<p>Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy</p>

Abstract

Purpose: To evaluate changes in electroretinogram (ERG) response over the course of multiple sessions of panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PRP). Methods: A prospective cohort study of 11 patients with PDR who required PRP was conducted. PRP was completed over three sessions. Each patient had five ERGs done: baseline, 1 week after each PRP session, and 6 weeks after the last session of PRP. Darkadapted 0.01 ERG, Dark-adapted 3 ERG, Dark-adapted 10 ERG, Light-adapted 3 ERG, and Light-adapted 30 Hz flicker ERG were done. The mean change in a-and b-wave amplitudes as well as implicit times compared to baseline was analyzed. Results: A significant reduction in peak amplitudes of both a-and b-waves and delay in latencies were observed in all responses (p<0.05). The absolute amplitude reduction and delay in latency were higher for scotopic b-waves (p<0.05). The root mean square (RMS) of Dark-adapted 10.0 ERG (p<0.05) and total mean amplitude changes of a-and b-waves (p<0.001) were reduced after each laser session; however, the magnitude of change was not different between the first, second, or third sessions of PRP, and each session showed a similar deterioration rate of ERG parameters comparing to each other (p=0.4 for RMS and p=0.2 for total mean amplitude changes). In addition, the results indicated recovery of the amplitude and latency of ERG waves after 6 weeks from the final treatment (p<0.001) although not to baseline levels. Conclusion: ERG findings following PRP show reduced retinal function after each session which partially recovers by 6 weeks after the completion of therapy. Clinicians should be mindful of these changes when planning the treatment course for patients with PDR.

A Paradigm Shift in the Management Approaches of Proliferative Diabetic Retinopathy: Role of Anti-VEGF Therapy

“…27 , 35 The electroretinogram findings over the course of multiple PRP sessions demonstrated decreased retinal function after each session that partially recovers by 6 weeks after the completion of therapy. 36 However, the complications associated with PRP are mostly attributable to inadequate PRP and could be minimised by conducting multiple PRP sessions rather than one session. The risk factors are further aggravated due to the use of short duration and high-intensity burns.…”

Quantitative evaluation of the supercontinuum laser eye dazzling effect: in vivo experimental research

“…It is a functional measurement tool for visual function changes [20], [21] . Furthermore, it is also a useful method of laser eye treatment for panretinal photocoagulation [22]- [24] . Hence, it would be a useful tool for evaluating the biological effect of laser dazzling of different kinds of lasers.…”