2015
DOI: 10.1371/journal.pntd.0003920
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Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

Abstract: BackgroundThe heptalaminate-covered, syncytial tegument is an important anatomical adaptation that enables schistosome parasites to maintain long-term, intravascular residence in definitive hosts. Investigation of the proteins present in this surface layer and the immune responses elicited by them during infection is crucial to our understanding of host/parasite interactions. Recent studies have revealed a number of novel tegumental surface proteins including three (SmCD59a, SmCD59b and Sm29) containing uPAR/L… Show more

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Cited by 20 publications
(46 citation statements)
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References 61 publications
(102 reference statements)
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“…On the other hand, we did observe an increase to SmLy6A. These data are in apparent contradiction to a previously published study showing that antibodies to SmLy6A decreased after treatment . Similar to the study by Chalmers et al, the effect of treatment was examined in participants with an antibody response above the cut‐off set using nonendemic European donors at baseline.…”
Section: Discussioncontrasting
confidence: 99%
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“…On the other hand, we did observe an increase to SmLy6A. These data are in apparent contradiction to a previously published study showing that antibodies to SmLy6A decreased after treatment . Similar to the study by Chalmers et al, the effect of treatment was examined in participants with an antibody response above the cut‐off set using nonendemic European donors at baseline.…”
Section: Discussioncontrasting
confidence: 99%
“…However, not all Schistosoma antigens induce an increase in antibodies following PZQ treatment. For example, IgG1 levels against rSmLy6A and rSmLy6B have been shown to drop following PZQ treatment among antibody responders . Similarly, we also found a drop in IgG1, IgG4 and IgE to rSmKK7, rSmLy6B and rSmTSP7, respectively, after PZQ treatment among antibody responders.…”
Section: Discussionsupporting
confidence: 75%
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