In vivo and in vitro studies of MUC1 regulation in sheep endometrium

Raheem, Kabir Ayobami; Marei, Waleed F.A.; Campbell, Bruce; Fouladi-Nashta, Ali A.

doi:10.1016/j.theriogenology.2016.01.018

Cited by 14 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MUC1 is a non-adhesive molecule whose regulation, expression and functions with regards to implantation vary according to species. In sheep, endometrial MUC1 expression is cyclically regulated by both oestrogen and progesterone in vivo and in vitro , and directly down regulated by interferon tau treatment in vitro [133]. Interferon tau is an agent of maternal recognition of pregnancy produced by the blastocyst to abrogate luteolysis in ruminants [134].…”

Section: Glycoprotein Mucin 1 (Muc1)mentioning

confidence: 99%

Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species

Raheem

2018

International Journal of Veterinary Science and Medicine

Self Cite

View full text Add to dashboard Cite

Implantation is one of the most critical steps in mammalian reproduction and implantation failure constitutes a major cause of infertility in both animals and humans. The mechanism of implantation is exclusively under the control of ovarian steroids progesterone and oestrogen whose actions are mediated in a complex phenomenon that involves a number of cytokines and growth factors. According to a plethora of literature on implantation in mammalian species, prominent of these cytokines and growth factor playing crucial roles in implantation include integrin, osteopontin, integrin, insulin-like growth factor and leukaemia inhibitory factor. Others are cluster domain 44, hyaluronan system and many non-adhesive molecules such as glycoprotein mucin 1. In this review, the specific roles played by these molecules are expatiated. Generally, they function as adhesive molecules that facilitate attachment of ligands/proteins on the trophectoderm to their respective receptors on endometrial luminal epithelia or vice versa. Sometimes, they also function as signalling molecules that enhance communication between implanting blastocyst and receptive endometrium. This is of particular importance in embryo culture and embryo transfer where in vitro derived blastocyst unlike the in vivo condition, is not exposed to these substances and hence, their absence may be partly responsible for the low implantation rate observed in the surrogate. Appreciation of the roles played by these cytokines, growth factors and molecules as revealed in this review will spur further research on these topics, facilitate their inclusion in embryo culture media (if positively required) and are considered as vital aspect while developing strategies to improve fertility.

show abstract

Section: Glycoprotein Mucin 1 (Muc1)mentioning

confidence: 99%

Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species

Raheem

2018

International Journal of Veterinary Science and Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…VAMP (vesicle-associated membrane protein 8), located on the vesicle membran termed V-SNARE, while syntaxin and SNAP, found on the plasma membrane, ar ferred to as t-SNARE. These SNARE proteins possess 60-amino acid coiled-coil dom The interactions between SNARE proteins not only ensure the specificity of binding tween adjacent plasma membranes but also supply the energy required for plasma m brane fusion [19][20][21]. Both syntaxin and VAMP proteins have transmembrane dom anchoring them in place, whereas SNAP proteins are tethered to the plasma memb via palmitoyl groups situated between their two SNARE structural domains.…”

Section: Mechanism Of the Secretion Of Mucin In Endometrial Epithelia...mentioning

confidence: 99%

Mechanism Underlying the Regulation of Mucin Secretion in the Uterus during Pregnancy

Zhou,

Tian,

2023

IJMS

View full text Add to dashboard Cite

The function of endometrial epithelial cells is to secrete various substances that are rich in growth factors and nutrients. These substances support both embryo implantation and its subsequent development into a fetus. A vast number of mucins are expressed in endometrial epithelial cells, and they play an important role in regulating the processes of embryo implantation, pregnancy, and parturition. Previous studies have shown that mucin forms a mucus layer covering endometrial epithelial cells, which helps resist damage from foreign bacteria and their toxins. Therefore, this article aims to investigate the location of mucins in the endometrium, the mechanism of mucin secretion by the endometrium, and the regulation of mucins in the uterine epithelium by reproductive hormones, as well as the role of mucins in the protection of the epithelium’s structure. This research aims to provide a foundational understanding for future studies on the role and mechanism of endometrial mucins throughout the pregnancy cycle.

show abstract

“…The luminal change is associated with the formation of nuclear clumps epithelial plaque 37 regulated by steroid hormones . Though the function is not well known, it is believed to have some nutritional benefit for the proposed implanted embryo through the 43 and non-human primates studies poorly44,45 understood in the human . Other related luminal biomarkers are MUC16 which has to be downregulated as well, L-Selectin,46,22 Heparin-binding growth factor (HBGF) .…”

mentioning

confidence: 99%

Endometrial receptivity: The journey so far

Osazee K,

Omorogiuw A

2019

Ibom Med J

View full text Add to dashboard Cite

Implantation is an act of coordinated interaction between the nascent blastocyst and a receptive endometrium mediated by the molecular and cellular interplay in a spatiotemporal manner. Though the advent of modern technology has enhanced the availability of relatively good quality embryos; the implantation rate has not positively correlated. Unlike the human embryo, the study of implantation is laden with ethical and technical challenges. Hence, most of the data on the process of implantation derived from animal studies. Unfortunately, there is wide variation in implantation process among animal species. Thus, cannot be transposed for a human. Hence, the in-vivo model remained the basis for the study of the mechanism of implantation. Research directed towards this direction may help in optimising the outcome of Assisted Reproduction Technology (ART).

show abstract

In vivo and in vitro studies of MUC1 regulation in sheep endometrium

Cited by 14 publications

References 39 publications

Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species

Cytokines, growth factors and macromolecules as mediators of implantation in mammalian species

Mechanism Underlying the Regulation of Mucin Secretion in the Uterus during Pregnancy

Endometrial receptivity: The journey so far

Contact Info

Product

Resources

About