Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells

Zheng, Sulin; Zhang, Han-Rong; Zhang, Zhenfei; Lai, Shu-Yu; Huang, Lijun; Liu, Jie; Bai, Xin; Ding, Ke; Zhou, Jue-Yu

doi:10.7150/jca.24253

Cited by 30 publications

(34 citation statements)

References 29 publications

(30 reference statements)

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“…High-risk subtypes (16 and 18) of human papillomavirus (HPV) are well established as the causative agents responsible for CC [ 69 ]. Massive studies have shown that a large number of circRNAs were differentially expressed in CC tissues compared with adjacent normal cervical tissues, and play oncogenic or tumor-suppressive roles in the initiation and progression of CC [ 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 ]. All of the circRNAs that are abnormally expressed in CC are summarized in Table 1 , and their functions in CC are shown in Figure 3 .…”

Section: The Expression Functions and Mechanisms Of Circrnas In Gmentioning

confidence: 99%

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Dong

Xiong

et al. 2020

Cancers

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Circular RNAs (circRNAs) are covalently closed, endogenous non-coding RNAs and certain circRNAs are linked to human tumors. Owing to their circular form, circRNAs are protected from degradation by exonucleases, and therefore, they are more stable than linear RNAs. Many circRNAs have been shown to sponge microRNAs, interact with RNA-binding proteins, regulate gene transcription, and be translated into proteins. Mounting evidence suggests that circRNAs are dysregulated in cancer tissues and can mediate various signaling pathways, thus affecting tumorigenesis, metastasis, and remodeling of the tumor microenvironment. First, we review the characteristics, biogenesis, and biological functions of circRNAs, and describe various mechanistic models of circRNAs. Then, we provide a systematic overview of the functional roles of circRNAs in gynecological cancers. Finally, we describe the potential future applications of circRNAs as biomarkers for prognostic stratification and as therapeutic targets in gynecological cancers. Although the function of most circRNAs remains elusive, some individual circRNAs have biologically relevant functions in cervical cancer, ovarian cancer, and endometrial cancer. Certain circRNAs have the potential to serve as biomarkers and therapeutic targets in gynecological cancers.

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Section: The Expression Functions and Mechanisms Of Circrnas In Gmentioning

confidence: 99%

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Dong

Xiong

et al. 2020

Cancers

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“…MRNA levels of P-gp and GSTP were obviously repressed after downregulation of circ-PVT1 in paclitaxel-resistant gastric cancer cells 157 . Moreover, high-throughout microarray-based circRNA profiling revealed that 526 circRNAs were dysregulated in cervical cancer cells, and bioinformatic analyses indicated that these circRNAs participated mainly in GSH metabolism 158 . However, associated miRNAs and downstream factors were not screened.…”

Section: Introductionmentioning

confidence: 99%

Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression

Zhang

Wang

et al. 2020

Cell Death Dis

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Cancer progression including proliferation, metastasis, and chemoresistance has become a serious hindrance to cancer therapy. This phenomenon mainly derives from the innate insensitive or acquired resistance of cancer cells to apoptosis. Ferroptosis is a newly discovered mechanism of programmed cell death characterized by peroxidation of the lipid membrane induced by reactive oxygen species. Ferroptosis has been confirmed to eliminate cancer cells in an apoptosis-independent manner, however, the specific regulatory mechanism of ferroptosis is still unknown. The use of ferroptosis for overcoming cancer progression is limited. Noncoding RNAs have been found to play an important roles in cancer. They regulate gene expression to affect biological processes of cancer cells such as proliferation, cell cycle, and cell death. Thus far, the functions of ncRNAs in ferroptosis of cancer cells have been examined, and the specific mechanisms by which noncoding RNAs regulate ferroptosis have been partially discovered. However, there is no summary of ferroptosis associated noncoding RNAs and their functions in different cancer types. In this review, we discuss the roles of ferroptosis-associated noncoding RNAs in detail. Moreover, future work regarding the interaction between noncoding RNAs and ferroptosis is proposed, the possible obstacles are predicted and associated solutions are put forward. This review will deepen our understanding of the relationship between noncoding RNAs and ferroptosis, and provide new insights in targeting noncoding RNAs in ferroptosis associated therapeutic strategies.

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“…2 Some studies have shown the ectopic expression of noncoding RNAs such as circRNAs and miRNAs in CC. Recent studies have revealed the ectopically expressed circRNA profiles associated with HPV 16 infection 26 and radioresistance. 27 CircRNAs with dysregulated expression are found to be associated with CC carcinogenesis and progression through the regulation of cell migration, invasion, metastasis and recurrence in CC.…”

Section: Discussionmentioning

confidence: 99%

<p>The Regulatory Role of circRNA_101308 in Cervical Cancer and the Prediction of Its Mechanism</p>

Jiao

Liu

et al. 2020

CMAR

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Purpose: Accumulating evidence indicates that circular RNAs (circRNAs) are closely involved in canceration and cancer progression. However, the role of circRNAs in cervical cancer (CC) is largely unknown. Here, we characterized the role of circRNA_101308 in CC. Materials and Methods: The expression of circRNA_101308 in CC tissues was measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Then, circRNA_101308 was overexpressed in CC cells to detect its function by proliferation and apoptosis assays, Transwell assays and animal experiments. The potential mechanism of circRNA_101308 in CC was explored by RNA pull-down, Gene Ontology (GO) and pathway analyses. Results: CircRNA_101308 was significantly downregulated in CC tissues. The level of circRNA_101308 was much lower in CC patients with lymph node metastasis or deep myometrial invasion compared to those patients without lymph node metastasis and superficial myometrial invasion. CircRNA_101308 overexpression inhibited CC cell proliferation, invasion and migration. MiR-26a-5p, miR-196a-5p, miR-196b-5p, miR-335-3p, and miR-1307-3p were found to be sponged by circRNA_101308 in CC cells. Further, GO and pathway analyses predicted the potential functional processes and pathways of circRNA_101308 in CC. Conclusion: CircRNA_101308 is downregulated and acts as a tumor suppressor in CC. CircRNA_101308 can participate in many different processes by sponging different miRNAs in CC cells. This exploration of circRNA_101308 provides new directions for research on cancer development and the clinical treatment of CC.

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Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells

Cited by 30 publications

References 29 publications

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression

<p>The Regulatory Role of circRNA_101308 in Cervical Cancer and the Prediction of Its Mechanism</p>

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