Antiretroviral medication (ART) therapy is the primary method of managing HIV-positive patients. The primary factor leading to therapeutic failure is nonadherence to ART therapy. Personal traits (predisposition), availability to health information, and social support, can be linked to adherence throughout ART therapy. Through a review of the literature, we hope to learn more about how social support can improve People Living With HIV (PLHIV) patients’ compliance with ART treatment. The literature review method is employed in this research strategy. The search for articles turned up 14 articles from 2019 to 2023 that were relevant to the issue. Various sources can be used to provide social assistance. Social support from friends, family, and medical professionals has a significant impact on PLHIV compliance with taking ART. Peer Support Groups (KDS) play a function in preserving adherence to ART treatment in PLHIV in addition to family support. Peer support groups offer assistance in the form of knowledge about sickness and treatment as well as inspiration to continue taking antiretrovirals religiously in order to survive. Numerous journals demonstrate a link between different types of social support and medication adherence. There is something, nevertheless, that is inversely related to the study. Social support will, nevertheless, have a favorable effect on treatment adherence. It is impossible to increase social support from a single source. However, if it can work in concert with social support, it will be ideal. To get the best outcomes, namely treatment adherence to antiretroviral therapy, it is vital to develop positive relationships amongst sources of support. Medication adherence is also influenced by internal variables, such as knowledge and the desire to preserve health, in addition to external support factors.