Neu initiierte Insulintherapie und kardiale autonome Funktion bei Typ-2-Diabetes

Schnell, Oliver; Kilinc, Sonja; Rambeck, Aurel; Standl, Eberhard

doi:10.1007/s00059-004-2612-2

Cited by 6 publications

(4 citation statements)

References 21 publications

(31 reference statements)

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“…Schnell et al . 8 have reported that 4 months’ insulin therapy significantly shortened QTc in parallel with decreased HbA1c. The results are consistent with the finding of the present study that QTc was shortened following multiple daily insulin injections.…”

Section: Discussionmentioning

confidence: 98%

“…Two previous studies have evaluated changes in QTc in patients with T2D receiving insulin therapy, but these studies have not examined the correlation between the change in QTc and glycemic parameters. Schnell et al 8 have reported that 4 months' insulin therapy significantly shortened QTc in parallel with decreased HbA1c. The results are consistent with the finding of the present study that QTc was shortened following multiple daily insulin injections.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Takebayashi et al 7 reported that patients with T2D who were initiated on insulin therapy showed significantly increased QT interval in parallel with glycated hemoglobin (HbA1c) reduction after 3 months. In contrast, Schnell et al 8 reported that 4 months of insulin therapy could shorten QT intervals in patients with T2D.…”

Section: Introductionmentioning

confidence: 90%

“…In contrast, Schnell et al . 8 reported that 4 months of insulin therapy could shorten QT intervals in patients with T2D.…”

Section: Introductionmentioning

confidence: 99%

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Multiple daily insulin injections ameliorate QT interval by lowering blood glucose levels in patients with type 2 diabetes

Kobayashi

Nagao

Izumi

et al. 2021

Therapeutic Advances in Endocrinology

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Background: A prolonged QT interval plays a causal role in fatal arrhythmia and is known to be a risk factor for sudden cardiac death. Although diabetic patients with microvascular complications tend to have a longer QT interval, the therapeutic effect of diabetes on the QT interval remains unclear. Here, we assessed the changes in QT interval in patients with type 2 diabetes (T2D) who received multiple daily insulin injections. Materials and methods: Patients with T2D ( n = 34) who were admitted to our hospital and initiated multiple daily insulin injections for glycemic control were enrolled in this study. Clinical measurements, including electrocardiogram, were taken on admission and discharge. The QT interval was measured manually in lead II on the electrocardiogram, and corrected QT interval (QTc) was calculated using Bazett’s formula. The change in QTc (ΔQTc) during hospitalization (median, 15 days) and clinical parameters affecting ΔQTc were investigated. Results: QTc was shortened from 439 ± 24 to 427 ± 26 ms during hospitalization ( p < 0.0001). ΔQTc was positively correlated with the changes in fasting plasma glucose (ΔFPG, r = 0.55, p = 0.0008) and glycated albumin ( r = 0.38, p = 0.026) following insulin therapy, but not with the final dose of insulin ( r = −0.20, p = 0.26). The multiple regression analyses revealed that ΔFPG was independently associated with ΔQTc. Conclusions: Multiple daily insulin injections can ameliorate QT interval by lowering the blood glucose levels in T2D, suggesting that glycemic control is important for preventing patients with T2D from sudden cardiac death.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

“…In contrast, Schnell et al . 8 reported that 4 months of insulin therapy could shorten QT intervals in patients with T2D.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multiple daily insulin injections ameliorate QT interval by lowering blood glucose levels in patients with type 2 diabetes

Kobayashi

Nagao

Izumi

et al. 2021

Therapeutic Advances in Endocrinology

View full text Add to dashboard Cite

show abstract

Heart Rate Variability in Diabetes Patients

et al. 2006

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Diabetes mellitus can cause cardiovascular autonomic neuropathy and is associated with increased cardiovascular deaths. We investigated cardiovascular autonomic neuropathy in diabetics and healthy controls by analysis of heart rate variability. Thirty-one diabetics and 30 age-and sexmatched controls were included. In the time domain we measured the mean R -R interval (NN), the standard deviation of the R -R interval index (SDNN), the standard deviation of the 5-min R -R interval mean (SDANN), the root mean square of successive R -R interval differences (RMSSD) and the percentage of beats with a consecutive R -R interval difference > 50 ms (pNN50). In the frequency domain we measured high-frequency power (HF), low-frequency power (LF) and the LF/HF ratio. Diabetes patients had lower values for time-domain and frequency-domain parameters than controls. Most heart rate variability parameters were lower in diabetes patients with chronic complications than in those without chronic complications.

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Neuropatia autonômica cardiovascular diabética: fatores de risco, impacto clínico e diagnóstico precoce

Rolim

Sá

Chacra

et al. 2008

Arq. Bras. Cardiol.

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Cardiovascular autonomic neuropathy (CAN) is one of the most clinically significant complications of diabetes mellitus (DM), but one of the least frequently diagnosed. In this review, we discuss the major risk factors for the development and progression of CAN in patients with DM, the natural history of autonomic neuropathy and its impact on cardiovascular disease in DM, as well as the tests for the early diagnosis and staging of CAN in the clinical practice. The bibliographic research was based on two databases: Medline and Tripdatabase, with the following descriptors: diabetic cardiovascular autonomic neuropathy and cardiovascular autonomic neuropathy and diabetes. We selected English and German articles, written between 1998 and 2007. In its initial stages (early and intermediate), CAN may be diagnosed and reversed. However, in advanced cases (severe stage), the only treatment that remains is a symptomatic one. CAN is associated with higher cardiovascular morbidity and mortality rates and poor quality of life in diabetic individuals.

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Neu initiierte Insulintherapie und kardiale autonome Funktion bei Typ-2-Diabetes

Abstract: The study demonstrates that insulin therapy with regular insulin optimizes cardiac autonomic function in type 2 diabetes mellitus. It emphasizes the value of cardiac reflex tests with regard to follow-up of cardiac autonomic function in diabetes.

Cited by 6 publications

References 21 publications

Multiple daily insulin injections ameliorate QT interval by lowering blood glucose levels in patients with type 2 diabetes

Multiple daily insulin injections ameliorate QT interval by lowering blood glucose levels in patients with type 2 diabetes

Heart Rate Variability in Diabetes Patients

Neuropatia autonômica cardiovascular diabética: fatores de risco, impacto clínico e diagnóstico precoce

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