Human erythrocytes are affected by the organochloride insecticide chlordane

Suwalsky, Mario; Rodríguez, Carola Gómez; Villena, Fernando Pardo-Manuel de; Sotomayor, Carlos P.

doi:10.1016/j.fct.2004.12.010

Cited by 17 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This inhibition leads to the accumulation of the neurotransmitter acetylcholine in nerves which interferes with muscular activities and the functioning of vital organs, produces serious symptoms, and may even lead to death [13,14]. Target site of other various pesticides are-human erythrocytes [15], reproduction and development system [16], endocrine system [17], liver, central nervous system, and immune system [18,19], etc. Thus, the analysis of pesticide residues is an important concern due to their bioaccumulation effect, high toxicity and their long-term damage risk to both the environment and lives even though their concentration is very low.…”

Section: Introductionmentioning

confidence: 99%

Biosensor Technology for Pesticides—A review

Verma

Bhardwaj

2015

Appl Biochem Biotechnol

244

139

View full text Add to dashboard Cite

Pesticides, due to their lucrative outcomes, are majorly implicated in agricultural fields for crop production enhancement. Due to their pest removal properties, pesticides of various classes have been designed to persist in the environment over a longer duration after their application to achieve maximum effectiveness. Apart from their recalcitrant structure and agricultural benefits, pesticides also impose acute toxicological effects onto the other various life forms. Their accumulation in the living system may prove to be detrimental if established in higher concentrations. Thus, their prompt and accurate analysis is a crucial matter of concern. Conventional techniques like chromatographic techniques (HPLC, GC, etc.) used for pesticides detection are associated with various limitations like stumpy sensitivity and efficiency, time consumption, laboriousity, requirement of expensive equipments and highly trained technicians, and many more. So there is a need to recruit the methods which can detect these neurotoxic compounds sensitively, selectively, rapidly, and easily in the field. Present work is a brief review of the pesticide effects, their current usage scenario, permissible limits in various food stuffs and 21st century advancements of biosensor technology for pesticide detection. Due to their exceptional performance capabilities, easiness in operation and on-site working, numerous biosensors have been developed for bio-monitoring of various environmental samples for pesticide evaluation immensely throughout the globe. Till date, based on sensing element (enzyme based, antibody based, etc.) and type of detection method used (Electrochemical, optical, and piezoelectric, etc.), a number of biosensors have been developed for pesticide detection. In present communication, authors have summarized 21st century's approaches of biosensor technology for pesticide detection such as enzyme-based biosensors, immunosensors, aptamers, molecularly imprinted polymers, and biochips technology. Also, the major technological advancements of nanotechnology in the field of biosensor technology are discussed. Various biosensors mentioned in manuscript are found to exhibit storage stability of biocomponent ranging from 30-60 days, detection limit of 10(-6) - 10(-16) M, response time of 1-20 min and applications of developed biosensors in environmental samples (water, food, vegetables, milk, and juice samples, etc.) are also discussed. Researchers all over the globe are working towards the development of different biosensing techniques based on contrast approaches for the detection of pesticides in various environmental samples.

show abstract

Section: Introductionmentioning

confidence: 99%

Biosensor Technology for Pesticides—A review

Verma

Bhardwaj

2015

Appl Biochem Biotechnol

244

139

View full text Add to dashboard Cite

show abstract

“…[22,23] Moreover, these techniques are unable to cleave the carbon-halogen bond, and there is still existence of halogenated compounds, which are one important type of toxic organic pollutants. [24,25] Other techniques such as sorption on activated carbon or retention by membranes may alternatively be employed to remove halogenated compounds in effluents, [21,[26][27][28][29][30] but still there is difficulty to solve the toxicity issue of the concentrated residual fraction. Though organochlorine respiring bacteria can be used to dechlorinate DCF, it is a very slow process that cannot be applied in the real water treatment.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and evaluation of Au–Pd core-shell nanocomposites for dechlorination of diclofenac in water

Wang

Lǐ

et al. 2015

Environmental Technology

View full text Add to dashboard Cite

Nanocomposites with core-shell structure usually exhibit excellent catalytic properties due to unique interfaces and synergistic effect among composites. In this study, Au-Pd bimetallic nanoparticles (NPs) with core-shell structure (Au-Pd cs) by using Au NPs as core and Pd as shell were successfully fabricated and, for the first time, were used to investigate the dechlorination of diclofenac (DCF) at H2 atmosphere in water at room temperature. The degradation products were studied as well by using HPLC/Q-ToF MS/MS. The operational factors such as pH and composition of the Au-Pd cs were also studied. The results showed that nearly 100% of DCF (30 mg L(-1), 50 mL, pH=7) was dechlorinated in 4.5 h by 10 mL of 56 mg L(-1) of Au-Pd cs. Ninety per cent of DCF was degraded in 6.5 h by the mixture of Au and Pd NPs. However, the individual Au NPs had no obvious effect in degrading DCF and the monometallic Pd NPs with comparable concentration only degraded less than 20% of DCF. Furthermore, the reaction mechanism of this catalytic process was studied in detail. It was found that the degradation was a second-order exponential reaction. The two main degradation products were obtained by cleaving the carbon-halogen bond of DCF and this made the degradation products more environmentally friendly.

show abstract

“…This kind of approach, namely application of artificial membranes is extensively used to investigate the Page 5 of 33 A c c e p t e d M a n u s c r i p t 5 mechanism of action and potential toxicity of various biologically active molecules. However, monolayer technique is also widely applied in the studies towards toxicity of various environmental pollutants and xenobiotics [24][25][26].…”

Section: Introductionmentioning

confidence: 99%