“…The average diagnostic age in the US is 67 years, while in Europe, it is between 60 and 65 years [Deininger, 2021] [Hochhaus, 2017]. In Indonesia, China, Hong Kong, India, the Philippines, Singapore, South Korea, Thailand, and Malaysia, the average age is between 36 and 55 years, and the incidence is higher in men than women [Au, 2009], [Rajabto, 2022], [Kuan, 2018]. Overexpression of MCL-1 seen in several malignancies, including solid tumors and hematological malignancies, and it was the first to be discovered in leukemic cell lines myeloblastic humans in the early phase of differentiation [Pereira-Castro, 2022], [Senichkin, 2019], [Belmar, 2015], [Wei, 2020], and increased expression of this is associated with a poor prognosis [10].…”