The Impact of a Regular Blood Donation on the Hematology and EEG of Healthy Young Male Blood Donors

Abstract

The aim of this study was to investigate the effect of 400 ml whole blood donation on the human electroencephalogram (EEG) and hematology, not earlier reported in the literature. EEG activity was recorded from ten male blood donors (experiment group) before, during and after blood donation (i.e., 400 ml whole blood withdrawal). EEG topography and regional spectral field powers analyses were carried out via fast Fourier transformation. The venous hemoglobin (Hb) concentration was measured with a hematology analyzer. In the control investigation, 12 male age-matched volunteers (control group) were kept in semi-sitting position for the duration of a blood donation without actually vena puncture. The volunteers had no prior experiences of blood donation. Within the experiment group, post-donation Hb concentration decreased by 3.7% compared with the pre-donation Hb values (P < 0.01). Before blood donation, Hb concentration in control group was significantly higher compared to the experiment group (P < 0.05). For the experiment group, the field power of alpha-1 (7.5-9.5 Hz) EEG during blood withdrawal was significantly lower compared to that after blood withdrawal (P < 0.05). In contrast for the control group, all seven bands of regional spectral field powers showed no significantly discrepancies in the three periods. Blood donation attenuates the alpha-1 at the parietal-frontal area on human EEG-DMN transiently with no lasting effect at post-donation period. The blood donation-related effects on brain function may be of little consequence due to slight hemodynamic change and the results may facilitate the opinion that blood donation is a safe process and that should not discourage volunteers.

Spectral specific standardized low-resolution brain electromagnetic tomography default mode connectivity network and plasticity alterations in left vertebral artery stent patients

“…Our previous study showed during blood donation, alpha-1 at the parietalfrontal area on human EEG-DMN transiently with no lasting effect at the post-donation period. 31 In this study, the reverse process of cerebral blood supply did not observe alpha-1 alterations but alpha-2 changes, even alpha-2 did not attain statistical differences. Similar changes existed in delta band spectra, delta intensity was increased in the pre-LVAS group compared with the control group, and the changes were attenuated in the post-LVAS group, which were in accordance with previous cerebral stroke patients EEG alteration.…”

Different effects of propofol and dexmedetomidine sedation on electroencephalogram patterns: Wakefulness, moderate sedation, deep sedation and recovery

“…After data collection, the EEG was analyzed offline with EEG lab 14.0 software as Zhang et al described[ 20 , 21 ]. Briefly, all EEG data were filtered offline with a 0.5–100 Hz bandpass filter for analysis.…”