Hubungan Subtipe Sel Limfosit dengan Tingkat Remisi Pascakemoterapi Fase Induksi Leukemia Limfoblastik Akut

Suryawan, Nur; Idjradinata, Ponpon; Reniarti, Lelani

doi:10.14238/sp18.6.2017.448-52

Cited by 4 publications

(4 citation statements)

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“…Three studies showed a mortality rate between 1–2 deaths per 100,000 children per year. These studies originate from Bandung [ 35 ], Jakarta [ 38 ], and Surabaya [ 41 ], with a mortality rate of 1.75, 1.8, and 1.86 deaths per 100,000 children, respectively. The remaining three studies from the Special District of Yogyakarta [ 36 ], Makassar [ 40 ], and Denpasar [ 46 ] have a mortality rate of 2.76, 2.1, and 2.3 deaths per 100,000 children, respectively.…”

Section: Resultsmentioning

confidence: 99%

The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis

et al. 2022

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Background The incidence of childhood ALL in Indonesia is still largely unknown. The widely mentioned statistics from other countries turn out to be only estimated figures. Other data do not specify the types of leukemia and are not specifically focused on children. Therefore, this study aims to pool incidence and mortality statistics from available studies in Indonesia. Methods We searched five different academic databases, including Pubmed, MEDLINE, Cochrane Library, Science Direct, and Google Scholar. Three Indonesian databases, such as the Indonesian Scientific Journal Database (ISJD), Neliti, and Indonesia One Search, were also utilized. Incidence was expressed as per 100,000 children. We used the Newcastle-Ottawa scale (NOS) to assess the quality of cohort studies. The inclusion criteria are cohort studies published in the languages of English or Indonesian. For this analysis, we define children as 0–18 years old. Findings The incidence rate for childhood ALL was found to be 4.32 per 100,000 children (95% CI 2.65–5.99) with a prediction interval of 1.98 to 9.42 per 100,000 children. The incidence rate is higher in males, with 2.45 per 100,000 children (95% CI 1.98–2.91) and a prediction interval of 1.90 to 3.16 per 100,000 children. As for females, the incidence rate is 2.05 per 100,000 children (95% CI 1.52–2.77) with a prediction interval of 1.52 to 2.77 per 100,000 children. The mortality of childhood ALL ranges from 0.44 to 5.3 deaths per 100,000 children, while the CFR is 3.58% with varying true effect sizes of 2.84% to 4.52%. Interpretation With 79.5 million children living in Indonesia in 2018, this means that there were roughly 3,434 new cases of childhood ALL. An organized effort between multiple sectors is needed to improve the registries of childhood ALL in Indonesia.

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Section: Resultsmentioning

confidence: 99%

The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis

et al. 2022

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“…Leukemia limfoblastik akut adalah penyakit keganasan bercirikan khas infiltrasi progresif sel limfoid imatur (limfoblas) pada sumsum tulang dan organ limfatik. 9 Leukemia limfoblastik akut merupakan tipe leukemia yang paling banyak ditemukan pada anak. 1,10 Berdasar atas hasil data yang diperoleh pasien LLA di RS Al Islam yang berusia <5 tahun sebanyak 41 (55%) merupakan pasien LLA terbanyak.…”

Section: Pembahasanunclassified

Karakteristik dan Jumlah Leukosit pada Anak Penderita Leukemia Limfoblastik Akut yang Menjalani Kemoterapi Fase Induksi di Rumah Sakit Al Islam Bandung

2021

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Leukemia limfoblastik akut (LLA) adalah kelompok keganasan heterogen dengan sejumlah kelainan genetik khas yang menghasilkan berbagai perilaku klinis dan respons terhadap terapi. Pasien LLA pada umumnya identik dengan jumlah leukosit yang tinggi, terapi saat ini adalah dengan cara kemoterapi yang terdiri atas 3 fase, yaitu induksi, konsolidasi, dan pemeliharaan. Keberhasilan kemoterapi ditentukan banyak faktor antara lain adalah terjadi remisi setelah kemoterapi fase induksi. Penelitian ini bertujuan mengetahui karakteristik dan jumlah leukosit pada anak penderita LLA setelah fase induksi kemoterapi. Metode yang digunakan adalah deskriptif dengan rancangan potong lintang yang menggunakan data rekam medik pasien LLA periode tahun 2019 usia 0 - 15 tahun. Penelitian ini dilaksanakan selama bulan Oktober 2020, teknik pengambilan data menggunakan total sampling. Pada penelitian ini didapatkan 137 data rekam medik, data yang memenuhi kriteria inklusi sebanyak 74 data. Kasus LLA paling banyak terjadi pada usia 0 - 5 tahun pada 41 pasien (55%), jenis kelamin laki-laki 43 pasien (58%), status gizi baik 46 pasien (62%), morfologi sumsum tulang remisi 63 pasien (85%), dan jumlah leukosit 4500-13500/mm3 pada 52 pasien (70%), remisi sumsum tulang terbanyak pada jumlah leukosit 4 pada 45 pasien (61%). Simpulan, karakteristik pasien LLA terba500-13500/mm3nyak laki-laki, usia 0 - 5 tahun status gizi baik dan morfologi sumsum tulang remisi. Characteristics and Number of Leukocytes in Children with Acute Lymphoblastic Leukemia who Underwent Induction Phase Chemotherapy at Al Islam Hospital BandungAcute lymphoblastic leukemia (ALL) is a heterogeneous group of malignancies with a number of characteristic genetic disorders that produce a variety of clinical behaviors and responses to therapy. LLA patients are generally synonymous with high leukocyte counts. Current therapy is chemotherapy which consists of 3 phases, namely induction, consolidation, and maintenance. The success of chemotherapy is determined by many factors, including remission after induction phase chemotherapy. This study aims to determine the characteristics and number of leukocytes in children with LLA after the chemotherapy induction phase. The method used was descriptive with a cross-sectional design using medical records of LLA patients periode 2019 aged 0-15 years. study was held in October 2020. In this study, there were 137 medical record data, data that met the inclusion criteria were 74 data. LLA cases in this study mostly occurred at the age of 0 - 5 years, amounting to 41 patients (55%), male gender totaled 43 patients (58%), good nutritional status totaled 46 patients (62%). ), the morphology of bone marrow remission totaled 63 patients (85%), and for the number of leukocytes 4500 - 13500/mm3 as many as 52 patients (70%), the greatest occurrence of bone marrow remission was in the number of leukocytes 4500/mm3-13500/mm3 as many as 45 patients (61%). In conclusion, characteristics of most ALL patients are male, age of 0 - 5 years with good nutritional status and bone marrow morphology showing remission. Characteristics and Number of Leukocytes in Children with Acute Lymphoblastic Leukemia who Underwent Induction Phase Chemotherapy at Al Islam Hospital Bandung

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“…3 It is also one of the malignancies with high incidence rate in Indonesia, as shown in Dr. Hasan Sadikin General Hospital reports where fifty-one new cases of ALL had been found in 2010-2011, while 76 new cases were found in 2014. 5,6 It is known that half of the pediatric patients with malignancy in 2006 had been admitted to Dharmais National Cancer Hospital with advanced stage condition. Lack of knowledge about any signs or symptoms of the disease has been the cause of such conditions.…”

Section: Introductionmentioning

confidence: 99%

“…9 Dr. Hasan Sadikin General Hospital's procedure for diagnosing ALL consists of anamnesis, physical and laboratory examination such as hematology indices, peripheral blood smear, and bone marrow examination. 5 Data on clinical and laboratory manifestation of ALL in children in Dr. Hasan Sadikin General Hospital Bandung is still unknown. Aim of this study was to give more information on clinical and laboratory manifestation of ALL in children in Dr. Hasan Sadikin General Hospital Bandung.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Laboratory Manifestation of Children with Acute Lymphoblastic Leukemia as an Assessment of Severity: A Study in Dr. Hasan Sadikin General Hospital

Angkasa

Suryawan

Prihatni

2019

amj

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Background: Acute lymphoblastic leukemia (ALL) is a disease caused by a mutation of lymphoid progenitor cells in bone marrow, that induces uncontrolled lymphoid cell proliferation. ALL is the most common type of leukemia in children. Various clinical and laboratory manifestation makes the diagnostic process more complicated. This study aimed to observe the clinical and laboratory manifestation of children with ALL in Dr. Hasan Sadikin General Hospital for diagnostic and assessment. Methods: The design of this study was a descriptive cross-sectional with a total sampling method. Data of all children under 18 years old with ALL diagnosed in 2015 to 2017 were included. The diagnosis of ALL was confirmed by examination of hematology indices, peripheral blood smear, and bone marrow aspiration classified by FAB. Inaccessible or incomplete medical records were excluded. Results: In total, 192 data of ALL patients were included. Most ALL patients predominantly occurred in boys (59.9%), and the age group of 1-5 years old (40.6%). The clinical manifestations were pallor (89.6%), hepatomegaly (79.7%) and fever (75%). Most patients experienced severe anemia with hemoglobin level <7g/dL (44.8%), leukocytosis >20.000 cells/mm3 (46.9%), severe thrombocytopenia with platelet count <20.000 cells/mm3 (51%), and blast cells count >50% (45.3%). Based on FAB classification, the majority of the patients were classified as ALL type L2 (65.6%). Conclusions: Clinical and laboratory manifestation of ALL patients can be used as a parameter for diagnostic and assessment of severity. Earlier diagnosis would result in better prognosis and more precise treatment for ALL patients.

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Hubungan Subtipe Sel Limfosit dengan Tingkat Remisi Pascakemoterapi Fase Induksi Leukemia Limfoblastik Akut

Cited by 4 publications

References 9 publications

The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis

The incidence and mortality of childhood acute lymphoblastic leukemia in Indonesia: A systematic review and meta-analysis

Karakteristik dan Jumlah Leukosit pada Anak Penderita Leukemia Limfoblastik Akut yang Menjalani Kemoterapi Fase Induksi di Rumah Sakit Al Islam Bandung

Clinical and Laboratory Manifestation of Children with Acute Lymphoblastic Leukemia as an Assessment of Severity: A Study in Dr. Hasan Sadikin General Hospital

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