Microenvironmental modulation of the developing tumour: an immune‐stromal dialogue

Jones, James O.; Moody, William M.; Shields, Jacqueline D.

doi:10.1002/1878-0261.12773

Cited by 11 publications

(5 citation statements)

References 409 publications

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“…Increasing evidence suggests that a reciprocal feedback loop between cancer-associated fibroblasts and leukocytes is essential to protect the tumor from the immune surveillance. 88 In general, cancer-associated fibroblasts directly dampen immune cell recruitment and effector functions by cytokine/chemokine/growth factor secretion and cell-cell interaction, and indirectly suppress immune cell trafficking and polarization via extracellular matrix remodeling and vascular permeability. 89 Cancer-associated fibroblasts, therefore, hijack and modify the mechanisms wound fibroblasts use during the normal woundhealing process to regulate the tumor niche.…”

Section: Immune Dysregulation By Pathological Fibroblastsmentioning

confidence: 99%

“…In analogy to wound fibroblasts, 86,87 cancer‐associated fibroblasts are key immune modulators in skin tumors. Increasing evidence suggests that a reciprocal feedback loop between cancer‐associated fibroblasts and leukocytes is essential to protect the tumor from the immune surveillance 88 . In general, cancer‐associated fibroblasts directly dampen immune cell recruitment and effector functions by cytokine/chemokine/growth factor secretion and cell‐cell interaction, and indirectly suppress immune cell trafficking and polarization via extracellular matrix remodeling and vascular permeability 89 .…”

Section: Wound Fibroblast Arise During Wound Healing and Scarringmentioning

confidence: 99%

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Fibroblasts as confederates of the immune system

Correa-Gallegos

Jiang

Rinkevich

2021

Immunological Reviews

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| 147 wileyonlinelibrary.com/journal/imr 1 | INTRODUC TI ON "Stromal" cell refers to the cellular component that form and maintain the structural parts of an organ, whereas parenchymal cells perform the specific organ function. Stromal cells, such as fibroblasts, have traditionally been considered as quiescent cells that primarily function to make extracellular matrices. Relevant in the clinic, these cells contribute to excessive connective tissue formation during injury repair, cancer, and fibrosis. However, these dedicated cells, and the niches they create, also orchestrate immunological functions by influencing the differentiation, movement, and activation of immune cells. Recent genetic lineage-tracing and single-cell RNA sequencing studies highlight the diversity of stromal cell populations in tissues and revealed how eclectic stromal cells orchestrate the diversity of immunological functions.These days, fibroblasts are no longer considered as mere structural components of organs but as dynamic participants in immune processes. We discuss four major mechanisms by which fibroblasts and immune cells interact: (a) paracrine signaling via cytokine and chemokine secretion, (b) direct priming via juxtacrine interactions, and (c) behavioral modulation through extracellular matrix remodeling. Finally, and more recently described, (d) transfer or mobilization of extracellular matrix microenvironments. In the following sections, we review the impact of these four modes of interaction between distinct fibroblast populations and immune cells during homeostasis, injury repair, scarring, and disease in the mammalian skin. Finally, we discuss the origins, of these and other stromal lineages, and their

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Section: Immune Dysregulation By Pathological Fibroblastsmentioning

confidence: 99%

Section: Wound Fibroblast Arise During Wound Healing and Scarringmentioning

confidence: 99%

Fibroblasts as confederates of the immune system

Correa-Gallegos

Jiang

Rinkevich

2021

Immunological Reviews

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“…On the one hand, the high pressure and mechanical stretching of the cell itself can directly promote cell proliferation [ 91 ]. On the other hand, the increased fluid flow in tissue leads to more consistent changes in fibroblasts and collagen fibers, resulting in increased matrix stiffness [ 92 ]. Further, the fluid exercise stimulates fibroblasts to produce TGF-β, thereby altering the activation status of fibroblasts and inducing sustained immunosuppressive activities [ 93 ].…”

Section: Mechanical Microenvironmentmentioning

confidence: 99%

Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis

Deng

Wang

Shi

et al. 2022

IJMS

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Oral potentially malignant disorders (OPMDs) are a group of diseases involving the oral mucosa and that have a risk of carcinogenesis. The microenvironment is closely related to carcinogenesis and cancer progression by regulating the immune response, cell metabolic activities, and mechanical characteristics. Meanwhile, there are extensive interactions between the microenvironments that remodel and provide favorable conditions for cancer initiation. However, the changes, exact roles, and interactions of microenvironments during the carcinogenesis of OPMDs have not been fully elucidated. Here, we present an updated landscape of the microenvironments in OPMDs, emphasizing the changes in the immune microenvironment, metabolic microenvironment, mechanical microenvironment, and neural microenvironment during carcinogenesis and their carcinogenic mechanisms. We then propose an immuno–metabolic–mechanical–neural interaction network to describe their close relationships. Lastly, we summarize the therapeutic strategies for targeting microenvironments, and provide an outlook on future research directions and clinical applications. This review depicts a vivid microenvironment landscape and sheds light on new strategies to prevent the carcinogenesis of OPMDs.

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“…Diffusion-weighted imaging (DWI) for MRI derives contrast from the differences of the motion of the water molecules within the tissue [ 11 ], and a negative correlation between SWE and apparent diffusion coefficient (ADC) has been shown for advanced rectal cancer [ 12 ]; however, the correlation has not been investigated in early stages. The molecular transformation from adenoma to adenocarcinoma includes interaction between tumor cells and stromal cells [ 13 ]. A high stromal fraction (SF) (i.e., SF ≥ 50%) is associated with tumor aggressiveness and increased tissue stiffness [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Endorectal Ultrasound Shear-Wave Elastography of Complex Rectal Adenoma and Early Rectal Cancer

et al. 2022

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Purpose: To investigate the diagnostic performance of endorectal ultrasound (ERUS), shear-wave elastography (SWE), and magnetic resonance imaging (MRI) in patients with a complex rectal adenoma or an early rectal cancer, i.e., T1 or T2 adenocarcinoma in a clinical setting, and to evaluate the association between SWE and stromal fraction (SF) and apparent diffusion coefficient (ADC) and SF. Method: This prospective study included patients undergoing ERUS and SWE for a rectal tumor subsequently confirmed by histopathology to be an adenoma or a T1 or T2 adenocarcinoma. The accuracy of the imaging methods was assessed by comparing the T category as determined by ERUS and MRI with histopathology, which served as the gold standard. SF was assessed on surgical specimens. Results: A total of 86 patients were included. Of these, 62 patients had adenomas and 24 patients had carcinomas, of which 11 were T1 tumors and 13 were T2 tumors. ERUS and MRI yielded sensitivity, specificity, and accuracy of 0.79 and 0.73, 0.95 and 0.90, and 0.86 and 0.78, respectively, for discrimination between benign and malignant lesions. The area under the receiver operating characteristics curve for SWE was 0.88, and with a cut-off value of 40 kPa the sensitivity, specificity, and accuracy were 0.79, 0.89, and 0.86, respectively. There was a positive correlation between SF and SWE with a p-value of <0.001 and a negative correlation between SF and ADC with a p-value of 0.011. Conclusion: Both ERUS and MRI classified T categories with a high accuracy; however, ERUS classified more adenomas correctly than MRI. In this small population, SWE could differentiate an adenoma from early carcinoma. SF was correlated with both SWE and ADC, as increasing SF tended to yield higher SWE and lower ADC values.

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Microenvironmental modulation of the developing tumour: an immune‐stromal dialogue

Cited by 11 publications

References 409 publications

Fibroblasts as confederates of the immune system

Fibroblasts as confederates of the immune system

Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis

Endorectal Ultrasound Shear-Wave Elastography of Complex Rectal Adenoma and Early Rectal Cancer

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