2014
DOI: 10.18632/aging.100643
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Abstract: The mechanisms underlying the development of aging-induced muscle atrophy are unclear. By microRNA array and individual qPCR analyses, we found significant up-regulation of miR-29 in muscles of aged rodents vs. results in young. With aging, p85α, IGF-1 and B-myb muscle levels were lower while the expression of certain cell arrest proteins (p53, p16 and pRB) increased. When miR-29 was expressed in muscle progenitor cells (MPC), their proliferation was impaired while SA-βgal expression increased signifying the d… Show more

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Cited by 107 publications
(102 citation statements)
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References 55 publications
(102 reference statements)
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“…13 Recent studies have indicated that Wnt signaling also plays an important role in skeletal muscle atrophy and regeneration. 14,22 In this study, we have demonstrated that both Wnt signaling and FoxO signaling are activated in skeletal muscle of DCM mice. We have also shown that Wnt signaling promotes FoxO1 nuclear translocation without affecting its phosphorylation level and increases the expression of FoxO target genes in cultured skeletal muscle cells.…”
Section: Discussionmentioning
confidence: 64%
See 1 more Smart Citation
“…13 Recent studies have indicated that Wnt signaling also plays an important role in skeletal muscle atrophy and regeneration. 14,22 In this study, we have demonstrated that both Wnt signaling and FoxO signaling are activated in skeletal muscle of DCM mice. We have also shown that Wnt signaling promotes FoxO1 nuclear translocation without affecting its phosphorylation level and increases the expression of FoxO target genes in cultured skeletal muscle cells.…”
Section: Discussionmentioning
confidence: 64%
“…22 We found that the expression of a Wnt/β-catenin/TCF/LEF target gene Axin2 and the nuclear amount of β-catenin were increased in the skeletal muscle of DCM mice ( Figure 2C and 2D), suggesting that Wnt signaling as well as FoxO signaling is activated in the skeletal muscle of DCM mice. …”
Section: Foxo Signaling and Wnt Signaling Are Both Activated In Skelementioning
confidence: 87%
“…Altered miRNA expression and disruption of miRNA biogenesis through deletion of the enzyme Dicer, (expression of which declines with age,) can also shift cells into a senescent state (Mori et al, 2012). miRNAs such as miR-29 have been discovered to be master regulators of CS (Hu et al, 2014) and it is possible that individual CS phenotypes such as SASP may also be regulated by specific miRNAs. In C. elegans and Drosophila perturbed miRNA expression can alter lifespan, modulate lipofuscin accumulation in tissues, accelerate a transcriptional profile associated with aging and reduce age-related neurodegeneration (Boehm and Slack, 2005; Liu et al, 2012).…”
Section: Hallmarks Of Cellular Senescencementioning
confidence: 99%
“…Indeed, aging is not just cell cycle arrest. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] In analogy, although cell cycle progression is important in carcinogenesis, we do not define cancer as cell cycle progression. For one, intestinal and bone marrow progenitor cells proliferate faster than tumor cells.…”
Section: Introductionmentioning
confidence: 99%