Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR

Trefi, Saleh; Gilard, Véronique; Balayssac, Stéphane; Malet‐Martino, Myriam; Martino, Robert

doi:10.1016/j.jpba.2007.11.038

Cited by 36 publications

(14 citation statements)

References 40 publications

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“…For example, qualitative identification and quantitation of fluoxetine ( 18 ) and fluvoxamine ( 19 ) in pharmaceutical formulations has been reported using 1D qFNMR and 2D 1 H-DOSY. 99 The 2D-DOSY experiment permitted the qualitative characterization of the active ingredients as well as excipients in the formulation. A study involving the application of 1D-qHNMR and 2D-DOSY in the analysis of extracts of Ligusticum porteri has also been reported.…”

Section: Two-dimensional Qhnmr Methodologymentioning

confidence: 99%

Quantitative ¹H NMR. Development and Potential of an Analytical Method: An Update

et al. 2012

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Covering the literature from mid-2004 until the end of 2011, this review continues a previous literature overview on quantitative 1 H NMR (qHNMR) methodology and its applications in the analysis of natural products. Among the foremost advantages of qHNMR is its accurate function with external calibration, the lack of any requirement for identical reference materials, a high precision and accuracy when properly validated, and an ability to quantitate multiple analytes simultaneously. As a result of the inclusion of over 170 new references, this updated review summarizes a wealth of detailed experiential evidence and newly developed methodology that supports qHNMR as a valuable and unbiased analytical tool for natural product and other areas of research.

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Section: Two-dimensional Qhnmr Methodologymentioning

confidence: 99%

Quantitative ¹H NMR. Development and Potential of an Analytical Method: An Update

et al. 2012

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“…Nearly every therapeutic category of drugs is available through the internet. Not only the performance and image-enhancing and “lifestyle drugs” [23,24], such as phosphodiesterase type 5 inhibitors [25-27] or anti-baldness products [28], but life-saving medicines (eg, from the World Health Organization Essential Medicines List), analgesics (nonsteroidal anti-inflammatory drugs, opioids) [29,30], psychiatric [31], obesity [32,33], and cardiologic drugs [18] can be purchased freely over the internet.…”

Section: Introductionmentioning

confidence: 99%

Consumers Turning to the Internet Pharmacy Market: Cross-Sectional Study on the Frequency and Attitudes of Hungarian Patients Purchasing Medications Online

Fittler¹,

Vida²,

Káplár³

et al. 2018

J Med Internet Res

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BackgroundDuring the past two decades, the internet has become an accepted way to purchase products and services. Buying medications online are no exception. Besides its benefits, several patient safety risks are linked to the purchase of medicines outside the traditional supply chain. Although thousands of internet pharmacies are accessible on the web, the actual size of the market is unknown. Currently, there is limited data available on the use of internet pharmacies, the number, and attitude of people obtaining medications and other health products from the internet.ObjectiveThis study aims to gather information on the frequency and attitudes of patients purchasing medications online in a nationally representative sample of outpatients. Attitudes towards main supply chain channels, perceived benefits, and disadvantages of influencing online medication purchase are evaluated.MethodsA cross-sectional explorative study using a personally administered survey was conducted in a representative sample of Hungarian outpatients in 2018.ResultsA total of 1055 outpatients completed the survey (response rate 77.23%). The mean age was 45 years, and 456 (43.22%) reported having chronic health conditions. The majority (872/1055, 82.65%) of the respondents were aware that medications could be obtained online, but only 44 (4.17%) used the internet for previous medication purchases. Attitudes towards the different pharmaceutical supply chain retail channels showed significant differences (P<.001), respondents accepted retail pharmacy units as the most appropriate source of medications while rejected internet pharmacies. Respondents were asked to evaluate 9 statements regarding the potential benefits and disadvantages about the online medicine purchase, and based on the computed relative attitude rate there is a weak still significant tendency toward rejection (P<.001). Correspondence of demographic factors, internet usage behavior, and prospective online drug purchase attitude was evaluated. Respondents who use the internet more and purchase goods online will be more likely to buy medications online. Furthermore, youth and education will determine the medication purchase behavior.ConclusionsMany patients will purchase medications on the internet in the future. Currently, there is an increased risk of patients buying products from illegal sites because these dominate the global online pharmacy market. Consequently, improved patient-provider communication and promotion campaigns are needed to inform the public about the safe use of internet pharmacies, as these initiatives can directly prevent patient safety threats.

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“…Electro-convulsive therapy, Psychotherapies and Cognitive behavior therapy are particularly effective for the most severe and resistant depressions 1 . Fluvoxamine is one of the antidepressants commonly used as first line treatment for major depressive disorders 2,3 SSRIs (selective serotonin reuptake inhibitor) are antidepressant drugs that increase serotoninergic neurotransmission via the selective inhibition of neuronal reuptake of serotonin 4,5 . Fluvoxamine is BCS class II drug which having low solubility and high permeability but it is practically soluble in ethanol, so it is suitable for formulating nanosuspension.…”

Section: Introductionmentioning

confidence: 99%

Inbuilt novel bioretardant feature of biopolymer isolated from cucumis sativa for designing drug loaded bionanosuspension

Tyagi

Madhav

2020

Journal of Drug Assessment

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Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR

Cited by 36 publications

References 40 publications

Quantitative ¹H NMR. Development and Potential of an Analytical Method: An Update

Quantitative ¹H NMR. Development and Potential of an Analytical Method: An Update

Consumers Turning to the Internet Pharmacy Market: Cross-Sectional Study on the Frequency and Attitudes of Hungarian Patients Purchasing Medications Online

Inbuilt novel bioretardant feature of biopolymer isolated from cucumis sativa for designing drug loaded bionanosuspension

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Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR

Cited by 36 publications

References 40 publications

Quantitative 1H NMR. Development and Potential of an Analytical Method: An Update

Quantitative 1H NMR. Development and Potential of an Analytical Method: An Update

Consumers Turning to the Internet Pharmacy Market: Cross-Sectional Study on the Frequency and Attitudes of Hungarian Patients Purchasing Medications Online

Inbuilt novel bioretardant feature of biopolymer isolated from cucumis sativa for designing drug loaded bionanosuspension

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Quantitative ¹H NMR. Development and Potential of an Analytical Method: An Update

Quantitative ¹H NMR. Development and Potential of an Analytical Method: An Update