2014
DOI: 10.1097/pas.0000000000000090
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HOXB13 G84E–related Familial Prostate Cancers

Abstract: Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk of prostate cancer, particularly early onset hereditary prostate cancer. The histomorphologic and molecular features of cancers arising in such carriers have not been studied. Here, we reviewed prostatectomy specimens from 23 HOXB13 G84E mutation carriers, mapping the total cancer burden by anatomically distinct cancer focus and evaluating morph… Show more

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Cited by 38 publications
(23 citation statements)
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“…Interestingly, in the three ERG + /SPINK1 + cases evaluated on whole sections by Flavin et al . and in the one observed in our recent series(12), only small areas of dual positivity were observed in otherwise ERG + /SPINK1 − foci. Such observations underscore the value of whole section-based studies, and, given the lack of a homogeneous ERG + /SPINK1 + tumor foci, these exceptions seem to prove the rule observed at the transcript level.…”
supporting
confidence: 61%
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“…Interestingly, in the three ERG + /SPINK1 + cases evaluated on whole sections by Flavin et al . and in the one observed in our recent series(12), only small areas of dual positivity were observed in otherwise ERG + /SPINK1 − foci. Such observations underscore the value of whole section-based studies, and, given the lack of a homogeneous ERG + /SPINK1 + tumor foci, these exceptions seem to prove the rule observed at the transcript level.…”
supporting
confidence: 61%
“…If ERG rearrangements occurred at any point in PCa development and progression, one would expect to observe with some frequency small pockets of nascent ERG + cancer arising within large ERG − tumor foci, which has never been reported. In contrast, we and others have published examples of apparent ERG + /ERG − , ERG + /ETV1 + and ERG + /SPOP mut cases which represent “collisions” of genetically distinct foci on whole section evaluation(4, 8, 11, 12). …”
mentioning
confidence: 71%
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“…Psödohiperplastik görünüm patolojik evreyi etkilemez [36]. HOXB13 G84E ile ilişkili ailevi prostat kanseri çok kez psödohi-perplastik özelliklere sahiptir [37].…”
Section: Asiner Adenokarsinom Varyantlarıunclassified
“…The human HOXB13 gene consists of two exons and three introns and encodes a 284 amino acid protein (NCBI: NP_006352.2) belonging to the homeobox gene family16. It encodes a transcription factor which plays a major role in normal prostate development1718.…”
mentioning
confidence: 99%