Human mast cells express leptin and leptin receptors

Taildeman, Jasmien; Pérez-Novo, Claudina; Rottiers, Isabelle; Ferdinande, Liesbeth; Waeytens, Anouk; Colvenaer, Veerle De; Bachert, Claus; Demetter, Pieter; Waelput, Wim; Braet, Katleen; Cuvelier, Claude

doi:10.1007/s00418-009-0575-3

Cited by 47 publications

(42 citation statements)

References 26 publications

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“…It is tempting to speculate that the accumulation of mast cells in adipose tissue in pathological conditions may also contribute to the secretory potential of adipose tissue, and emphasizes the inflammatory process observed at the onset of obesity. In addition, human mast cells granules contain leptin [34], an adipokine known to inhibit fat accumulation. Activation and degranulation of mast cells may enhance proliferation of mesenchymal cells [35], leading to an amplification of adipose tissue growth.…”

Section: Discussionmentioning

confidence: 99%

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

et al. 2010

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White adipose tissue (WAT) is a heterogeneous tissue, found in various locations throughout the body, containing mature adipocytes and the stroma‐vascular fraction (SVF). The SVF includes a large proportion of immune hematopoietic cells, among which, mast cells that contribute to diet‐induced obesity. In this study, we asked whether mast cells present in mice adipose tissue could derive from hematopoietic stem/progenitor cells (HSPC) identified in the tissue. We therefore performed both in vitro and in vivo experiments dedicated to monitoring the progeny of WAT‐derived HSPC. The entire study was conducted in parallel with bone marrow‐derived cells, considered the gold standard for hematopoietic‐lineage studies. Here, we demonstrate that adipose‐derived HSPC contain a precursor‐cell population committed to the mast cell lineage, and able to efficiently home to peripheral organs such as intestine and skin, where it acquires properties of functional tissue mast cells. Additionally, WAT contains a significant mast cell progenitor population, suggesting that the entire mast cell lineage process take place in WAT. Considering the quantitative importance of WAT in the adult organism and the increasing roles recently assigned to mast cells in physiopathology, WAT may represent an important source of mast cells in physiological and pathological situations. STEM CELLS 2010;28:2065–2072

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Section: Discussionmentioning

confidence: 99%

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

et al. 2010

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“…Adipokines have been linked to the pathogenesis of MS and its comorbidities through their effects on vascular function and inflammation. Human mast cells may be also a direct target of adipokine activity (27,28). Systemic inflammation generated during obesity is characterized by an oversecretion of inflammatory markers such as CRP, IL-6, IL-1beta, TNF-alpha, leptin and visfatin, with a simultaneous hyposecretion of anti-inflammatory and anti-atherogenic substances (12,15,29).…”

Section: Metabolic Syndromementioning

confidence: 99%

The link between chronic spontaneous urticaria and metabolic syndrome

Veña¹,

Cassano²

2017

Eur Ann Allergy Clin Immunol

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Summary Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and is considered a chronic low-level systemic inflammatory condition. Recent preliminary findings have shown an increased prevalence of MS among patients with chronic urticaria (CU) as compared to controls, with a particularly higher prevalence detected in patients with uncontrolled CU. Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with MS, including a pro-inflammatory state, increased oxidative stress, alterations in adipokine profile

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“…Mast cells are immune cells secreting many mediators and cytokines that influence different inflammatory and immune processes. Taildeman et al [54] have identified the production of leptin and leptin receptors in mast cells in the various studied tissues, indicating paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.…”

Section: The Biological Activity Of Leptinmentioning

confidence: 99%

Emerging role of leptin in rheumatoid arthritis

Tian

Liang

Wang

et al. 2014

Clinical and Experimental Immunology

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SummaryNumerous studies have suggested the importance of leptin against autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS) and psoriasis. To summarize our current understanding of the role of leptin in inflammatory responses and rheumatoid arthritis (RA), a systematic review was conducted to assess the discrepancy of leptin in RA and its effect on immunity according to different studies. Recently, emerging data have indicated that leptin is involved in the pathological function of RA, which is common in autoimmune disorders. This review discusses the possible consequences of leptin levels in RA. Blocking the key signal pathways of leptin and inhibiting the leptin activity-like leptin antagonist may be a promising way for potential therapeutic treatment of RA at risk of detrimental effects. However, leptin was increased in patients with RA and may also regulate joint damage. Thus, more understanding of the mechanism of leptin in RA would be advantageous in the future.

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Human mast cells express leptin and leptin receptors

Cited by 47 publications

References 26 publications

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

The link between chronic spontaneous urticaria and metabolic syndrome

Emerging role of leptin in rheumatoid arthritis

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