HPLC method for the determination of fluvoxamine in human plasma and urine for application to pharmacokinetic studies

Automated analysis of fluvoxamine in rat plasma using a column‐switching system and ion‐pair high‐performance liquid chromatography

“…The precision in the present method is better (≤7.8%) than that of a study reported by Ulu (2007), in which the precision is within 11.29%. The extraction recovery rate is also higher (97%) than those in studies reported by Tournel et al (2001) and Saracino et al (2006), in which the rates were 92 and 94%, respectively.…”

“…The proposed column-switching system offers major advantages over earlier off-line methods (Palego et al, 2000;Ulu, 2007), because it eliminates tedious manual extraction and minimizes manipulation of the biological samples. The precision in the present method is better (≤7.8%) than that of a study reported by Ulu (2007), in which the precision is within 11.29%.…”

“…To date, several analytic methods have been developed for the determination of FLV in plasma: gas chromatography (Lacassie et al, 2000;Lamas et al, 2004), gas chromatography-mass spectrometry (Wille et al, 2005;Salgado-Petinal et al, 2005), high-performance liquid chromatography (HPLC) (Palego et al, 2000;Saracino et al, 2006;Ulu, 2007;Ertürk et al, 2005;Frahnert et al, 2003) and high-performance liquid chromatographymass spectrometry (Kirchherr and Kuhn-Velten, 2006;Shinozuka et al, 2006). All of these studies require pretreatment of plasma samples before analysis, as plasma is one of the most difficult biological matrices to analyze.…”

Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR

“…Two of them were the brand formulations from LILLY (Prozac ® ) and SOLVAY Pharma (Floxyfral ® ), the others were generic drugs from different countries. The declared amounts of the active ingredient in the various Table 1 Commercial formulations of fluoxetin (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and fluvoxamine (16)(17)(18)(19) All samples, as received, were stored in the dark at ambient temperature and humidity. They were all analysed within expiry dates.…”

Validated spectrophotometric method for the determination, spectroscopic characterization and thermal structural analysis of duloxetine with 1,2-naphthoquinone-4-sulphonate

“…NQS has been used as a chromogenic reagent for the spectrophotometric determination of primary and secondary amines [17][18][19][20][21][22][23][24]. According to the literature research, DH has been derivatized with NQS and determined using a UV visible spectrophotometric 1 The article is published in the original.…”