Human nail dust and precipitating antibodies to Trichophyton rubrum in chiropodists

Davies, R. R.; Ganderton, M. A.; Savage, M

doi:10.1111/j.1365-2222.1983.tb02605.x

Cited by 24 publications

(12 citation statements)

References 4 publications

(2 reference statements)

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“…180 Occupational exposure to airborne Trichophyton in nail dust has been shown to induce nasal and eye symptoms in chiropodists. 181 Sensitization to Trichophyton is also reported to be a risk factor for more severe disease among the general asthmatic population. 182 Some allergenic proteins from fungi of the genus Trichophyton have been identified and approved by the WHO/IUIS Allergen Nomenclature Sub-committee.…”

Section: Candidamentioning

confidence: 98%

Sensitization to fungal allergens: Resolved and unresolved issues

Fukutomi

Taniguchi

2015

Allergology International

176

136

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Exposure and sensitization to fungal allergens can promote the development and worsening of allergic diseases. Although numerous species of fungi have been associated with allergic diseases in the literature, the significance of fungi from the genera Alternaria, Cladosporium, Penicillium, Aspergillus, and Malassezia has been well documented. However, it should be emphasized that the contribution of different fungal allergens to allergic diseases is not identical, but species-specific. Alternaria and Cladosporium species are considered to be important outdoor allergens, and sensitization and exposure to species of these genera is related to the development of asthma and rhinitis, as well as epidemics of asthma exacerbation, including life-threatening asthma exacerbation. In contrast, xerophilic species of Penicillium and Aspergillus, excluding Aspergillus fumigatus, are implicated in allergic diseases as indoor allergens. A. fumigatus has a high capacity to colonize the bronchial tract of asthmatic patients, causing severe persistent asthma and low lung function, and sometimes leading to allergic bronchopulmonary aspergillosis. Malassezia are common commensals of healthy skin, although they are also associated with atopic dermatitis, especially on the head and neck, but not with respiratory allergies. Despite its importance in the management of allergic diseases, precise recognition of species-specific IgE sensitization to fungal allergens is often challenging because the majority of fungal extracts exhibit broad cross-reactivity with taxonomically unrelated fungi. Recent progress in gene technology has contributed to the identification of specific and cross-reactive allergen components from different fungal sources. However, data demonstrating the clinical relevance of IgE reactivity to these allergen components are still insufficient.

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Section: Candidamentioning

confidence: 98%

Sensitization to fungal allergens: Resolved and unresolved issues

Fukutomi

Taniguchi

2015

Allergology International

176

136

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“…The possibility of transmission, by aerosolisation, of blood and body fluids of hepatitis B or HIV, 15 or through the conjunctiva 16 17 exists. The smaller airborne particulates create an aerosol with distribution throughout the respiratory system [18][19][20][21] and damage to immunocompromised clients. 22…”

Section: Microorganisms Encounteredmentioning

confidence: 99%

World at work: Evidence based risk management of nail dust in chiropodists and podiatrists

Burrow

McLarnon²

2006

Occup Environ Med

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“…However, there is no data to subscribe to this view. Human nail dust, partly mimicking dust, has been reported to cause different respiratory and nonrespiratory illnesses (Abramson and Wilton 1985;Davies and Ganderton 1975;McLarnon et al 2005, Duell et al 1991Health and Safety Executive Publications 1991;Millar 2000;Davies et al 1983;Ward 1995).…”

Section: Discussionmentioning

confidence: 96%

Industrial hygiene and toxicity studies in unorganized bone-based industrial units

Siddiqui

Ashquin

Prasad

et al. 2010

Environ Monit Assess

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A large variety of ornamental and decorative items are manufactured from bone waste by various unorganized sectors in India. An initial survey indicated that workers were exposed at various phases of final product. The subjects (12 industrial units) were tested for total suspended particulate matter (TSPM), particulate matter <10 microm (PM(10)), and particulate matter <2.5 microm (PM(2.5)). Prevalent levels of TSPM ranged between 2.90 and 5.89 mg m(-3). Respirable fractions of occupational dust as PM(10) and PM(2.5) were found in the range of 0.30-2.08 and 0.26-0.50 mg m(-3), respectively. Cytotoxicity study was conducted using hemolysis as a sensitive marker. In an in vitro study, rat RBCs were exposed to the concentration of 25-1,000 microg/ml for 15-120 min. A considerable variation was observed in the hemolytic activity of samples collected from different areas. At 500 microg/ml concentration, the hemolytic activity (12 h) was found to be in the range of 18-25%. Due to limitation in sample mass of respirable fractions, only one concentration (100 microg/ml/2 h) was used for comparative study on hemolysis of RBCs caused by PM(10) and PM(2.5). Interestingly, the hemolytic activity was more at PM(2.5) than PM(10) and TSPM. These results suggest that the respirable particles are capable of reaching deep into the respiratory system. The finding is significant notably when there are no standards available in occupationally exposed populations. This is the first such study. Data could be of importance to policy makers and regulators.

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Human nail dust and precipitating antibodies to Trichophyton rubrum in chiropodists

Cited by 24 publications

References 4 publications

Sensitization to fungal allergens: Resolved and unresolved issues

Sensitization to fungal allergens: Resolved and unresolved issues

World at work: Evidence based risk management of nail dust in chiropodists and podiatrists

Industrial hygiene and toxicity studies in unorganized bone-based industrial units

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