Human Clinical and Histologic Responses to Durapatite Implants in Intraosseous Lesions: Case Reports

Froum, Stuart J.; Kushner, Leslie; Scopp, Irwin Walter; Stahl, S. S.

doi:10.1902/jop.1982.53.12.719

Cited by 113 publications

(34 citation statements)

References 13 publications

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“…This is in agreement with previous reports showing that Ca-P ceramics induce little or no inflammation [22][23][24][25]. Newly formed bone appears shortly after implantation together with signs of cellular resorption of the newly formed bone as well as the biomaterials.…”

Section: Discussionsupporting

confidence: 93%

Cellular response to calcium phosphate ceramics implanted in rabbit bone

Basle¹,

Rèbel²,

Grizon³

et al. 1993

J Mater Sci: Mater Med

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Two hydroxyapatite ceramics, synthesized by sintering from bovine bone and from a mixture of phosphate tricalcium and natural hydroxyapatite, were implanted in bone sites in rabbits. From day 7 after implantation, osteoblast-like cells were visible with thin layers of new bone on both biomaterials. Histomorphometry showed progressive increase in volume and surface of newly formed bone. Signs of cell-dependent resorption were visible at the surface of biomaterials and newly formed bone. There was a progressive decrease in relative volume and trabecular thickness of the biomaterials. Resorption of biomaterials appears to involve two cell types: multinucleated giant cells and osteoclast-like cells. The multinucleated giant cells observed had neither tartrate resistant acid phosphatase activity (TRAP) nor a ruffled border. Vesicles and vacuoles containing crystals observed in these cells suggest phagocytosis of biomaterials. The number of these cells decreased after day 14 following implantation. The osteoclast-like cells were TRAP positive. The structured modification and the TRAP activity demonstrated in the subjacent biomaterial suggest that the dissolution of the implant may be associated to an extracellular enzymatic activity of these cells. Electron microscopy revealed a clear zone and cytoplasmic membrane infolding in these cells, suggesting a ruffled border differentiation. The number of these cells increased with delay after implantation. It was concluded that the implantation of calcium phosphate ceramics in bone leads to new bone formation as well as to resorption of the biomaterials. The mechanism of resorption appears to associate crystal endocytosis by multinucleated giant cells and more classical resorption by osteoclast-like cells.

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Section: Discussionsupporting

confidence: 93%

Cellular response to calcium phosphate ceramics implanted in rabbit bone

Basle¹,

Rèbel²,

Grizon³

et al. 1993

J Mater Sci: Mater Med

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“…Detailed chemical structures of HAp and other ion-substituted HAp can be found in recent reviews [3][4][5][6][7][8][9] and books [10][11][12][13]. Traditional HAp sintered ceramics (in dense, porous and powder forms) have been used in medical and dental fields [13][14][15][16], and the applications include alveolar ridge reconstruction and augmentation [17,18], fillers for bone defects [19][20][21][22], middle ear implant [23], etc. HAp is bioactive (osteoconductive), that is, HAp can encourage bone growth along its surface when placed in the vicinity of viable bone or differentiated bone-forming cells [11].…”

Section: Introductionmentioning

confidence: 99%

Hydroxylapatite nanoparticles: fabrication methods and medical applications

Okada

Furuzono

2012

Science and Technology of Advanced Materials

126

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Hydroxylapatite (or hydroxyapatite, HAp) exhibits excellent biocompatibility with various kinds of cells and tissues, making it an ideal candidate for tissue engineering, orthopedic and dental applications. Nanosized materials offer improved performances compared with conventional materials due to their large surface-to-volume ratios. This review summarizes existing knowledge and recent progress in fabrication methods of nanosized (or nanostructured) HAp particles, as well as their recent applications in medical and dental fields. In section 1, we provide a brief overview of HAp and nanoparticles. In section 2, fabrication methods of HAp nanoparticles are described based on the particle formation mechanisms. Recent applications of HAp nanoparticles are summarized in section 3. The future perspectives in this active research area are given in section 4.

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“…Although some allografts 5 and xenografts 6 reportedly are osteoinductive 5 or osteoconductive, their effects on periodontal regeneration remain inconsistent, 7 and their use is controversial because of the risk for contamination 1,4 . Hydroxyapatite (HA) 8,9 and tricalcium phosphate (TCP) 10,11 are popular alloplastic materials because of their handling characteristics and ready availability in various sizes. Nevertheless, histologic findings revealed that HA and TCP application resulted in the reformation of a long junctional epithelium along the root surfaces with no or limited periodontal regeneration and residual materials 1,8‐11 …”

mentioning

confidence: 99%