Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Scuderi, Nicolò; Monfrecola, Ambra; Dessy, Luca Andrea; Fabbrocini, Gabriella; Megna, Matteo; Monfrecola, Giuseppe

doi:10.1159/000462979

Cited by 65 publications

(85 citation statements)

References 153 publications

(189 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it may not capture the widely variable clinical presentation of HS. Furthermore, it possesses limited value for monitoring the efficacy of medical and surgical interventions . Given our findings, the number of body sites may have increased utility over Hurley grading when assessing the risk of recurrence post‐excisional surgery.…”

Section: Discussionmentioning

confidence: 95%

Factors influencing the local cure rate of hidradenitis suppurativa following wide local excision

Ngaage

et al. 2019

International Wound Journal

View full text Add to dashboard Cite

Wide local excision is the gold standard and only potential curative therapy for recalcitrant hidradenitis suppurativa. However, high recurrence rates persist even post-surgery with little known on the influencing factors for remission. We evaluated the effect of patient, disease, and operative factors on local cure rate of moderate to severe hidradenitis following wide local excision. We performed a retrospective chart review for all patients who had undergone surgical excision of hidradenitis at a university hospital from 2012 to 2018. We identified 79 patients with a total of 220 operative sites. The majority were obese (mean body mass index [BMI] 32.5), female (71%), African-American (84%), and had a mean age of 31 years. A quarter of operative sites experienced a recurrence (n = 56). Patients who achieved remission had a significantly lower number of affected regions than those who experienced a recurrence (2.3 vs 3.6, P = .0023). Additionally, recurrence rate differed significantly between body locations (P = .0440). Smoking, BMI, Hurley grade, closure method, and excision size did not influence local cure rate. Surgical excision remains a worthy management option for hidradenitis patients with three quarters achieving remission after a single operation. Number of affected regions and location of hidradenitis may play a factor in recurrence.

show abstract

Section: Discussionmentioning

confidence: 95%

Factors influencing the local cure rate of hidradenitis suppurativa following wide local excision

Ngaage

et al. 2019

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…Although recent studies have shown that monoclonal antibodies against TNF- α are effective in moderate to severe HS, none of our patients had yet to receive biologic treatment [ 28 ]. This is due to our limited financial resources in this fully funded government clinic.…”

Section: Discussionmentioning

confidence: 99%

Hidradenitis Suppurativa in Kuala Lumpur, Malaysia: A 7-Year Retrospective Review

Kamil

Affandi

2018

Dermatology Research and Practice

View full text Add to dashboard Cite

Introduction Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition characterized by inflamed nodules, abscesses, sinus tracts, and scarring, which can occur in any skin containing folliculopilosebaceous units. We aim to identify the demographic and clinical characteristics and treatment modalities in patients with HS. Methods A retrospective analysis involving records of patients diagnosed with HS in Hospital Kuala Lumpur from July 2009 to June 2016. Results Sixty-two patients were identified, with equal cases involving males and females. Majority of patients were Malays (41.9%), followed by Indians (35.5%), Chinese (17.7%), and other ethnicities (4.8%). Median age at diagnosis was 25 (IQR: 14) years. There is a delay in diagnosis with a median of 24 (IQR: 52) months. Most of the patients had lesions on the axilla (85.5%), followed by groin (33.9%) and gluteal region (29%). Gluteal lesions were more common in males. Nodules (67.7%), sinuses (56.5%), and abscesses (33.9%) were the main clinical features, with 43.5% classified under Hurley stage 2. There was no difference in terms of symptoms and types of lesions among different ethnicities and genders. Majority received systemic antibiotics, more than half had retinoid, and third of the patients had surgical intervention. Conclusions A prompt recognition of HS is imperative, to screen for comorbidities and to initiate early treatment to reduce physical and psychological complications.

show abstract

“…Multiple reconstructive modalities after surgical excision have been described, including primary closure, healing by secondary intent, split-thickness skin graft (STSG), and flap closure [16]. Scuderi et al [17] recently reviewed several surgical and reconstructive techniques for HS. Despite the many surgical and reconstructive techniques available, there is still no general consensus on the preferred surgical technique [18,19] (Table 1).…”

Section: Reconstructive Techniquesmentioning

confidence: 99%

Hidradenitis Suppurativa: Surgical and Postsurgical Management

Manfredini

Garbarino

Bigi

et al. 2020

Skin Appendage Disord

View full text Add to dashboard Cite

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disorder. Several medical treatments, with varying degrees of efficacy, have been developed. However, in most cases of advanced HS, the definitive treatment option is often represented by surgical excisions. Objective: Surgical techniques, reconstructive approach, and local wound care should be accurately designed in order to obtain the best result. In this review we analyze the possible surgical treatments and local wound care. Methods: A MEDLINE search was performed on the various surgical treatments, reconstructive techniques, and local wound care. Results: Surgical treatment is a common therapeutic modality for HS. Different surgical reconstructive techniques and post-surgical wound care approaches are described for the management of HS patients. Conclusions: There were few high-quality evidence-based studies evaluating the surgical management of HS. Many disparate HS severity scores were used in these studies, making comparisons between them difficult. Nonetheless, research on different surgical approaches and wound care management has increased substantially in the past decade and it has given patients more surgical therapeutic strategies. The description of the best combinations and timing of surgery, wound care, and medical therapies will be a matter of future research for the definition of the optimal management of the HS patient.

show abstract

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Cited by 65 publications

References 153 publications

Factors influencing the local cure rate of hidradenitis suppurativa following wide local excision

Factors influencing the local cure rate of hidradenitis suppurativa following wide local excision

Hidradenitis Suppurativa in Kuala Lumpur, Malaysia: A 7-Year Retrospective Review

Hidradenitis Suppurativa: Surgical and Postsurgical Management

Contact Info

Product

Resources

About