Human B Cell-Attracting Chemokine 1 (Bca-1; Cxcl13) Is an Agonist for the Human Cxcr3 Receptor

Jenh, Chung‐Her; Cox, Mary Ann; Hipkin, William; Lu, Tianhong; Pugliese-Sivo, Catherine; Gonsiorek, Waldemar; Chou, Chuan‐Chu; Narula, Satwant K.; Zavodny, Paul J.

doi:10.1006/cyto.2001.0923

Cited by 74 publications

(50 citation statements)

References 27 publications

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“…Fourth, it was previously found that CXCL13/BLC is an additional chemotactic ligand for CXCR3. 33 Our DNA filter array data showed a large increase in CXCL13/BLC mRNA expression in spleen during SIV-associated disease progression (Figure 1), and this might also provide a positive signal that contributes to the maintenance of the IFN-␥-driven positive-feedback loops (step 6). Preliminary ISH studies examining CXCL13/BLC mRNA expression directly in tissue sections also found increased expression in spleens of macaque with AIDS (data not shown).…”

Section: Discussionmentioning

confidence: 85%

Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-γ in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome

Reinhart

Fallert

Pfeifer

et al. 2002

Blood

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Section: Discussionmentioning

confidence: 85%

Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-γ in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome

Reinhart

Fallert

Pfeifer

et al. 2002

Blood

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“…It is widely known that CXCR5 is the main CXCL13 receptor (30) and CXCR3 is a receptor potentially able to bind CXCL13 (31). The expression of these two molecules was evaluated by qRT-PCR and FACS analysis in circulating SS cells ( Fig.…”

Section: Resultsmentioning

confidence: 99%

CXCL13 Is Highly Produced by Sézary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines

et al. 2008

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Chemokine and chemokine receptors expressed by normal and neoplastic lymphocytes play a key role in cell recruitment into skin and lymph nodes. The aim of this study was to get further insights into the role of chemokines in pathogenesis and progression of cutaneous T-cell lymphoma (CTCL) with particular regard to Sézary Syndrome (SS), a CTCL variant with blood involvement. Here, we show that functional CXCL13 homeostatic chemokine is strongly up-regulated in SS cells, well-detectable in skin lesions and lymph nodes, and measurable at high concentration in plasma of SS patients, at different levels during disease progression. Furthermore, we show that the addition of CXCL13 to CCL19 or to CCL21, the selective CCR7 agonists responsible for lymph node homing, strongly enhances the migration of CCR7+ SS cells. We also show that neutralization of the CCR7 receptor strongly impairs CCL19/21-induced chemotaxis of SS cells both in the absence or presence of CXCL13. Additional experiments performed to investigate the survival, adhesion, and metalloproteases secretion indicate that CXCL13 combined with CCL19 and CCL21 mainly affects the chemotaxis of SS cells. Our findings suggest that this newly described CXCL13 expression in SS represents a new pathogenetic mechanism of diagnostic significance. [Cancer Res 2008;68(17):7137-46]

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“…It has been reported in human systems that BCA-1/CXCL13 can mediate chemotaxis through CXCR3 in addition to CXCR5 (48). As NKT cells express high levels of CXCR3 (Fig.…”

Section: Bca-1/cxcl13-induced Nkt Cell Chemotaxis Is Dependent On Cxcr5mentioning

confidence: 86%

Differential Chemokine Responses and Homing Patterns of Murine TCRαβ NKT Cell Subsets

Johnston

Kim

Soler

et al. 2003

The Journal of Immunology

156

139

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NKT cells play important roles in the regulation of diverse immune responses. Therefore, chemokine receptor expression and chemotactic responses of murine TCRαβ NKT cells were examined to define their homing potential. Most NKT cells stained for the chemokine receptor CXCR3, while >90% of Vα14i-positive and ∼50% of Vα14i-negative NKT cells expressed CXCR6 via an enhanced green fluorescent protein reporter construct. CXCR4 expression was higher on Vα14i-negative than Vα14i-positive NKT cells. In spleen only, subsets of Vα14i-positive and -negative NKT cells also expressed CXCR5. NKT cell subsets migrated in response to ligands for the inflammatory chemokine receptors CXCR3 (monokine induced by IFN-γ/CXC ligand (CXCL)9) and CXCR6 (CXCL16), and regulatory chemokine receptors CCR7 (secondary lymphoid-tissue chemokine (SLC)/CC ligand (CCL)21), CXCR4 (stromal cell-derived factor-1/CXCL12), and CXCR5 (B cell-attracting chemokine-1/CXCL13); but not to ligands for other chemokine receptors. Two NKT cell subsets migrated in response to the lymphoid homing chemokine SLC/CCL21: CD4− Vα14i-negative NKT cells that were L-selectinhigh and enriched for expression of Ly49G2 (consistent with the phenotype of most NKT cells found in peripheral lymph nodes); and immature Vα14i-positive cells lacking NK1.1 and L-selectin. Mature NK1.1+ Vα14i-positive NKT cells did not migrate to SLC/CCL21. BCA-1/CXCL13, which mediates homing to B cell zones, elicited migration of Vα14i-positive and -negative NKT cells in the spleen. These cells were primarily CD4+ or CD4−CD8− and were enriched for Ly49C/I, but not Ly49G2. Low levels of chemotaxis to CXCL16 were only detected in Vα14i-positive NKT cell subsets. Our results identify subsets of NKT cells with distinct homing and localization patterns, suggesting that these populations play specialized roles in immunological processes in vivo.

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Human B Cell-Attracting Chemokine 1 (Bca-1; Cxcl13) Is an Agonist for the Human Cxcr3 Receptor

Cited by 74 publications

References 27 publications

Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-γ in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome

Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-γ in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome

CXCL13 Is Highly Produced by Sézary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines

Differential Chemokine Responses and Homing Patterns of Murine TCRαβ NKT Cell Subsets

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