2020
DOI: 10.1093/infdis/jiaa329
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Screening of a Library of Recombinant Schistosoma mansoni Proteins With Sera From Murine and Human Controlled Infections Identifies Early Serological Markers

Abstract: Background Schistosomiasis is a major global health problem caused by blood-dwelling parasitic worms, which is currently tackled primarily by mass administration of the drug praziquantel. Appropriate drug treatment strategies are informed by diagnostics that establish the prevalence and intensity of infection, which, in regions of low transmission, should be highly sensitive. Methods To identify sensitive new serological mark… Show more

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Cited by 11 publications
(10 citation statements)
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References 48 publications
(48 reference statements)
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“…); (iii) using sera from experimentally infected non-endemic individuals (e.g. experimental infections in man) [51,52] or (iv) by using sera from experimentally infected animals using the original or a closely related parasite species (e.g. hookworm infections in gerbils/dogs, Schistosoma spp.…”
Section: There Is a Need For Well-characterized Biobanks For Biomarker Discoverymentioning
confidence: 99%
“…); (iii) using sera from experimentally infected non-endemic individuals (e.g. experimental infections in man) [51,52] or (iv) by using sera from experimentally infected animals using the original or a closely related parasite species (e.g. hookworm infections in gerbils/dogs, Schistosoma spp.…”
Section: There Is a Need For Well-characterized Biobanks For Biomarker Discoverymentioning
confidence: 99%
“…Crosnier and colleagues recently described the expression of 1 1 5 S . m a n s o n i p r o t e i n s a n d s c r e e n e d t h e m f o r immunoreactivity with sera from human subjects who were experimentally infected with male parasites (48). However, to express 1,000 proteins in mammalian cells would require a Herculean effort and substantial funding and definitely is not considered high-throughput.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, there is a drive to develop a new generation of therapeutics based on schistosome genomes and their function (e.g. Berriman et al, 2009;Crosnier et al, 2020;Wang et al, 2020). Understanding the rhythms of target genes and their products will determine how an organ, or organism, will respond to a drug at a specific time of the day, and the timing of drug delivery could have a large impact on the effectiveness of target activation or inhibition (Cederroth et al, 2019).…”
Section: Discussionmentioning
confidence: 99%