How important are scaffolds and their surface properties in regenerative medicine

Idaszek, Joanna; Kijeńska, Ewa; Łojkowski, Maciej; Święszkowski, Wojciech

doi:10.1016/j.apsusc.2016.03.038

Cited by 51 publications

(27 citation statements)

References 57 publications

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“…Moreover, the associated microporosity allows a higher uptake. The hydrophilicity of scaffolds has a great influence on material performance in a biological environment, as demonstrated by Idaszek et al [35]. The more hydrophilic scaffolds, which have a higher contact area with the solution, suffered weight loss in a proportional rate to the absorbed amount of Tris solution.…”

Section: Degradation Testsmentioning

confidence: 99%

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Schardosim

Soulié

Poquillon

et al. 2017

Materials Science and Engineering: C

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This paper focuses on the fabrication of three-dimensional porous PLGA-biomimetic carbonated apatite composite scaffolds by freeze-casting and using dimethyl carbonate as a solvent. Several charge/polymer ratios were tested in order to finely understand the influence of the filler rate on the scaffold porosity and mechanical and degradation properties using complementary characterization techniques (SEM, mercury porosimetry and X-ray microtomography). It was demonstrated that the apatite ratio within the composite scaffold has a strong influence in terms of architecture, material cohesion, mechanical properties and in vitro degradation properties. An optimum biomimetic apatite ratio was reached to combine good mechanical properties (higher rigidity) and material cohesion. In vitro degradation studies showed that higher apatite filler rates limited PLGA degradation and enhanced the hydrophilicity of the scaffolds which is expected to improve the biological properties of the scaffolds in addition to the bioactivity related to the presence of the apatite analogous to bone mineral.

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Section: Degradation Testsmentioning

confidence: 99%

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Schardosim

Soulié

Poquillon

et al. 2017

Materials Science and Engineering: C

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“…Typically, three‐dimensional porous structures made from biomaterials such as polymers, ceramics, metals, or combinations of these, scaffolds, to be successful, must be able to promote cell attachment, proliferation and/or differentiation . Cell attachment and spreading on a biomaterial surface is a complex phenomenon, intermediated by extracellular matrix molecules that are absorbed at the surface of the biomaterial and strongly influenced by properties of the material surface, namely, its chemical composition, surface energy, polarity, wettability, roughness, and topography . For this reason, much attention has been dedicated to biomaterials surfaces, trying to understand how different surface properties modulate cell behavior, in one hand, and developing chemical and physical methods to modify biomaterials surfaces in order to optimize the biological response .…”

Section: Introductionmentioning

confidence: 99%

“…1 Cell attachment and spreading on a biomaterial surface is a complex phenomenon, intermediated by extracellular matrix molecules that are absorbed at the surface of the biomaterial and strongly influenced by properties of the material surface, namely, its chemical composition, surface energy, polarity, wettability, roughness, and topography. 2,3 For this reason, much attention has been dedicated to biomaterials surfaces, trying to understand how different surface properties modulate cell behavior, in one hand, and developing chemical and physical methods to modify biomaterials surfaces in order to optimize the biological response. [2][3][4][5][6][7] Wettability and surface energy, evaluated by contact angles measurements, are usually used to predict cell attachment to biomaterials' surface, although the correlation between these properties and cell behaviour is still subject of much discussion.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 For this reason, much attention has been dedicated to biomaterials surfaces, trying to understand how different surface properties modulate cell behavior, in one hand, and developing chemical and physical methods to modify biomaterials surfaces in order to optimize the biological response. [2][3][4][5][6][7] Wettability and surface energy, evaluated by contact angles measurements, are usually used to predict cell attachment to biomaterials' surface, although the correlation between these properties and cell behaviour is still subject of much discussion. 4,6,7 Inverse gas chromatography (IGC) is an appropriate tool to assess the surface properties of scaffolds, enabling the determination of a variety of parameters such as the dispersive component of the surface energy, specific interactions (nondispersive) with polar probes, Lewis acid-base character of the surface, surface nanoroughness parameter, and Flory-Huggins interaction parameter, among others.…”

Section: Introductionmentioning

confidence: 99%

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Surface characterization of polysaccharide scaffolds by inverse gas chromatography regarding application in tissue engineering

Coimbra

Coelho

Gamelas

2019

Surface & Interface Analysis

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Scaffolds are of paramount importance in tissue engineering, providing support for cell attachment and allowing proliferation or differentiation, and production of extracellular matrix. Their surface properties are of major interest since in great part, they determine the biological response to the scaffold. In the present work, three chitosan‐based polyelectrolytes scaffolds, namely, 1:1 chitosan‐alginate (Chit‐Alg), chitosan‐pectin (Chit‐Pect), and chitosan‐carboxymethyl cellulose (Chit‐CMC), were studied with regard to their surface properties by inverse gas chromatography. The dispersive component of the surface energy, a measure of the ability of a material to establish Lifshitz Van der Waals interactions, was 47.8 mJ·m−2 for Chit‐Alg, 36.9 mJ·m−2 for Chit‐Pect, and 38.5 mJ·m−2 for Chit‐CMC (at 40°C). All the scaffolds surfaces had an amphoteric character, however, with an apparent prevalence of Lewis acidity over the Lewis basicity. These results have been interpreted in terms of the influence of the different substituent groups in the polysaccharides backbone. The porosities of the Chit‐Alg, Chit‐Pect, and Chit‐CMC scaffolds, assessed by mercury intrusion porosimetry, were found to be of 98%, 96%, and 84%, respectively.

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“…Recently, fibers prepared through electrospinning have been widely applied in the biomedical field, including as tissue engineering scaffolds, as drug carriers, and in wound reparation. The great success of these materials is due to the combination of inorganic and organic components as raw materials and the similarity of their physical properties to those of the extracellular matrix, namely a large surface to volume ratio, a high porosity, and an interconnected pore structure [11] , [12] , [13] , [14] . Therefore, compared to other drug carriers, electrospun fibers can promote tissue regeneration [15] , [16] .…”

Section: Introductionmentioning

confidence: 99%

Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy

Lian

Meng

2017

Bioactive Materials

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Daunorubicin hydrochloride is a cell-cycle non-specific antitumor drug with a high therapeutic effect. The present study outlines the fabrication of daunorubicin hydrochloride-loaded poly (ε-caprolactone) (PCL) fibrous membranes by melt electrospinning for potential application in localized tumor therapy. The diameters of the drug-loaded fibers prepared with varying concentrations of daunorubicin hydrochloride (1, 5, and 10 wt%) were 2.48 ± 1.25, 2.51 ± 0.78, and 2.49 ± 1.58 μm, respectively. Fluorescence images indicated that the hydrophobic drug was dispersed in the hydrophilic PCL fibers in their aggregated state. The drug release profiles of the drug-loaded PCL melt electrospun fibrous membranes were approximately linear, with slow release rates and long-term release periods, and no observed burst release. The MTT assay was used to examine the cytotoxic effect of the released daunorubicin hydrochloride on HeLa and glioma cells (U87) in vitro. The inhibition ratios of HeLa and glioma cells following treatment with membranes prepared with 1, 5, and 10 wt% daunorubicin hydrochloride were 62.69%, 76.12%, and 85.07% and 62.50%, 77.27%, and 84.66%, respectively. Therefore, PCL melt electrospun fibrous membranes loaded with daunorubicin hydrochloride may be used in the local administration of oncotherapy.

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How important are scaffolds and their surface properties in regenerative medicine

Cited by 51 publications

References 57 publications

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Surface characterization of polysaccharide scaffolds by inverse gas chromatography regarding application in tissue engineering

Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy

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