevalence and distribution of HPV infection in cervical lesions has been determined in many geographical regions of the world, this can vary depending on several factors including epidemiological differences in the populations studied and the methodology used for molecular detection and typing of HPV DNA [7]. Over 120 types of HPV have been classified as either low (LR-HPV) or high risk (HR-HPV), according to their oncogenic potential [8,9]. Within the high-risk genotypes, HPV types 16 and HPV 18 are most often associated with cancer and squamous intraepithelial lesion [5,6,10,11,12]. Nevertheless, the risk of neoplasia for other types of HPV as well as for multiple HPV infection has not yet been established.Because current strategies for the prevention of cervical cancer and their precancerous lesions are based on the HPV genotyping [13] and prophylactic vaccines [14][15][16], it seems necessary to determine the types of HPV most commonly associated with malignant cell transformation in different geographical areas in order to establish effective preventive measures according to the epidemiology of the population. This study was to know the prevalence and distribution of cervical HPV infection in women attending routine cervical cancer screening in the Valencia region (Spain). Study designLiquid-based cytology (LBC) of cervical specimens was collected during routine screening visits, between June 20, 2011 and September 9, 2011 in the Clinical Hospital of Valencia, Spain. LBC samples were processed using the Thin Prep® 5000 processor (Madrid, Spain). For HPV detection and genotyping, we used the residual cervical sample material available from the same Thin Prep Pap test vial previously used for cytological screening. DNA was extracted from the residual materials of LBC by QIAamp® DNA mini kit (IZASA, Valencia, Spain), according to the manufacturer's instructions. HPV testing was performed by INNO-Lipa HPV genotyping Extra Reverse Hybridization Line Probe Assay kit (Innogenetics®, Barcelona, Spain), according to the manufacturer's instructions. Briefly, HPV detection and genotyping was based on PCR amplification of a 65pb fragment, within the L1 region of the HPV genome, using broad-spectrum SPF10 biotinylated primers. PCR was performed in a final AbstractBackground: Infection with human papillomavirus (HPV) has been identified as the primary cause of cervical cancer. Persistent infection with high risk-HPV is the required factor for the development of cervical cancer.

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Correlation of cervical cytology with high‐risk HPV molecular diagnosis, genotypes, and histopathology—A four year study from the UAE

Krishnan

Thomas

2015

Diagnostic Cytopathology

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Assessment of cervical cytology reporting pattern, correlation of cervical cytology with HPV molecular diagnosis, and biopsy histopathology is a useful way to audit our work and a good quality control practice. Higher prevalence of HPV HR types such as type 51, 31 as well as 66, 56, and 59 found in the present as well as many similar other studies apart from the commonest subtype 16 may imply necessity for development of more targeted and multivalent anti-HPV vaccines for protection of women in our region. HPV genotypes correlation with the nationalities of patients is useful from an epidemiological standpoint to plan preventive strategies.

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Human papillomavirus (HPV) genotype distribution in women with abnormal cervical cytology in the Basque Country, Spain

Cited by 15 publications

References 34 publications

Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Prevalence of Human Papillomavirus (HPV) Genotypes and Multiple Infections in Routine Cervical Cancer Screening in a Spanish Regional Population

Correlation of cervical cytology with high‐risk HPV molecular diagnosis, genotypes, and histopathology—A four year study from the UAE

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