Hubungan Pemberian Terapi Antipsikotik terhadap Kejadian Efek Samping Sindrom Ekstrapiramidal pada Pasien Rawat Jalan di Salah Satu Rumah Sakit di Bantul, Yogyakarta

Dania, Haafizah; Faridah, Imaniar Noor; Rahmah, Khansa F.; Abdulah, Rizky; Barliana, Melisa Intan; Perwitasari, Dyah Aryani

doi:10.15416/ijcp.2019.8.1.19

Cited by 4 publications

(4 citation statements)

References 11 publications

(11 reference statements)

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“…Table I reveals that the age group of 36-45 years dominated the research subjects. The findings of this research support the theory of another study, which claims that up to 90% of patients diagnosed with schizophrenia is between 15 and 55 years of age (Dania et al, 2019). Several studies have also found that schizophrenia patients are typically in their productive ages between 25 and 40 years of age (Mukaddas et al, 2014;Aryani & Sari, 2015;Yulianty et al, 2017).…”

Section: Agesupporting

confidence: 88%

Correlation between clozapine use and metabolic syndrome in schizophrenic patients

Harjaningsih,

Ikawati,

Mustofa

et al. 2023

Pharm Educ

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Background: Clozapine, an atypical antipsychotic agent, is effective for relapse or refractory schizophrenia that has failed to respond to other antipsychotic medications. Despite its effectiveness, clozapine has a higher risk of metabolic syndrome than other antipsychotics. Objective: This research aimed to identify the correlation between clozapine and metabolic syndrome, such as obesity, cholesterol, and blood glucose levels, in schizophrenic patients at Ghrasia Mental Hospital, Yogyakarta, Indonesia. Method: This is a cross-sectional research. Subjects who met the inclusion criteria were randomly sampled from outpatients between November 2021 and February 2022. The research collected medical record data (characteristic patients, medication patterns, and body mass index) and analysed blood profiles (cholesterol and glucose levels). The data were analysed descriptively and statistically. Result: Among the 71 patients in this research, 37 (52.11%) were male and 34 (47.89%) were female, with an average age of 36-45 years. The treatment patterns of patients were as follows: 44 were taking only clozapine and 27 patients did not use clozapine. Clozapine was frequently combined with risperidone and haloperidol in this research. Bivariate analysis using Fisher's Exact test revealed no significant correlation between clozapine use, clozapine regimen (single or combined), duration of clozapine therapy (>= 5 years), and clozapine dose (high or low) with obesity, hypercholesterolemia, and hyperglycemia. Meanwhile, multivariate analysis revealed a significant correlation between gender and obesity (p < 0.05), with women having a 0.299 higher risk than men. The effects of age and duration of schizophrenia on hypercholesterolemia and hyperglycemia were insignificant. Conclusion: There was no correlation found between clozapine use and metabolic syndrome. Gender was found to have a significant correlation with obesity in the research.

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Section: Agesupporting

confidence: 88%

Correlation between clozapine use and metabolic syndrome in schizophrenic patients

Harjaningsih,

Ikawati,

Mustofa

et al. 2023

Pharm Educ

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“…The dopamine D2 receptors are also found in the area of the region, the Basal Ganglia, which plays a role in motor movements. The blockade of D2 receptors in this area will cause extrapyramidal disorders such as Parkinsonism, Dyskinesia, tardive dyskinesia, etc (5,12).…”

Section: Discussionmentioning

confidence: 99%

Identification of Antipsychotic Side Effects with Glassgow Antipsychotic Side-Effect Scale (GASS)

Hasni

Putri

Anissa

2020

Jour. Health Sci Prev

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Schizophrenia is ranked 4th of the top 10 diseases that burden worldwide. If the population of Indonesia reaches 200 million, it estimates that around two million have Schizophrenia. Based on Data from the World Health Organization (WHO), it estimates that around 24 million people worldwide have schizophrenia.2 the American Psychiatric Association (APA) were reported the incidence of Schizophrenia in the United States is about 1% of the adult population with a total of more than 2 million people. Schizophrenic patients were treated by antipsychotic agents that act to inhibit dopamine receptors, especially D2, and also inhibit adrenergic acetylcholine receptors and serotonin 5-HT2A. It can manifest side effects like extrapyramidal syndrome, amenorrhea, drowsiness, and others. This research aims to the identification of antipsychotic side effects with Glasgow Antipsychotic Side-effect Scale (GASS). 100 schizophrenics in HB. Saanin Mental Hospital were participating in this descriptive study after fulfilling the criteria of inclusion and exclusion. This study used the GASS questionnaire to interview subjects who were signing informed consent and get an explanation about this study. In this study, 92% of subjects reported mild side effects. The frequent complaints were extrapyramidal effects, sedation and CNS effects, anticholinergic effects, and weight gain (93%,80%,70 0% and 70% respectively). We found women complained of the side effects more often (16.38 ± 5.275) than men (12.58 ± 5.484) significantly with the value P = 0.001. Gass instruments can use screening antipsychotic side effects. This study concludes the most side effects complaints being extrapyramidal and drowsiness, and women more commonly found side effects than men.

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“…Penderita skizofrenia di Indonesia adalah 0,3-1% dan biasanya timbul pada usia sekitar 18-45 tahun, namun ada juga yang baru berusia 11-12 tahun sudah menderita skizofrenia (Maryatun, 2015). Antipsikotik merupakan terapi utama pada skizofrenia, namun pemberian terapi ini terkadang dapat menimbulkan efek samping, salah satunya adalah sindrom ekstra piramidal yang dapat menyebabkan pasien enggan untuk minum obat secara rutin, akibatnya frekuensi kekambuhan menjadi meningkat (Dania et al, 2018). Sebuah penelitian yang dilakukan di salah satu Rumah Sakit Jiwa Pekan Baru menunjukkan terapi kombinasi antipsikotik lebih banyak digunakan (95,08%) dari pada terapi tunggal (4,96%).…”

Section: Pendahuluanunclassified

“…Hasil penelitian lainnya yang dilakukan pada salah satu Rumah Sakit di Bantul Jogjakarta menunjukkan penggunaan Antipsikotik atipikal yang menimbulkan gejala ekstra piramidal yang lebih rendah antara lain aripiprazol, quetiapin, dan klozapin. Pada pasien Forte Journal, Vol 02, No 02, Juli 2022 yang memperoleh terapi antipsikotik tunggal, sebanyak 5 orang mengalami efek samping sindrom ekstra piramidal, sedangkan pada pasien yang memperoleh terapi antipsikotik kombinasi, 7 orang mengalami efek samping sindrom ekstra piramidal (Dania et al, 2018).…”

Section: Pendahuluanunclassified

Gambaran Kejadian Ekstrapiramidal Sindrom Pada Pasien Terapi Antipsikotik Tipikal Di Rumah Sakit Jiwa Aceh

Asfianti

Syahfitri

Nst

2022

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The use of antipsychotics in schizophrenic patients often causes side effects in the form of Extra Pyramidal Syndrome (EPS), namely the presence of uncontrolled muscle movement disorders such as seizures, shaking and so on. The incidence of EPS is more common with the use of typical antipsychotics than atypicals. This study aims to see the incidence of EPS in inpatients with schizophrenia at the Aceh Mental Hospital located in Banda Aceh in 2020. The population in this study were all inpatients who were given typical antipsychotics. While the research sample was 399 samples collected from medical record data of inpatients in 2020, so the study was retrospective with a cross sectional approach. Data collected in the form of patient identity (gender, age), drug therapy (typical antipsychotics) and the incidence of EPS. The results showed that schizophrenic patients who received typical antipsychotic therapy who were hospitalized at the Aceh mental hospital in 2020, were 324 men (81.2%) and 75 women (18.8%), with the highest age range being at 36-45 years amounting to 202 people (50.6%). Typical antipsychotic therapy used in the form of combination of typical-typical and typical-atypical drugs, namely clozapine-trifluperazine (40.6%), chlorpromazine-risperidone (20.3%), haloperidol-chlorpromazine-trifluperazine (16%), haloperidolchlorpromazine (7%), and haloperidol-trifluperazine (5%). The incidence of EPS that occurred was 113 people (28.3%), with the highest number of EPS occurring from the administration of haloperidol-chlorpromazine-trifluperazine combination antipsychotic therapy, which was 61 people (15.3%).

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Hubungan Pemberian Terapi Antipsikotik terhadap Kejadian Efek Samping Sindrom Ekstrapiramidal pada Pasien Rawat Jalan di Salah Satu Rumah Sakit di Bantul, Yogyakarta

Cited by 4 publications

References 11 publications

Correlation between clozapine use and metabolic syndrome in schizophrenic patients

Correlation between clozapine use and metabolic syndrome in schizophrenic patients

Identification of Antipsychotic Side Effects with Glassgow Antipsychotic Side-Effect Scale (GASS)

Gambaran Kejadian Ekstrapiramidal Sindrom Pada Pasien Terapi Antipsikotik Tipikal Di Rumah Sakit Jiwa Aceh

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