Human Basophils and Cytokines/Chemokines

Yamaguchi, Masao; Koketsu, Rikiya; Suzukawa, Maho; Kawakami, Ayako; Iikura, Motoyasu

doi:10.2332/allergolint.08-rai-0056

Cited by 21 publications

(14 citation statements)

References 63 publications

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“…Human basophils display a large number of chemokine receptors on their surface, some of which induce mediator release (CCR2) and many others (CXCR1, CXCR2, CXCR4, CCR1, CCR3, and CCR5) elicit basophil chemotaxis. Human basophils express several α‐ and β‐integrins that modulate basophil adhesion to endothelium and extravasation . IL‐3 upregulates the expression of β2‐integrins thereby potentiating the adherence of basophils to the endothelium .…”

Section: Chemokines and Chemoattractant Receptorsmentioning

confidence: 99%

“…Human basophils express several α-and β-integrins that modulate basophil adhesion to endothelium and extravasation. 254 IL-3 upregulates the expression of β2-integrins thereby potentiating the adherence of basophils to the endothelium. 70 Surface CXCR4 expression is not detected in fresh basophils, but it appears during short-term incubation.…”

Section: Cytokinesmentioning

confidence: 99%

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Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

126

116

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Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies.

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Section: Chemokines and Chemoattractant Receptorsmentioning

confidence: 99%

Section: Cytokinesmentioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

126

116

View full text Add to dashboard Cite

show abstract

“…In case of an infection, mature basophils degranulate and release histamine, proteoglycans (both prestored), the cytokines IL-3, IL-4, IL-6, IL-9, IL-13, IL-25, and GM-CSF, proteolytic enzymes, lipid mediators, and the chemokines MCP-1, MIP-1α, MIP-1β, and RANTES. However, basophils do not release the immunregulatory cytokines IFN-γ, IL-17, or IL-5 (Schroeder et al, 2009; Yamaguchi et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells

Schorn¹,

Janko²,

Latzko³

et al. 2012

Front. Immun.

154

128

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Neutrophil extracellular traps (NETs) are fibers of extracellular DNA released from neutrophils due to overwhelming phagocytic stimuli. The function of NETs is to trap and kill microbes to avoid spreading of potential pathogens. NETs are formed after encounter with various gram-positive and -negative bacteria but also in response to mediators causing sterile inflammation like interleukin-8 (IL-8), tumor necrosis factor (TNF), and phorbol myristate acetate (PMA). Here we show the formation of NETs (NETting) in response to monosodium urate (MSU) crystals as further model for sterile inflammation. We identified monocytes, neutrophils, and eosinophils as MSU phagocytosing cells. Basophils did not take up the crystals, instead they upregulated their activation marker CD203c after contact with MSU. Nevertheless, MSU crystals induced extracellular trap formation also in basophils, like in eosinophils and neutrophils, which phagocytose the crystals. In contrast, monocytes do not form NETs despite uptake of the MSU crystals. In contrast to the canonical stimuli like bacteria and PMA, MSU-induced NETosis was not abrogated by plasma. Our data show that MSU crystals induce extracellular DNA trap formation in all three granulocytes lineages (NETs, EETs, and BETs) but not in monocytes, and DNA externalization does not necessitate the uptake of the crystals.

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“…The same was observed with the lipid mediators 5-oxo-eicosatetraenoic acid and PAF. IL-3 presumably positively affects the expression of the β 2 integrin and surface matrix metalloproteinase MMP-9 which cooperatively help basophils to cross the basement membrane [130, 131, 134]. …”

Section: The Basophil In the Immune Networkmentioning

confidence: 99%

The Evolution of Human Basophil Biology from Neglect towards Understanding of Their Immune Functions

Steiner

Huber

Harrer

et al. 2016

BioMed Research International

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Being discovered long ago basophils have been neglected for more than a century. During the past decade evidence emerged that basophils share features of innate and adaptive immunity. Nowadays, basophils are best known for their striking effector role in the allergic reaction. They hence have been used for establishing new diagnostic tests and therapeutic approaches and for characterizing natural and recombinant allergens as well as hypoallergens, which display lower or diminished IgE-binding activity. However, it was a long way from discovery in 1879 until identification of their function in hypersensitivity reactions, including adverse drug reactions. Starting with a historical background, this review highlights the modern view on basophil biology.

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Human Basophils and Cytokines/Chemokines

Cited by 21 publications

References 63 publications

Human mast cells and basophils—How are they similar how are they different?

Human mast cells and basophils—How are they similar how are they different?

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells

The Evolution of Human Basophil Biology from Neglect towards Understanding of Their Immune Functions

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