Correlation of cervical cytology with high‐risk <scp>HPV</scp> molecular diagnosis, genotypes, and histopathology—A four year study from the <scp>UAE</scp>

Krishnan, Kavita; Thomas, Antony

doi:10.1002/dc.23391

Cited by 11 publications

(14 citation statements)

References 39 publications

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“…In addition, a subsequent meta‐analysis of women with normal cytological findings found that the adjusted HPV prevalence was 11.7%, although it varies geographically . Furthermore, previous studies in some GCC countries reported HPV prevalence ranging from 2.36% to 60.7% among women with normal cytology, whereas, among women with abnormal cytology, the HPV positivity rate ranged from 16.7% to 64.6% . The high prevalence of HR‐HPV among women with normal cytology in our study could be explained by the low sensitivity of the Papanicolaou test.…”

Section: Discussioncontrasting

confidence: 42%

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Cervical high‐risk human papillomavirus infection among women residing in the Gulf Cooperation Council countries: Prevalence, type‐specific distribution, and correlation with cervical cytology

Ali

Bedair

Atti

2019

Cancer Cytopathology

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BACKGROUND:The scarcity of updated data on the prevalence of cervical human papillomavirus (HPV) infection in the Gulf Cooperation Council (GCC) countries hampers the establishment of cervical cancer screening and HPV vaccination programs. The current study estimated the prevalence of cervical high-risk (HR) HPV infection among women residing in some countries of the GCC and analyzed the correlation between HR-HPV infection types and cytology results. METHODS:In total, 2478 women residing in the Kingdom of Saudi Arabia, Qatar, the United Arab Emirates, and Bahrain were enrolled in this study. Cervical specimens were subjected to simultaneous liquid-based cytology and HR-HPV DNA analysis. RESULTS: Of 2478 women, 520 (21%) tested positive for HR-HPV. Other non-HPV genotype 16 (HPV16)/HPV18 HR-HPV was the most frequently detected infection type, accounting for 63.7%. Non-Arab women had a significantly higher HR-HPV positivity rate compared with Arab women (31.6% vs 16.4%; P < .001). The HR-HPV positivity rate was highest among women residing in Qatar (31.3%), followed by women living in Bahrain (20%), the Kingdom of Saudi Arabia (17.2%), and the United Arab Emirates (14.7%). The overall prevalence of HR-HPV infections declined significantly with advancing age (P < .001). Women with abnormal cytology had a significantly higher HR-HPV positivity rate than those with normal cytology (50.6% vs 14.7%; P < .001). The HR-HPV positivity rate increased as the severity of the cytological lesion increased. CONCLUSIONS: The current study provides updated data on HR-HPV prevalence in the GCC countries and delivers an evidence base for supporting the introduction of regional/national vaccination and screening programs in these countries.

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Section: Discussioncontrasting

confidence: 42%

“…Conversely, the frequency of HPV16 and HPV18 double infections was 1%. In the GCC countries, although the majority of investigations found that HPV16 was the most commonly identified HR‐HPV genotype, other studies reported other non‐HPV16 HR‐HPV as the most frequently detected genotype …”

Section: Discussionmentioning

confidence: 98%

Cervical high‐risk human papillomavirus infection among women residing in the Gulf Cooperation Council countries: Prevalence, type‐specific distribution, and correlation with cervical cytology

Ali

Bedair

Atti

2019

Cancer Cytopathology

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“…Since the HPV vaccine distributed in the national program is a quadrivalent that offers protection against these two high-risk types, knowing this information can help towards developing and adopting more comprehensive vaccines in our country [37]. The frequency of this genotype distribution is quite similar to that found in another Cobas PCR study for ASC-US [38].…”

Section: Discussionsupporting

confidence: 58%

“…Another interesting finding of this study is a higher prevalence of other HR-HPV genotypes compared to HPV-16 and -18 genotypes, which are the most frequent HR-HPVs detected in other studies and more linked to squamous cell cancer [36, 37]. Since the HPV vaccine distributed in the national program is a quadrivalent that offers protection against these two high-risk types, knowing this information can help towards developing and adopting more comprehensive vaccines in our country [37].…”

Section: Discussionmentioning

confidence: 67%

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Oliveira

Eleutério

et al. 2018

Acta Cytologica

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Objective: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women. Study Design: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. Results: Enlarged nucleus was the most frequent ASC-US criterion, but alternative criteria were present in 20% of the total cases. No ASC-US criteria were associated with histological outcomes or HR-HPV positivity. Parakeratosis, corneal pearl, giant cells, and binucleation were strongly associated with ASC-US while hyperkeratosis was associated with high-grade squamous intraepithelial lesions (HSIL) or a superior outcome. HR-HPV was positive in 64.39% of ASC-US and 65.38% of ASC-H. HSIL or superior outcomes also occurred in 13.33% of ASC-US and 64.71% of ASC-H cases. Conclusion: Alternative criteria for ASC-US were relatively frequent. Reactive cellular changes suggestive of atypias were more abundant in ASC-US. Although ASC-H is associated with worse histological outcomes, no differences in HPV positivity were found in comparison to ASC-US.

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“…The findings are in keeping with the current report showing hrHPV 18 as a less frequent hrHPV type in the UAE population [ 28 ]. Similarly, Krishnan and Thomas reported HPV 16 to be the most common HPV type in cases with abnormal Pap smear [ 29 ]. Likewise, hrHPV 18 was not the second most frequent type.…”

Section: Discussionmentioning

confidence: 99%

Frequency of rare and multi viral high-risk HPV types infection in cervical high grade squamous intraepithelial lesions in a non-native dominant middle eastern country: a polymerase chain reaction-based pilot study

et al. 2018

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BackgroundThe incidence of abnormal cervical smears in the United Arab Emirates (UAE) is 3.6%. Data regarding specific high-risk HPV (hrHPV) genotypes are insufficient. Identification of hrHPV subtypes is essential to allow formulating effective vaccination strategies.MethodsA total of 75 archival cervical cone biopsies with HSIL or higher lesions (2012–2016) were retrieved from a tertiary hospital, including HSIL (n = 70), adenocarcinoma in-situ (n = 1) and squamous cell carcinoma (n = 4). Five tissue sections (10-μ-thick each) were cut and DNA extracted using the QIAamp DNA FFPE Tissue Kit. GenomeMeTM’s GeneNavTM HPV One qPCR Kit was used for specific detection of HPV 16 and 18; and non-16/18 samples were typed by GenomeMeTM’s GeneNavTM HPV Genotyping qPCR Kit.ResultsMedian age was 34 years (range 19–58) with 70% UAE Nationals. hrHPV detected were 16, 18, 31, 33, 35, 39, 45, 51, 52, 58, 59, 66 & 68. hrHPV testing was negative in 12% of cases. Most common types were HPV 16 (49%), HPV 31 (20%) and HPV 18 (6.6%). hrHPV 16 and/or 18 represented 56% and rare subtypes 32%. Co-infection was present in 16%. Eight cases had two-viral subtype infections and 4 cases had 3 subtype infections. Multi-viral HPV infection was limited to hrHPV 16, 18, 31 & 33 subtypes.ConclusionsInfection by non HPV 16/18 is fairly common. A higher than expected incidence of rare subtype (20% hrHPV31) and multi-viral hrHPV (16%) were detected. This finding stresses the importance of this pilot study as currently only quadravalent vaccine is offered to control the HPV infection in the UAE population.

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Correlation of cervical cytology with high‐risk HPV molecular diagnosis, genotypes, and histopathology—A four year study from the UAE

Cited by 11 publications

References 39 publications

Cervical high‐risk human papillomavirus infection among women residing in the Gulf Cooperation Council countries: Prevalence, type‐specific distribution, and correlation with cervical cytology

Cervical high‐risk human papillomavirus infection among women residing in the Gulf Cooperation Council countries: Prevalence, type‐specific distribution, and correlation with cervical cytology

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Frequency of rare and multi viral high-risk HPV types infection in cervical high grade squamous intraepithelial lesions in a non-native dominant middle eastern country: a polymerase chain reaction-based pilot study

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