Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

Simoni, Yannick; Fehlings, Michael G.; Kløverpris, Henrik N.; McGovern, Naomi; Koo, Si-Lin; Loh, Chiew Yee; Lim, Shawn; Kurioka, Ayako; Fergusson, Joannah R; Tang, Choong Leong; Kam, Ming Hian; Koh, David; Lim, Tony Kiat Hon; Fui, Alexander Chung Yaw; Hoong, Chan Weng; Chan, Jerry Kok Yen; Lafaille, Maria Curotto de; Narayanan, Sriram; Baig, Sonia; Shabeer, Muhammad; Toh, Sue‐Anne; Tan, Hak Koon; Anicete, Rosslyn; Tan, Eng‐Huat; Takano, Angela; Klenerman, Paul; Leslie, Alasdair; Tan, Daniel S.W.; Tan, Iain Beehuat; Ginhoux, Florent; Newell, Evan W.

doi:10.1016/j.immuni.2018.04.028

Cited by 107 publications

(196 citation statements)

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“…Using high‐dimensional analysis based on mass cytometry, we observed that ILC1 cells did not constitute a distinct or consistent population at the phenotypical or functional levels in any of the tissues tested. We showed that other cell subsets, such as T cells, contaminated the gating strategies used typically for ILC1 identification . Consistent with these observations, various other publications have reported the expression of T cell markers on ILC1 cells, including intracellular CD3, invariant TCR (iTCR)‐β, CD5, CD8 and CD4 .…”

Section: Ilc Subset Heterogeneity In Humanssupporting

confidence: 85%

“…Of note, many markers are expressed differentially among each ILC group. For instance, CD39, CD56, NKp46 or CD161 are expressed heterogeneously by human ILC3 . Similar observations have been carried out for ILC2 cells and expression of NKp30, CD49a or c‐Kit .…”

Section: Ilc Subset Heterogeneity In Humanssupporting

confidence: 79%

“…Similar observations have been made for ILC3. Recently, we analysed simultaneously the frequencies of all ILC subsets throughout a range of 12 different human tissues . As reported, NK cells constituted the main ILC subsets in internal tissues (blood, cord blood, bone marrow, spleen) as well as in lung.…”

Section: Ilc Subsets Are Distributed Heterogeneously Throughout Humanmentioning

confidence: 89%

“…Lymphoid tissues inducer (LTi) is required for the formation of lymph nodes through the production of lymphotoxin α/β, and is able to produce IL‐17 . Other ILC3 cells can be divided into two major subsets based on the expression of NKp44, and are referred to as NKp44 − ILC3 and NKp44 + ILC3 cells . Both subsets can produce IL‐17.…”

Section: Ilc Subset Heterogeneity In Humansmentioning

confidence: 99%

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Dissecting human ILC heterogeneity: more than just three subsets

Simoni

Newell

2017

Immunology

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SummaryInnate lymphoid cells (ILCs) have been divided into three distinct groups based on functional capacities, cytokine profiles and transcription factor expression. Studies performed mainly in mice have demonstrated the importance of ILCs in chronic inflammation, infection, allergy and cancer. In this review, we discuss the heterogeneity of human ILC and focus primarily on the taxonomy of human ILC cell subsets and their phenotypical and functional diversity. We summarize recent findings concerning the diversity of ILCs between and within the major subsets [natural killer (NK), ILC1, intra-epithelial ILC1 (ieILC1), ILC2, ILC3, lymphoid tissues inducer (LTi) and ILC progenitor (ILCP)], as well as the abundance of each in human tissues. We also discuss the similarities observed between groups of cells in term of receptors expressed and cytokines produced, and how these relate to the pleiotropic properties of each subset.

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Section: Ilc Subset Heterogeneity In Humanssupporting

confidence: 85%

Section: Ilc Subset Heterogeneity In Humanssupporting

confidence: 79%

Section: Ilc Subsets Are Distributed Heterogeneously Throughout Humanmentioning

confidence: 89%

Section: Ilc Subset Heterogeneity In Humansmentioning

confidence: 99%

See 2 more Smart Citations

Dissecting human ILC heterogeneity: more than just three subsets

Simoni

Newell

2017

Immunology

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“…However, when their functions become dysregulated, ILCs may also play roles in pathogenesis. 62,63 ILC1s 57 However, ILCs remain somewhat plastic and can alter their phenotype and function in response to signals from their surrounding tissue microenvironments.…”

Section: Innate Lymphoid Cellsmentioning

confidence: 99%

Tissue‐resident innate immunity in the lung

2019

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The lung is a unique organ that must protect against inhaled pathogens and toxins, without mounting a disproportionate response against harmless particulate matter and without compromising its vital function. Tissue-resident immune cells within the lung provide local immunity and protection from infection but are also responsible for causing disease when dysregulated. There is a growing appreciation of the importance of tissue-resident memory T cells to lung immunity, but non-recirculating, tissue-resident, innate immune cells also exist. These cells provide the first line of defence against pulmonary infection and are essential for co-ordinating the subsequent adaptive response. In this review, we discuss the main lung-resident innate immune subsets and their functions in common pulmonary diseases, such as influenza, bacterial pneumonia, asthma and inflammatory disorders.

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