Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy

Liu, Bin; Cao, Wenwu; Cheng, Jin; Fan, Sisi; Pan, Shaojun; Niu, Jiaqi; Pan, Yun‐Xiang; Liu, Yanlei; Sun, Xuejian; Ma, Lijun; Song, Jie; Ni, Jian; Cui, Daxiang

doi:10.20892/j.issn.2095-3941.2019.0112

Cited by 35 publications

(16 citation statements)

References 49 publications

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“…Smokers have increased plasma concentrations of various toxic heavy metals, which are responsible for the genotoxic effects of cigarettes on human DNAs by inducing double‐strand breakage and inhibiting DNA repair 39 . The protective effect of GNPs can be explained by the interaction between cellular constituents and GNPs; when reduced by citrate, GNPs actively interact with leukocytes, erythrocytes, and platelets to increase adsorption 40,41 . This beneficial interaction between GNPs and defense cells, called hemocompatibility, forms a corona enriched with proteins involved in humoral immunity and increases the ability of defense cells to fight pathological agents and repair damaged cells 40 .…”

Section: Discussionmentioning

confidence: 99%

“…39 The protective effect of GNPs can be explained by the interaction between cellular constituents and GNPs; when reduced by citrate, GNPs actively interact with leukocytes, erythrocytes, and platelets to increase adsorption. 40,41 This beneficial interaction between GNPs and defense cells, called hemocompatibility, forms a corona enriched with proteins involved in humoral immunity and increases the ability of defense cells to fight pathological agents and repair damaged cells. 40 Another finding of this study was that GNPs did not exacerbate DNA damage, as there was no increase in the indices and frequencies of DNA damage in mice exposed to CS and treated with GNPs compared to those in the CS group.…”

Section: Discussionmentioning

confidence: 99%

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Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke

et al. 2021

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Inhalation of harmful particles appears as a primary factor for the onset and establishment of chronic obstructive pulmonary disease (COPD). Cigarette smoke acutely promotes an exacerbated inflammatory response with oxidative stress induction with DNA damage. Administration of Gold Nanoparticles (GNPs) with 20 nm in different concentrations can revert damages caused by external aggravations. The effects of GNPs in a COPD process have not been observed until now. The objective of this work was to evaluate the therapeutic effects of intranasal administration of different doses of GNPs after acute exposure to industrial cigarette smoke. Thirty male Swiss mice were randomly divided into five groups: Sham; cigarette smoke (CS); CS + GNPs 2.5 mg/L; CS + GNPs 7.5 mg/L and CS + GNPs 22.5 mg/L. The animals were exposed to the commercial cigarette with filter in an acrylic inhalation chamber and treated with intranasal GNPs for five consecutive days. The results demonstrate that exposure to CS causes an increase in inflammatory cytokines, histological changes, oxidative and nitrosive damage in the lung, as well as increased damage to the DNA of liver cells, blood plasma and lung. Among the three doses of GNPs (2.5, 7.5, and 22.5 mg/L) used, the highest dose had better anti‐inflammatory effects. However, GNPs at a dose of 7.5 mg/L showed better efficacies in reducing ROS formation, alveolar diameter, and the number of inflammatory cells in histology, in addition to significantly reduced rate of DNA damage in lung cells without additional systemic genotoxicity already caused by cigarette smoke.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke

et al. 2021

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“…Based on the traditional seed method, further integration and chemical modification of AuNSs with other components leads to the creation of various kinds of AuNSbased nanohybrids, such as metal compound/AuNSs, 28 SiO 2 /AuNSs, 30 dendrimer/AuNSs, 20 and MOF/AuNSs nanohybrids. 22 For instance, Montoto et al 30 reported the preparation of mesoporous silica-coated AuNSs.…”

Section: Single Seed-mediated Growth Methodsmentioning

confidence: 99%

Gold nanostar‐based complexes applied for cancer theranostics

Yang

Gao

Ouyang

et al. 2022

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Cancer remains a major health problem that plagues human beings, calling widespread attention to develop novel theranostics to achieve sensitive diagnosis and efficient therapy. Multifunctional nanomedicine that can integrate diagnosis with treatment formulations has been emerging as a powerful strategy to overcome the current drawbacks in conventional clinical cancer treatments. Due to the good biocompatibility, easy surface modification, surface-enhanced Raman spectroscopy (SERS)/computed tomography (CT)/photoacoustic (PA) imaging properties, and exceptional photothermal performance of gold nanostars (AuNSs), various AuNS-based complexes or nanohybrids including metal compound/AuNSs, SiO 2 /AuNSs, polymer/AuNSs, and dendrimer/AuNSs, and so forth have been developed, holding great blueprint in cancer theranostics.Herein, we concisely review the recent progresses in the intriguing design of AuNS-based nanoplatforms, and their applications in bioimaging, therapy and imaging-guided cancer treatment, and clarify the possible future perspectives for the design of AuNS-facilitated cancer theranostics.

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“…NK cells expansion in genetically engineered K562 cells was performed from umbilical cord blood mononuclear cells (UB-MNCs). Irradiated K562 feeder cells were received from Hangzhou Zhongying Bio-Medical Technology (Zhejiang, China), which coexpress membrane-bound IL-21 and CD137L (4-1BBL) 23 . On day 0, UB-MNCs and 2 × 10 7 genetically engineered K562 cells (K562-mb215-41BBL, Zhongying Bio-Medical Technology) were resuspended in 40 ml NK cell medium [containing 90% RPMI-1640 HyClone, Logan, UT, USA; 10% fetal bovine serum, Gibco, Carlsbad, CA, USA; and 100 µg/ml IL-2, R&D, Minneapolis, MN, USA].…”

Section: Methodsmentioning

confidence: 99%

Cord Blood Natural Killer Cells Inhibit Sepsis Caused by Feces-Induced Acute Peritonitis via Increasing Endothelium Integrity

et al. 2022

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Sepsis is associated with acute peritonitis, which can be induced by lipopolysaccharide exposure and feces. Generally, lipopolysaccharide induces mono-microbial peritonitis, whereas feces cause poly-microbial peritonitis; the latter is a more complicated and closer to the clinical diseases. Although several reports have discussed the mechanism of immune response in peritonitis-induced sepsis, however, the role of natural killer (NK) cells in sepsis, especially the relationship between NK cells and stabilization of the vascular endothelial barrier, is still unclear. Accordingly, in this study, we assessed the roles of NK cells in an acute sepsis model in mice. NK cells were injected via the tail vein into mice with acute sepsis, and nitric oxide (NO), anti-inflammatory cytokine, and angiogenic factors were tested to explore the effects of NK cells on sepsis. The survival rate of septic model mice infused with NK cells was significantly improved compared with the control group. Interestingly, the levels of NO, interleukin-10, and vascular endothelial growth factor (VEGF) decreased in NK cells therapy group. After the injection of NK cells, CD31 positive endothelial cells significantly increased in the kidneys and liver, although the expression of VEGF, ANGPT-1, and ET-1 was downregulated. Consistent with our hypothesis, the transfusion of NK cells into mice with sepsis blocked inflammation and increased endothelium integrity. Overall, these findings suggest that NK cells may block sepsis by modulating the VEGF pathway.

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Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy

Cited by 35 publications

References 49 publications

Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke

Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke

Gold nanostar‐based complexes applied for cancer theranostics

Cord Blood Natural Killer Cells Inhibit Sepsis Caused by Feces-Induced Acute Peritonitis via Increasing Endothelium Integrity

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