Emerging role of leptin in rheumatoid arthritis

Tian, Guo; Liang, Jianing; Wang, Z.-Y.; Zhou, Dian

doi:10.1111/cei.12372

Cited by 62 publications

(87 citation statements)

References 138 publications

(185 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tian et al (2014) [26] reported a review in which 23 studies were analyzed. The following results were obtained: 13 studies showed increased leptin levels; 8 studies did not demonstrate any significant difference and 2 had reduced leptin levels when compared to control subjects.…”

Section: Leptinmentioning

confidence: 99%

Adipokines in rheumatoid arthritis

et al. 2018

View full text Add to dashboard Cite

Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability. In recent years the role of adipokines in the pathogenesis of rheumatoid arthritis has been discussed but results are still conflicting. Although results from some studies have shown the implications of adipokines in the pathophysiology of autoimmune diseases, including rheumatoid arthritis, their role in the pathogenesis of disease progression is not clear. Thus, this review aimed to describe the association of key adipokines (leptin, resistin, visfatin and adiponectin) and rheumatoid arthritis, given the high prevalence of this disease and the important social impact caused by this chronic disabling disease.

show abstract

Section: Leptinmentioning

confidence: 99%

Adipokines in rheumatoid arthritis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Consequently, comorbidities and metabolic alterations associated with HS include overweight, obesity, diabetes, insulin resistance, glucose intolerance, hyperlipidemia [64,65,66,68,69,70], as well as dysregulated adipokine levels [32,71], which may all be possible modulators of disease activity (e.g., obesity is related to increased levels of proinflammatory circulating cytokines TNF-α and IL-1β secreted by visceral fat macrophages [13,72]; insulin resistance, which is strongly linked to obesity, is aggravated by TNF-α-IKKβ-mediated inhibitory phosphorylation of insulin receptor substrate-1 [73], etc.). Therefore, clinicians should take into account that HS patients may have 1 or more undiagnosed components of the metabolic syndrome despite their young age, thus requiring appropriate targeted screening.…”

Section: Comorbiditiesmentioning

confidence: 99%

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Scuderi

Monfrecola

Dessy

et al. 2017

Skin Appendage Disord

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with painful nodules, abscesses, sinus tracts, and scarring primarily affecting apocrine gland-rich intertriginous areas. HS prevalence ranges from 0.05 to 1%. The central pathogenic event in HS is believed to be the occlusion of the upper part of the folliculopilosebaceous unit, leading to the rupture of the sebofollicular canal with the consequent development of perifollicular lymphohistiocytic inflammation. The HS treatment choices are influenced by disease severity and its individual subjective impact, involving both medical and surgical interventions. However, given the chronic nature of HS, its destructive impact on social, working, and daily life of patients, its management is often frustrating for both the patient and physician. Hence, prompt and effective management strategies are urgently needed and a multidisciplinary approach is advocated. Therefore, in this article, we highlighted the main features of HS (clinical aspects, epidemiology, pathogenesis, diagnostic criteria, classifications, comorbidities, and treatments), so that awareness of this disease might be heightened in primary care physicians and surgeons, who may be the first health care providers to see patients with this disease owing to its characteristic clinical presentation (inflammatory nodules, abscesses, sinus tract, etc.).

show abstract

“…In mice, a single mutation in the ob gene (an equivalent of the Lep gene in humans) leads to obesity. The same phenotype is observed in mice lacking the leptin receptor (db/db genotype) (6,10). Circulating leptin levels correlate with the amount of fat and body mass index (BMI).…”

Section: The Biological Activities Of Leptinmentioning

confidence: 73%

“…Its most evident function is the control of appetite and energy balance. A considerable interest in this adipokine has emerged these past fifteen years, especially in autoimmune diseases (4,6). Changes in body composition are described in autoimmune diseases such as rheumatoid arthritis (RA) and obesity is currently viewed as a predisposing factor for the development of some of these diseases, including psoriasis and RA (7).…”

Section: Introductionmentioning

confidence: 99%