HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. mexicana

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

“…dosage, the methanol had a higher response than the hexane and ethyl acetate extracts. 7 The antinociceptive activity of this species in an arthritic pain model involving 5-HT 1A receptors was demonstrated in other study. 15 Another study reports that the anxiolytic-like effects of a standardized fraction from inflorescences of T. americana is mediated by serotonergic receptors; the standardization was supported in the flavonoids contained: tiliroside, rutin, quercetin, a quercetin glucoside and kaempferol.…”

“…In previous studies, a significant dose-dependent anxiolytic-like activity was demonstrated for methanolic and aqueous extracts of Tilia inflorescences, further glycosides of quercetin and kaempferol were characterized and suggested as the main active compounds. 6,7 It is known that the quality and quantity of secondary metabolites particularly tend to fluctuate depending on factors such as genetic drift, physiological conditions, season, and harvesting time, as well as sample preparation and analytical method. [8][9][10] Numerous investigations on the aforementioned factors have been conducted; as a result, it has been found that the phenological stage and collection site strongly influence the quantity of secondary metabolites.…”

Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

“…Flavonoids of several classes are inhibitors of monoamine oxidase A or B, causing anti-depressants effects and also improving the conditions of Parkinson's patients (Ji & Zhang, 2006). Kaempferol showed an anxiolytic-like activity (Grundmann et al, 2009) and the anxiolytic activity of Tilia species had been attributed to the kaempferol 3-O-(6"-p-coumaroyl glucoside), also known as tiriloside (Aguirre-Hernandez et al, 2010).…”

Radical scavenging activity of extruded corn gruels with addition of linden inflorescence

“…is a widely used medicinal plant possessing several pharmacological effects due to the presence of active compounds [1][2][3][4]. Extracts and infusions from this plant have been applied in treatment of symptoms of common cold, bronchitis and cough.…”