Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome and BCR-ABL fusion oncogene. CML is one of the illnesses that may be treated using Tyrosine Kinase Inhibitors (TKIs), a type of targeted therapy. Since TKIs are the standard of therapy, long-term survival of CML has improved compared to chemotherapy and interferon-alpha. For the first-line treatment for CML, there are four commercially available TKIs that serve as an integral part of the disease management. However, there are many challenges in diagnosing, treating, and monitoring patients with chronic phase CML in Indonesia. This study highlights the epidemiology data of chronic phase CML patients, particularly at Dr. Cipto Mangunkusumo General Hospital, an Indonesian national referral hospital, and how to diagnose, select first-line TKIs, and monitor the response of treatment after TKIs administration.
Non-small cell lung cancer (NSCLC) biasanya terdeteksi pada pasien ketika sudah stadium lanjut dengan prognosis yang buruk. Seiring dengan perkembangan penelitian tentang epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors (TKIs) dan identifikasi mutasi EGFR, menjadi dasar munculnya targeted therapy pada kanker paru sehingga merubah hasil pencapaian pengobatan dan prognosisnya. Tulisan ini melaporkan sebuah kasus, pasien wanita berusia 37 tahun yang datang pertama kali dengan metastasis tulang yang disebabkan oleh adenokarsinoma paru EGFR mutasi positif yang menunjukkan respons pengobatan yang baik terhadap TKI.
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