Host biomarkers of clinical relevance in tuberculosis: review of gene and protein expression studies

John, Serene H.; Kenneth, John; Gandhe, Archana S.

doi:10.3109/1354750x.2011.628048

Cited by 28 publications

(24 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44 In a recent review, John et al suggested that lower IL-12 and higher IL-4 and IL-10 expression in both unstimulated and antigen-stimulated cultures should be promising to discriminate TB disease from LTBI. 12 As other studies, we did not replicate these observations. 45e48 Several factors may explain discrepancies between studies.…”

Section: Discussionsupporting

confidence: 37%

“…11 Multicytokine responses, more representative of the immune status of the host, might also identify cytokine profiles associated with latency, progression or dissemination. 12 Despite the critical need for improved diagnosis of TB in children and the poor knowledge of the mechanisms responsible for the greatest severity of TB infection during childhood, studies that simultaneously measured multiple chemokines and/or cytokines in pediatric infection are anecdotical. 13e15 The primary aim of this study was to explore cytokine/ chemokine responses to QFTB peptides in order to improve diagnosis and staging of M.tb infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytokine responses to quantiferon peptides in pediatric tuberculosis: A pilot study

Armand

Chhor

Lauzanne

et al. 2014

Journal of Infection

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 37%

Section: Introductionmentioning

confidence: 99%

Cytokine responses to quantiferon peptides in pediatric tuberculosis: A pilot study

Armand

Chhor

Lauzanne

et al. 2014

Journal of Infection

View full text Add to dashboard Cite

“…The levels of several cytokines, including interleukin-6 (IL-6), IL-10, IL-15, chemokine (C-X-C) motif ligand (CXCL)/interferon gamma-inducible protein 10 (IP-10), and monocyte chemoattractant protein 2 (MCP-2), were significantly higher in TB patients than in healthy controls (7,11,(18)(19)(20)(21); although these finding suggest important roles for these factors in disease pathogenesis, they are not sufficient for diagnosing Citation Jeong YH, Hur Y-G, Lee H, Kim S, Cho J-E, Chang J, Shin SJ, Lee H, Kang YA, Cho S-N, Ha S-J. 2015.…”

mentioning

confidence: 99%

“…The levels of several cytokines, including interleukin-6 (IL-6), IL-10, IL-15, chemokine (C-X-C) motif ligand (CXCL)/interferon gamma-inducible protein 10 (IP-10), and monocyte chemoattractant protein 2 (MCP-2), were significantly higher in TB patients than in healthy controls (7,11,(18)(19)(20)(21); although these finding suggest important roles for these factors in disease pathogenesis, they are not sufficient for diagnosing active as opposed to latent infections. Several studies have also suggested that biomarker combinations such as IFN-␥Ϫtumor necrosis factor alpha (TNF-␣), IFN-␥ϪIL-2, IFN-␥ϪIL-4, and IL-15ϪMCP-1 might be more sensitive than single markers (18,(22)(23)(24).…”

mentioning

confidence: 99%

“…However, PPD cross-reacts with nontuberculous mycobacteria as well as with Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine and has poor sensitivity in immunocompromised patients (6). The interferon gamma (IFN-␥) release assay (IGRA) has been widely used in clinical practice and public health policy for TB diagnosis (7). Commercial IGRAs such as the QuantiFERON-TB Gold In-Tube test (QFT-GIT) measure responses to M. tuberculosis-specific antigens, including early secretory antigenic target-6 (ESAT-6), culture filtrate protein 10 (CFP-10), and TB7.7 antigens, and discriminate between a M. tuberculosis infection and an immunity-induced response to BCG vaccination (8,9).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Discrimination between Active and Latent Tuberculosis Based on Ratio of Antigen-Specific to Mitogen-Induced IP-10 Production

et al. 2015

View full text Add to dashboard Cite

f Mycobacterium tuberculosis is the major causative agent of tuberculosis (TB). The gamma interferon (IFN-␥) release assay (IGRA) has been widely used to diagnose TB by testing cell-mediated immune responses but has no capacity for distinguishing between active TB and latent TB infection (LTBI). This study aims to identify a parameter that will help to discriminate active TB and LTBI. Whole-blood samples from 33 active TB patients, 20 individuals with LTBI, and 26 non-TB controls were applied to the commercial IFN-␥ release assay, QuantiFERON-TB Gold In-Tube, and plasma samples were analyzed for interleukin-2 (IL-2), IL-6, IL-8, IL-10, IL-13, tumor necrosis factor-alpha (TNF-␣), IFN-␥, monokine induced by IFN-␥ (MIG), interferon gamma inducible protein 10 (IP-10), interferon-inducible T cell alpha chemoattractant (I-TAC), and monocyte chemoattractant protein 1 (MCP-1) by using a commercial cytometric bead array. The Mycobacterium tuberculosis antigen-specific production of most of the assayed cytokines and chemokines was higher in the active TB than in the LTBI group. The mitogen-induced responses were lower in the active TB than in the LTBI group. When the ratio of TB-specific to mitogen-induced responses was calculated, IL-2, IL-6, IL-10, IL-13, TNF-␣, IFN-␥, MIG, and IP-10 were more useful in discriminating active TB from LTBI. In particular, most patients showed higher IP-10 production to Mycobacterium tuberculosis antigens than to mitogen at the individual level, and the ratio for IP-10 was the strongest indicator of active infection versus LTBI with 93.9% sensitivity and 90% specificity. In conclusion, the ratio of the TB-specific to the mitogen-induced IP-10 responses showed the most promising accuracy for discriminating active TB versus LTBI and should be further studied to determine whether it can serve as a biomarker that might help clinicians administer appropriate treatments. M ycobacterium tuberculosis, the major causative agent for tuberculosis (TB), is among the most successful human pathogens, infecting approximately 8.6 million people and leading to 1.3 million deaths each year (1). It is estimated that 2 billion people live with latent TB infection (LTBI) and are therefore a potential source of active TB (2, 3). Identifying LTBI is necessary in order to reduce the risk of development of the disease, while diagnosis of active TB can enable rapid treatment and disease control. To this end, diagnostic biomarkers that can accurately indicate disease status are needed (4, 5).There is presently no diagnostic gold standard for LTBI. Until recently, the tuberculin skin test (TST) involving the intracutaneous injection of purified protein derivative (PPD) into the forearm was the only available method for diagnosing LTBI. However, PPD cross-reacts with nontuberculous mycobacteria as well as with Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine and has poor sensitivity in immunocompromised patients (6). The interferon gamma (IFN-␥) release assay (IGRA) has been widely used in clinical practice a...

show abstract

Dissecting Tuberculosis Through Transcriptomic Studies

Rodrigues

Rosada

Malardo

et al. 2014

Transcriptomics in Health and Disease

View full text Add to dashboard Cite

Host biomarkers of clinical relevance in tuberculosis: review of gene and protein expression studies

Abstract: With this review we hope to provide a reliable guideline for biomarker studies in tuberculosis.

Cited by 28 publications

References 59 publications

Cytokine responses to quantiferon peptides in pediatric tuberculosis: A pilot study

Cytokine responses to quantiferon peptides in pediatric tuberculosis: A pilot study

Discrimination between Active and Latent Tuberculosis Based on Ratio of Antigen-Specific to Mitogen-Induced IP-10 Production

Dissecting Tuberculosis Through Transcriptomic Studies

Contact Info

Product

Resources

About