Human Herpesvirus 8 Variants in Venezuelan Patients with AIDS‐Related Kaposi Sarcoma

Hernández, Dimas; Masquelier, Bernard; Pérez, Omidres; Oliver, Margarita; Fleury, Hervé

doi:10.1086/346041

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…This pattern of KSHV strain distribution has also been reported in Argentina (Meng et al, 2001), a South American country whose population is mostly composed of European descendants. However, we also found 7 (21%) patients, four of whom were not of African descent, infected with subtype B, a subtype which has been found mostly in subSaharan Africa (Cook et al, 1999(Cook et al, , 2002Kakoola et al, 2001;Lacoste et al, 2000) or among African descendants living in French Guiana , although there have been a few reports of occurrence in Venezuela (Hernàndez et al, 2003) and indeed three cases in Brazil (Caterino-deAraújo, 1998). We found two patients infected with subtype A5 (Bra/SP9 and Bra/SP84), one of Caucasian descent and one of Amazonian Amerindian descent (Figs.…”

Section: Discussionmentioning

confidence: 51%

Molecular characterization of Kaposi's sarcoma associated herpesvirus (KSHV) from patients with AIDS-associated Kaposi's sarcoma in São Paulo, Brazil

Nascimento

Wilder

Pannuti

et al. 2005

Journal of Clinical Virology

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Section: Discussionmentioning

confidence: 51%

Molecular characterization of Kaposi's sarcoma associated herpesvirus (KSHV) from patients with AIDS-associated Kaposi's sarcoma in São Paulo, Brazil

Nascimento

Wilder

Pannuti

et al. 2005

Journal of Clinical Virology

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“…There are five major KSHV genotypes described (A, B, C, D and E), mainly based on the hypervariable regions of the oncogenic K1 gene. Interestingly, in the series of studies from LA, while genotypes A, B and C [167,177,190,[200][201][202] were described in neoplasms or HIV positive cases, subtype E has been the sole genotype found in Amerindians from Ecuador, Brazil and French Guiana [190,195,197,[203][204][205]. Genotypes A and C are prevalent in Europe and North America, while genotype B is more prevalent in individuals with African ancestry [195].…”

Section: Kshv Prevalence and Morbidity In Latin Americamentioning

confidence: 99%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.

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“…In 2003 Hernandez et al 19 reported the molecular characterization of nine AIDS-related KS specimens. The results showed subtype B in five patients (56%), subtype C in three patients (33%), and subtype A in one patient (11%).…”

Section: Venezuelamentioning

confidence: 99%

Epidemiology and clinical characteristics of classic Kaposi's sarcoma, seroprevalence, and variants of human herpesvirus 8 in South America: A critical review of an old disease

Mohanna

Maco

Bravo

et al. 2005

International Journal of Infectious Diseases

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Classic KS in South America has a very similar clinical presentation but not the same as the classic KS variety described in the Mediterranean. Initial seroprevalence studies performed in the general population and in blood donors showed low seroprevalence of HHV-8, whereas high seroprevalence rates were seen in Amerindian population. The existing serological assays, nonetheless, need to be further refined, and new assays need to be developed. Finally, the key to understanding the precise molecular epidemiology and phylogenetic distribution of HHV-8 in South America would be to perform more subtyping of classic KS cases.

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Human Herpesvirus 8 Variants in Venezuelan Patients with AIDS‐Related Kaposi Sarcoma

Cited by 3 publications

References 8 publications

Molecular characterization of Kaposi's sarcoma associated herpesvirus (KSHV) from patients with AIDS-associated Kaposi's sarcoma in São Paulo, Brazil

Molecular characterization of Kaposi's sarcoma associated herpesvirus (KSHV) from patients with AIDS-associated Kaposi's sarcoma in São Paulo, Brazil

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Epidemiology and clinical characteristics of classic Kaposi's sarcoma, seroprevalence, and variants of human herpesvirus 8 in South America: A critical review of an old disease

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