Human Cardiovascular and Metabolic Response to Acute, Severe Isovolemic Anemia

Weiskopf, Richard B.; Viele, Maurene; Feiner, John; Kelley, Scott D.; Lieberman, Jeremy A.; Noorani, Mariam; Leung, Jacqueline M.; Fisher, Dennis M.; Murray, William R.; Toy, Pearl; Moore, Mark A.

doi:10.1097/00132586-199812000-00042

Cited by 69 publications

(93 citation statements)

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“…These mechanisms consist of internal hemodilution, increased heart rate, and centralized blood flow toward the vital organs like the brain (Menke et al 2004). As in blood withdrawal, severe isovolemic anemia induced significant human cardiovascular and metabolic responses (Weiskopf et al 1998), impairs cognitive function and memory (Weiskopf et al 2000(Weiskopf et al , 2002. Further, healthy humans who underwent acute blood loss to an Hb level of 50 g/l had increased P300 latency, which was associated with impaired brain cognitive function (Weiskopf et al 2005).…”

Section: Introductionmentioning

confidence: 99%

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

Zhang

Zhang²,

Yang

et al. 2011

Brain Topogr

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The aim of this study was to investigate the effect of 400 ml whole blood donation on the human electroencephalogram (EEG) and hematology, not earlier reported in the literature. EEG activity was recorded from ten male blood donors (experiment group) before, during and after blood donation (i.e., 400 ml whole blood withdrawal). EEG topography and regional spectral field powers analyses were carried out via fast Fourier transformation. The venous hemoglobin (Hb) concentration was measured with a hematology analyzer. In the control investigation, 12 male age-matched volunteers (control group) were kept in semi-sitting position for the duration of a blood donation without actually vena puncture. The volunteers had no prior experiences of blood donation. Within the experiment group, post-donation Hb concentration decreased by 3.7% compared with the pre-donation Hb values (P < 0.01). Before blood donation, Hb concentration in control group was significantly higher compared to the experiment group (P < 0.05). For the experiment group, the field power of alpha-1 (7.5-9.5 Hz) EEG during blood withdrawal was significantly lower compared to that after blood withdrawal (P < 0.05). In contrast for the control group, all seven bands of regional spectral field powers showed no significantly discrepancies in the three periods. Blood donation attenuates the alpha-1 at the parietal-frontal area on human EEG-DMN transiently with no lasting effect at post-donation period. The blood donation-related effects on brain function may be of little consequence due to slight hemodynamic change and the results may facilitate the opinion that blood donation is a safe process and that should not discourage volunteers.

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Section: Introductionmentioning

confidence: 99%

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

Zhang

Zhang²,

Yang

et al. 2011

Brain Topogr

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“…Although the resting human heart can withstand acute severe isovolemic anemia as low as 5.0 g/dl [13], CV disease significantly impairs the heart's ability to tolerate low levels of hemoglobin [4].…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin levels and 30-day mortality in patients after myocardial infarction

Lipšic

Horst

Voors

et al. 2005

International Journal of Cardiology

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“…Taken together these mechanisms provide adequate oxygenation in healthy volunteers at rest to a [Hb] as low as 5 g/dl. 8,9 These protective mechanisms also appear to apply to patients with known coronary artery disease (CAD) although no studies in such patients have assessed the effects on myocardial oxygenation below a [Hb] of 9 g/dl. 10,11 Animal studies, with the creation of artificial coronary stenosis, suggest that myocardial oxygenation may be maintained in instances of dilutional anaemia as a result of increased trans-stenotic flow rates due to a reduction in blood viscosity.…”

Section: Reduction In Body Weight Was Associated With An Increase In mentioning

confidence: 99%

The Effect of Gain in Total Body Water on Haemoglobin Concentration and Body Weight Following Cardiac Surgery

Slight

Demosthenous

Nzewi

et al. 2006

Heart, Lung and Circulation

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Human Cardiovascular and Metabolic Response to Acute, Severe Isovolemic Anemia

Cited by 69 publications

References 0 publications

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

Hemoglobin levels and 30-day mortality in patients after myocardial infarction

The Effect of Gain in Total Body Water on Haemoglobin Concentration and Body Weight Following Cardiac Surgery

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