Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β

Abstract

Human placental extract and animal-derived placental extracts from pigs and horses host a wide range of biological activities. Several placental products are used as medicines, cosmetics, and healthcare substances worldwide. However, the use of placental extracts for neuronal functioning is currently not established because the number of relevant studies is limited. A few previous reports suggested the neuroprotective effect and dendrite genesis effect of placental extract. However, no studies have reported on neurogenesis in placental extracts. Therefore, we aimed to investigate the effects of horse placental extract on neurogenesis, and we examined the protective effect of the extract on the onset of memory disorder. A horse placental extract, JBP-F-02, was used in this study. JBP-F-02 treatment dose-dependently increased the number of neural stem cells and dendrite length under Aβ treatment in primary cultured cortical cells. The oral administration of JBP-F-02 to a 5XFAD mouse model of Alzheimer’s disease at a young age significantly prevented the onset of memory dysfunction. This study suggests that the extract has the potential to prevent dementia.

Equine placental extract supplement as a night barking remedy in dogs with cognitive dysfunction syndrome

“…This suggests that eqPE administration may be effective for anxiety-induced night barking and its influence may be mediated through the central nervous system. This finding is consistent with the hypothesis that placental extract prevents hippocampal atrophy in menopausal model mice and ameliorates cognitive function in chronic restraint stress in ovariectomised mice model with Alzheimer's disease, and older mice (de Toledo, et al, 2021;Kogure & Tohda, 2017;Takuma et al, 2012;Yamauchi et al, 2019). Moreover, the influence was observed within a relatively short period of 1 week after the eqPE administration indicating that it has a fast onset of effect.…”

“…Moreover, its effect on the hippocampus of aged mice may be mediated via the upregulation of Early growth response protein 1 ( Egr1 ), Growth Arrest and DNA‐Damage‐Inducible, Beta ( GADD45b ), NGFI‐A Binding Protein 2 ( NAB2 ), and Vascular Endothelial Growth Factor A ( VEGF‐A ) genes (Yamauchi et al., 2019). Moreover, we found that eqPE prevented the onset of memory dysfunction in 5XFAD mice, a model of Alzheimer's disease, and elevated neurogenesis and dendrite density after Aβ treatment (de Toledo, et al., 2021). Thus, our speculation is supported by the aforementioned reports.…”

“…Several studies have indicated that placental extracts contribute to improved cognitive function. Placental extracts have been shown to suppress hippocampal atrophy in menopausal mice model and improve cognitive function in model mice with Alzheimer's disease (de Toledo, et al., 2021; Kogure & Tohda, 2017; Takuma et al., 2012). Porcine placental extract ameliorated the age‐associated decrease in memory function in mice.…”

“…Recently, we received consultations for three cases in which the owners were severely sleep‐deprived and their quality of life was worsened by their senior dogs with CDS frequently barking at night. Placental extracts have been reported to improve cognitive function in an Alzheimer's disease mouse model (de Toledo, et al., 2021; Kogure & Tohda, 2017) and aged mice (Yamauchi et al., 2019). Herein, we describe the administration of equine placental extract (eqPE) as a pet supplement to improve the cognitive function of these three dogs and the corresponding changes in their night barking.…”

“…Placental extracts have been reported to improve cognitive function in an Alzheimer's disease mouse model (de Toledo, et al, 2021;Kogure & Tohda, 2017) and aged mice (Yamauchi et al, 2019). Herein, we describe the administration of equine placental extract (eqPE) as a pet supplement to improve the cognitive function of these three dogs and the corresponding changes in their night barking.…”