How Vitamin D Levels of Children Changed During COVID-19 Pandemic: A Comparison of Pre-pandemic and Pandemic Periods

Beyazgül, Güler; Bağ, Özlem; Yurtseven, İlkay; Coşkunol, Fulya; Başer, Saynur; Çiçek, Duygu; Kanberoğlu, Gül İrem; Dadaşer-Çelik, Filiz; Nalbantoğlu, Özlem; Özkan, Behzat

doi:10.4274/jcrpe.galenos.2022.2021-10-6

Cited by 17 publications

(17 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in a study by Michael et al, supplementation of vitamin D in adults and elders proved to decrease the risk of mechanical ventilation and clinical severity in COVID-19 [ 46 ]. This is important, as studies by Lee et al and Beyazgul et al concluded that during the pandemic, the vitamin D levels of children were lower than before the pandemic, especially in younger children [ 47 , 48 ]. In our study, vitamin D levels were lower in younger children as well.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Inflammatory Markers and Vitamin D Relationship in Pediatric Patients

Bagiu

Scurtu

Horhat

et al. 2022

Life

View full text Add to dashboard Cite

Background: Biomarkers play an important role in COVID-19, and more research in this regard is needed, especially in the case of children. This study aimed to look for a link between the C reactive protein (CRP), lactate dehydrogenase (LDH), creatine kinase (CK), vitamin D and COVID-19 in pediatric patients. Methods: This is a retrospective cohort study, performed on children diagnosed positively with COVID-19 at a children’s hospital in western Romania. Available CRP, LDH, CK vitamin D and clinical severity were recorded. For each biomarker, groups were formed by patients’ age. Mean/median group differences were assessed using Student’s t test or Mann–Whitney and Kruskal–Wallis with Dunn’s post hoc tests. Association was assessed using the chi2 test, while correlation was assessed using Spearman’s rank correlation. Results: 181 positive children were studied between 1 August 2021 and 1 February 2022. Average age was 8.76 years (SD = 3.93). There were 94 (51.93%) males and 87 (48.07%) females. The cases were: 62 asymptomatic (34.25%), 107 mild (59.12%), 9 moderate (4.97%), 3 severe (1.66%). Regarding CRP, a significant difference between older and younger patients was observed (p = 0.0034). Clinical severity was associated with CRP (p = 0.0281), LDH (p = 0.0410) and vitamin D (p = 0.0444). Regarding CK, no differences or associations proved significant. Correlation testing was conducted for CRP, LDH, vitamin D and clinical signs. With the exception of LDH-CRP and LDH-vitamin D, all relationships proved statistically significant. Conclusions: CRP, LDH and vitamin D levels are important biomarkers for COVID-19-positive pediatric patients, while CK was mostly within normal ranges.

show abstract

Section: Discussionmentioning

confidence: 99%

COVID-19 Inflammatory Markers and Vitamin D Relationship in Pediatric Patients

Bagiu

Scurtu

Horhat

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…The authors added that vitamin D deficiency may worsen the aggravation of pulmonary involvement by SARS-COV-2. Beyazgül et al 30 reported that school-aged children and adolescents had low 25 (OH) D levels during COVID-19 pandemic period due to the restriction rules applied to prevent COVID-19 spreads. Darren et al 31 was the first to study vitamin D status in pediatric multi-system inflammatory syndrome associated with SARS-CoV-2 (PIMS-TS).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

et al. 2022

View full text Add to dashboard Cite

Background Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility. Methods One hundred and eighty patients diagnosed to have COVID‐19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21–29 ng/mL, deficient at <20 ng/mL. Results Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency. Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96–4.9]; P = 0.002. The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95–8.55]; P < 0.001). Conclusions Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Impact Vitamin D deficiency could be a modifiable risk factor for COVID-19 in children and adolescents because of its immune-modulatory action. To our knowledge, ours is the first such study to investigate the VDR Fok I polymorphism in Caucasian children and adolescents with COVID-19. Vitamin D deficiency and the VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Clinical trials should be urgently conducted to test for causality and to evaluate the efficacy of vitamin D supplementation for prophylaxis and treatment of COVID-19 taking into account the VDR polymorphisms.

show abstract

“…During the pandemic, children's serum 25(OD)D concentration was significantly decreased. It was discussed that school closures and lockdowns were associated with this decrease ( 38 ). In the Turkey observational study for children under 18 years old, VD deficiency was significantly high in the COVID-19 patient group compared with the control group ( 39 ).…”

Section: “Mokusyoku Rule” and Food Educationmentioning

confidence: 99%

Lessons from the health policies for children during the pandemic in Japan

Shobako

2022

Front. Public Health

View full text Add to dashboard Cite

It is everyone's desire to seek the sound growth of children through food education and there is a critical need for fostering an environment for this purpose. Health policies are important for this support. To the present, the Japanese society has been greatly disrupted by COVID-19 pandemic. “Stay at home”, “mokusyoku (silent eating)”, and mask wearing were encouraged in nationwide campaigns as public health measures to combat COVID-19. There are some papers reporting negative effects of “stay at home” and lockdowns such as weight gain, decrease in physical activities and change in eating habits. In Japan, while benefits and advantages of food education during mealtime were previously well studied, the “mokusyoku” rule may directly run counter to this food education. Moreover, there are several reports showing that nutrients might contribute to prevention of infectious diseases. Japanese children were also encouraged to wear masks all day long. The results of the clinical research, especially randomized control trials, show limited protective effect of masks. On the other hand, negative outcomes of the masks were reported in various scenes. This review focuses on these topics and arousing reconsideration for a better environment for children.

show abstract

How Vitamin D Levels of Children Changed During COVID-19 Pandemic: A Comparison of Pre-pandemic and Pandemic Periods

Cited by 17 publications

References 30 publications

COVID-19 Inflammatory Markers and Vitamin D Relationship in Pediatric Patients

COVID-19 Inflammatory Markers and Vitamin D Relationship in Pediatric Patients

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

Lessons from the health policies for children during the pandemic in Japan

Contact Info

Product

Resources

About