Human Electroretinogram after Argon Laser Photocoagulation of Different Retinal Areas

Gjötterberg, Magnus; Blomdahl, Sven

doi:10.1159/000265106

Cited by 12 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As might be expected, photocoagulation therapy had a further negative effect with a reduction in ERG amplitudes that correlated closely with the number of laser burns, especially those close to the macula (16,36,37). No improvement was observed 3 months later (36).…”

Section: G Retinopathy Statussupporting

confidence: 65%

“…By the end of the study, those with PDR had very low or absent OP amplitudes particularly if the proliferative lesions were central rather than peripheral, a finding that was replicated in another study by Gjöt-terberg (35). As might be expected, photocoagulation therapy had a further negative effect with a reduction in ERG amplitudes that correlated closely with the number of laser burns, especially those close to the macula (16,36,37). No improvement was observed 3 months later (36).…”

Section: G Retinopathy Statussupporting

confidence: 55%

See 1 more Smart Citation

Seeing Beyond Retinopathy in Diabetes: Electrophysiological and Psychophysical Abnormalities and Alterations in Vision

et al. 1998

View full text Add to dashboard Cite

Section: G Retinopathy Statussupporting

confidence: 65%

Section: G Retinopathy Statussupporting

confidence: 55%

Seeing Beyond Retinopathy in Diabetes: Electrophysiological and Psychophysical Abnormalities and Alterations in Vision

et al. 1998

View full text Add to dashboard Cite

“…No consistent differences were found here between a and b wave reductions, contrary to previous findings of larger reduction in a wave than in b wave. 8 Detailed examination of the ERG data after PRP treatment revealed that the b wave was usually reduced to a value which in the normal retina was not expected to be preceded by an a wave. To illustrate this observation the relationship between the b wave and the a wave for one diabetic patient is plotted in Fig.…”

Section: Resultsmentioning

confidence: 99%

Retinal function of the diabetic retina after argon laser photocoagulation assessed electroretinographically.

Perlman¹,

Gdal-On²,

Miller³

et al. 1985

British Journal of Ophthalmology

View full text Add to dashboard Cite

SUMMARY Electroretinographic (ERG) responses were measured in diabetic patients before, during, and after panretinal photocoagulation treatment with argon laser. The laser applications reduced considerably the amplitudes of the a and b waves of the ERG. Moreover, the relationship between the amplitude of the b wave and that of the a wave was severely affected, resulting in ERG responses of abnormal pattern. The b waves were smaller than expected from the a waves. These findings indicated that the photocoagulation treatment not only destroyed the retinal areas directly illuminated by the laser beam, but also affected the functional integrity of adjacent areas. These additional effects resulted in subnormal signal transmission from the photoreceptors to the proximal retina.Panretinal photocoagulation (PRP) has become an accepted treatment for diabetic retinopathy aimed at reducing the risk of blindness.' The intention of this therapy is to destroy a substantial portion of the peripheral retina in order to reduce the difference between oxygen demand and oxygen supply and thus to reduce the stimulus for neovascularisation.2 The extent of retinal destruction by the PRP treatment may determine its effectiveness. The electroretinogram (ERG) reflects retinal activity as a mass response and is generally used as an objective index of retinal function.34 Therefore many investigators have measured the electrical responses of the diabetic retina after photocoagulation.5-"' In these studies the amplitudes of the a and b waves were used as criteria for retinal destruction. There was no agreement among the different studies. In one report a 10-95% b wave deterioration was observed in different patients who were treated similarly.6 This variability was explained by variability in the extent of the effective retinal ablation. Similar lack of direct relationship between the number of laser applications and the reduction in the ERG amplitude was reported by others.7 Another report concluded that the a wave was reduced more than the b wave,8 thus supporting the notion that the laser application Correspondence to

show abstract

“…Liang et al 7 and Han et al 9 found a greater reduction in b wave absolute amplitudes than a wave, with Perlman et al 8 demonstrating proportional changes in the absolute amplitudes of both waves. Gjotterberg et al 6 demonstrated a greater reduction in the percentage change of a-wave amplitudes. The results outlined herein demonstrated a greater absolute change in b-wave amplitude, although there was a greater percentage change in a-wave amplitude.…”

Section: Discussionmentioning

confidence: 95%

“…Although prior studies have investigated the effect of PRP on ERG response, post-treatment response was assessed after completion of full PRP treatment. [5][6][7][8][9] The study presented herein sought to characterize how ERG measures change over the course of sequential PRP treatments in an effort to quantify the additive effect of progressive laser treatment.…”

Section: Introductionmentioning

confidence: 99%

<p>Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy</p>

Khojasteh¹,

Vishte²,

Mirzajani³

et al. 2020

OPTH

View full text Add to dashboard Cite

Purpose: To evaluate changes in electroretinogram (ERG) response over the course of multiple sessions of panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PRP). Methods: A prospective cohort study of 11 patients with PDR who required PRP was conducted. PRP was completed over three sessions. Each patient had five ERGs done: baseline, 1 week after each PRP session, and 6 weeks after the last session of PRP. Darkadapted 0.01 ERG, Dark-adapted 3 ERG, Dark-adapted 10 ERG, Light-adapted 3 ERG, and Light-adapted 30 Hz flicker ERG were done. The mean change in a-and b-wave amplitudes as well as implicit times compared to baseline was analyzed. Results: A significant reduction in peak amplitudes of both a-and b-waves and delay in latencies were observed in all responses (p<0.05). The absolute amplitude reduction and delay in latency were higher for scotopic b-waves (p<0.05). The root mean square (RMS) of Dark-adapted 10.0 ERG (p<0.05) and total mean amplitude changes of a-and b-waves (p<0.001) were reduced after each laser session; however, the magnitude of change was not different between the first, second, or third sessions of PRP, and each session showed a similar deterioration rate of ERG parameters comparing to each other (p=0.4 for RMS and p=0.2 for total mean amplitude changes). In addition, the results indicated recovery of the amplitude and latency of ERG waves after 6 weeks from the final treatment (p<0.001) although not to baseline levels. Conclusion: ERG findings following PRP show reduced retinal function after each session which partially recovers by 6 weeks after the completion of therapy. Clinicians should be mindful of these changes when planning the treatment course for patients with PDR.

show abstract

Human Electroretinogram after Argon Laser Photocoagulation of Different Retinal Areas

Cited by 12 publications

References 4 publications

Seeing Beyond Retinopathy in Diabetes: Electrophysiological and Psychophysical Abnormalities and Alterations in Vision

Seeing Beyond Retinopathy in Diabetes: Electrophysiological and Psychophysical Abnormalities and Alterations in Vision

Retinal function of the diabetic retina after argon laser photocoagulation assessed electroretinographically.

<p>Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy</p>

Contact Info

Product

Resources

About