2001
DOI: 10.1095/biolreprod64.2.590
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Human Endometrial Mucin MUC1 Is Up-Regulated by Progesterone and Down-Regulated In Vitro by the Human Blastocyst1

Abstract: Expression of MUC1 in endometrial epithelium has been suggested to create a barrier to embryo attachment that must be lifted at the time of implantation. In this study, we investigated the hormonal regulation of human endometrial MUC1 in hormone replacement therapy cycles and in the human blastocyst. We also analyzed the embryonic regulation of MUC1 in human endometrial epithelial cells (EECs) during the apposition and adhesion phases of human implantation using two different in vitro models. Our results indic… Show more

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Cited by 295 publications
(230 citation statements)
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“…These stages correspond to the period of high plasma 244 progesterone and its associated dominance in the endometrial LE. These results agree with previous 245 reports of increased MUC1 expression under progesterone-dominated endometrial epithelium in 246 rabbit [35] and human [1]. Interestingly, we could detect a significant drop in MUC1 mRNA 247 expression at post LH peak stage which was also confirmed by immunostaining.…”
Section: Muc1 Protein Expression In Sheep Endometrium During Differensupporting
confidence: 89%
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“…These stages correspond to the period of high plasma 244 progesterone and its associated dominance in the endometrial LE. These results agree with previous 245 reports of increased MUC1 expression under progesterone-dominated endometrial epithelium in 246 rabbit [35] and human [1]. Interestingly, we could detect a significant drop in MUC1 mRNA 247 expression at post LH peak stage which was also confirmed by immunostaining.…”
Section: Muc1 Protein Expression In Sheep Endometrium During Differensupporting
confidence: 89%
“…In addition, our data has revealed a transient decline in 260 MUC1 mRNA and protein expression at the post-LH in both regions providing further evidence for 261 MUC1 dependency on steroid hormones [1]. This period coincides with the optimum insemination 262 time in sheep.…”
Section: Muc1 Protein Expression In Sheep Endometrium During Differensupporting
confidence: 63%
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