Hormone Replacement Therapy in the Geriatric Patient: Current State of the Evidence and Questions for the Future. Estrogen, Progesterone, Testosterone, and Thyroid Hormone Augmentation in Geriatric Clinical Practice: Part 1

Schwartz, Erika; Holtorf, Kent

doi:10.1016/j.cger.2011.07.013

Cited by 11 publications

(8 citation statements)

References 159 publications

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“…Cellular processes that have been proposed to explain aging-induced sarcopenia include changes in hormone levels [2], inflammation-initiated impairment in protein synthesis and acceleration of protein degradation in muscle [3], responses to accumulated reactive oxygen species [4] and alterations in factors that regulate myogenesis [5]. We found evidence that cellular sense-cence also contributes to the processes of the sarcopenia of aging.…”

Section: Introductionmentioning

confidence: 74%

MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

Klein

Mitch

et al. 2014

Aging

123

101

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The mechanisms underlying the development of aging-induced muscle atrophy are unclear. By microRNA array and individual qPCR analyses, we found significant up-regulation of miR-29 in muscles of aged rodents vs. results in young. With aging, p85α, IGF-1 and B-myb muscle levels were lower while the expression of certain cell arrest proteins (p53, p16 and pRB) increased. When miR-29 was expressed in muscle progenitor cells (MPC), their proliferation was impaired while SA-βgal expression increased signifying the development of senescence. Impaired MPC proliferation resulted from interactions between miR-29 and the 3'-UTR of p85a, IGF-1 and B-myb, suppressing the translation of these mediators of myoblast proliferation. In vivo, electroporation of miR-29 into muscles of young mice suppressed the proliferation and increased levels of cellular arrest proteins, recapitulating aging-induced responses in muscle. A potential stimulus of miR-29 expression is Wnt-3a since we found that exogenous Wnt-3a stimulated miR-29 expression 2.7-fold in primary cultures of MPCs. Thus, aging-induced muscle senescence results from activation of miR-29 by Wnt-3a leading to suppressed expression of several signaling proteins (p85α, IGF-1 and B-myb) that act coordinately to impair the proliferation of MPCs contributing to muscle atrophy. The increase in miR-29 provides a potential mechanism for aging-induced sarcopenia.

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Section: Introductionmentioning

confidence: 74%

MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

Klein

Mitch

et al. 2014

Aging

123

101

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“…Testosterone improves the efficacy of germ cell differentiation and active maturation [33,34]. Recently, testosterone has been used in the clinical treatment of andropause patients with oligozoospermia and maturation arrest of sperms, despite its various side effects [10,11,35,36]. Hence, consistent with previous studies, it can be suggested that the enhanced activity and health of Leydig cells together with the enhanced serum testosterone levels by CRS-10 were the bases of improved spermatogenesis and activation of sperm.…”

Section: Discussionmentioning

confidence: 99%

Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male

Noh

Kim

et al. 2012

Nutr Res Pract

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Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was measured based on typical physiological stress. After daily intake of CRS-10 for 4 weeks, the level of testosterone, physical activity and both the number and activity of sperm in older rats (18 weeks) were measured. Furthermore, thirty males were surveyed with AMS (Aging Males' Symptoms) questionnaire after intake of 400 mg of CRS-10. Overall, CRS-10 protected TM3 cells from serum restriction and oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in rats were significantly enhanced. In addition, physical locomotion was markedly improved. Daily intake of 400 mg of CRS-10 improved the quality of life among agingmale respondents, according to a clinical survey using the AMS. The results indicate the potential of CRS-10 as a safe and efficacious natural substance for reducing or alleviating andropause symptoms.

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“…7 Some scientific literature showed that using supplementation containing hormones such as estrogen, progesterone, testosterone, growth hormone, and thyroid hormones have the potential to improve the quality of life and prevents many symptoms and conditions associated with aging, including fatigue, depression, weight gain, weakness, osteoporosis, loss of libido, and cardiovascular disease. 8 There are doubts about the side effects of long term use of hormonal therapy, including increased potential risk of cancer. When trying to find the idea of a balance for each patient, the doctor should be concerned not only about increasing their lifetime, but also their health, including the length of time a person experiences a high quality, strong, and happy life.…”

Section: Hormonal Therapy On Aging Process In Womenmentioning

confidence: 99%

“…When trying to find the idea of a balance for each patient, the doctor should be concerned not only about increasing their lifetime, but also their health, including the length of time a person experiences a high quality, strong, and happy life. 8 Because levels of hormones decline because of aging, hormone treatment has been referred to as "fountain of youth (youth peak)". Many studies were conducted to prove the efficacy of hormonal therapy, but the data has not shown the expected positive impact of hormones on aging (Table 1).…”

Section: Hormonal Therapy On Aging Process In Womenmentioning

confidence: 99%

Hormonal therapy for aging process in women

Siregar

2015

Int J Adv Med

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The aging process is a natural process that continues overtime. This process begins with fertilization and commonly experienced by all living things, with different manifestation between each person. The process of birth, growth, puberty and being old are part of the normal aging process, with death as the end result. 1 Turner et al. stated that the aging process is divided into external and internal aging. External aging process is a process with visible symptoms. Alteration can be observed from the skin, hair, teeth, and posture. Internal aging is aging process which was not visible, such as degenerative changes that occur in the body. These changes occur in the nervous system, cardiovascular, respiratory, digestive, urinary, and immune system. Aging process may be caused by age factor and may also occur due to psychosocial factors such as stress, socioeconomic, environmental, food (nutrition) and individual health. 2 Re-epitheliazation of the stratum corneum after blistering is also diminished , being twice as long for people over 75 than for those aged 25. 3-5 Injury repair also diminishes with age. Wound healing even begin later is proceed more slowly. For examples a wound area of 40 cm 2 , which in 20 years old subjects took 40 days to heal,required almost twice as long 70 days in those over 80. 4,5

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Hormone Replacement Therapy in the Geriatric Patient: Current State of the Evidence and Questions for the Future. Estrogen, Progesterone, Testosterone, and Thyroid Hormone Augmentation in Geriatric Clinical Practice: Part 1

Cited by 11 publications

References 159 publications

MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male

Hormonal therapy for aging process in women

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