Hospital outcome of acute myocardial infarction in patients with and without diabetes mellitus

Otter, Wolfgang; Kleybrink, Sonja; Doering, W.; Standl, Eberhard; Schnell, Oliver

doi:10.1111/j.1464-5491.2004.01114.x

Cited by 63 publications

(44 citation statements)

References 29 publications

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“…The prognosis of diabetic patients with acute coronary syndrome is worsened by presence of other risk factors associated in metabolic syndrome, such as hypertension, obesity and dyslipidaemia (Zuanetti et al 1993;Behar et al 1997;Vaccaro et al 2004;Otter et al 2004;Howard et al 2006). The benefits of cardiac rehabilitation programs in patients with CAD both in programs with only aerobic exercise training (Oldridge et al 1988;O'Connor et al 1989;Yoshida et al 2001;Taylor et al 2004Taylor et al , 2006 and in those with resistance or combined aerobicresistance exercise (Stewart et al 1998;Adams et al 1999;Jancik et al 2003;Izawa et al 2004;Vincent and Vincent 2006) have been repeatedly reported.…”

Section: The Exercise Programmentioning

confidence: 99%

Benefit of Combined Cardiac Rehabilitation on Exercise Capacity and Cardiovascular Parameters in Patients with Type 2 Diabetes

Svačinová

Novàkovâ

Placheta

et al. 2008

Tohoku J. Exp. Med.

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Favorable effects of exercise training on cardiovascular prognosis have been reported repeatedly in patients with diabetes mellitus type 2 (DM2). However, little is known about the cardiovascular rehabilitation effects in diabetic patients with coronary artery disease (CAD). This study has evaluated the benefits of combined aerobic-resistance training in two groups of patients -diabetics and non-diabetics -after percutaneous coronary intervention (PCI). Changes in exercise capacity parameters, resting cardiovascular and anthropometrical parameters were evaluated in 77 patients who completed 12-weeks of combined aerobic-resistance training: 32 patients with DM2 (DM) and 45 patients without DM2 (NDM). Significant improvements in exercise capacity (total peak workload [W peak ], peak workload per kg of body weight [W peak /kg], total peak oxygen uptake [V O 2peak ], peak oxygen uptake per kg of body weight [V O 2peak /kg]) were found in both DM and NDM ( p < 0.01 and p < 0.001, respectively). The decrease in resting heart rate (HR rest ), resting systolic (SBP rest ) resting diastolic (DBP rest ) blood pressures, body weight (BW) and BMI in the DM group was not statistically significant. However, there was a statistically significant decrease in SBP rest , BW and BMI in the NDM group. In conclusion, this study demonstrated similar beneficial effects of combined cardiovascular training on exercise capacity in patients with or without type 2 diabetes mellitus. Our results suggest that the combined cardiac training is well tolerated and useful in secondary prevention in patients with DM2 and CAD. type 2 diabetes mellitus; cardiac rehabilitation; aerobic-resistance training; exercise capacity. Coronary artery disease (CAD) in patients with type 2 diabetes mellitus (DM2) is the major cause of mortality and morbidity (Donahue and Orchard 1992;Haffner et al. 1998;Laakso 1999;Hu et al. 2005) in Western countries. These patients have 2 to 4 times higher risk of cardiovascular diseases as compared with individuals without diabetes mellitus. Moreover, the progno-

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Section: The Exercise Programmentioning

confidence: 99%

Benefit of Combined Cardiac Rehabilitation on Exercise Capacity and Cardiovascular Parameters in Patients with Type 2 Diabetes

Svačinová

Novàkovâ

Placheta

et al. 2008

Tohoku J. Exp. Med.

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“…In our own experience, the MS prevalence is similar in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes (T2DM; 44% and 56%, respectively) [8]. The strong association between glucose and CV risk is also supported by the prognostic value of a random blood glucose measurement in the occasion of acute coronary syndrome [9].…”

Section: Introductionmentioning

confidence: 57%

Blood Glucose Control and Coronary Heart Disease

Bianchi

Penno

Miccoli

et al. 2010

Herz

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Epidemiologic data support the hypothesis of a direct and independent relationship between hyperglycemia and cardiovascular disease. The lack of a clear-cut threshold value in diabetic patients, and the persistence of the relationship in nondiabetic population as well, suggest that glycemia is a continuous variable, similarly to other cardiovascular risk factors. Moreover, increased plasma glucose levels contribute to cardiovascular risk by activating multiple atherogenic mechanisms. In spite of evident plausibility for hyperglycemia as a cardiovascular risk factor per se, intervention data remain controversial. Results of recent large-scale intervention trials, such as ACCORD, ADVANCE, and VADT, seem to undermine the concept that tight glycemic control confers some protection against cardiovascular disease in patients with type 2 diabetes, while maintenance of near-normal glycemic control from earlier stage of the disease and during acute coronary events seems to be more beneficial. However, individualized therapies remain the cornerstone of strategies aimed to reduce cardiovascular risk associated to hyperglycemia.

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“…Der Nutzen der Infusion mit Glucose und Humaninsulin im intensivmedizinischen Umfeld könnte auch partiell durch eine Optimierung der Herznervenfunktion in der Akutphase bedingt sein [2,23]. Die häufi-ge autonome Dysfunktion bei Diabetikern mit akutem Myokardinfarkt, die in einer erhöhten Ruhefrequenz und selteneren Angabe pektanginöser Beschwerden deutlich wird, unterstreicht die Notwendigkeit einer Optimierung der autonomen Funktion während der intensivmedizinischen Betreuung [22].…”

Section: Diskussionunclassified

Neu initiierte Insulintherapie und kardiale autonome Funktion bei Typ-2-Diabetes

Schnell

Kilinc

Rambeck

et al. 2004

Herz

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Hospital outcome of acute myocardial infarction in patients with and without diabetes mellitus

Cited by 63 publications

References 29 publications

Benefit of Combined Cardiac Rehabilitation on Exercise Capacity and Cardiovascular Parameters in Patients with Type 2 Diabetes

Benefit of Combined Cardiac Rehabilitation on Exercise Capacity and Cardiovascular Parameters in Patients with Type 2 Diabetes

Blood Glucose Control and Coronary Heart Disease

Neu initiierte Insulintherapie und kardiale autonome Funktion bei Typ-2-Diabetes

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