2014
DOI: 10.1007/s10522-014-9532-1
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Abstract: The term cellular senescence was introduced more than five decades ago to describe the state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes associated with cellular senescence have expanded beyond growth arrest to include alterations in cellular metabolism, secreted cytokines, epigenetic regulation and protein expression. Recently, senescence has been shown to play an important role in vivo not only in relation to aging, but also during embryonic development. Thus, cellu… Show more

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Cited by 100 publications
(68 citation statements)
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“…Recent evidence suggests that cellular senescence is a potential contributor to the age-related inflammation observed in the brain through the secretion of SASP factors and/or by abrogating neurogenesis during adulthood. Microglia undergo telomere shortening with aging and microglia-mediated up-regulation of SASP components is associated with normal brain aging and age-related NDs (Chinta et al, 2013; Chinta et al, 2015; Tan et al, 2014). Senescent-like phenotypes have also been observed in Purkinje, cortical and hippocampal neurons in response to DNA damage (Tan et al, 2014).…”
Section: Considerations On Functional Consequences Of Genomic Instmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent evidence suggests that cellular senescence is a potential contributor to the age-related inflammation observed in the brain through the secretion of SASP factors and/or by abrogating neurogenesis during adulthood. Microglia undergo telomere shortening with aging and microglia-mediated up-regulation of SASP components is associated with normal brain aging and age-related NDs (Chinta et al, 2013; Chinta et al, 2015; Tan et al, 2014). Senescent-like phenotypes have also been observed in Purkinje, cortical and hippocampal neurons in response to DNA damage (Tan et al, 2014).…”
Section: Considerations On Functional Consequences Of Genomic Instmentioning
confidence: 99%
“…Microglia undergo telomere shortening with aging and microglia-mediated up-regulation of SASP components is associated with normal brain aging and age-related NDs (Chinta et al, 2013; Chinta et al, 2015; Tan et al, 2014). Senescent-like phenotypes have also been observed in Purkinje, cortical and hippocampal neurons in response to DNA damage (Tan et al, 2014). Expression of both p16 and SASP metallopeptidase MMP3 were increased in astrocytes from aged and AD autopsied human brain tissues relative to young healthy controls, and higher amounts of p16 and γ-H2AX positive cells were also observed in PD samples.…”
Section: Considerations On Functional Consequences Of Genomic Instmentioning
confidence: 99%
“…In a recent article in Cell Reports , Chinta and colleagues have shown that astrocytes exhibiting an age‐associated (senescent) phenotype are toxic to neurons in vitro, and their removal is associated with better outcomes in a mouse model of PD. This finding may be relevant to other neurodegenerative conditions, such as Alzheimer's and amyotrophic lateral sclerosis, in which cellular senescence is also implicated …”
mentioning
confidence: 71%
“…It is not only restricted to the reduced replicative ability, but associated with changes in cellular metabolism, epigenetic regulation and gene expression [40]. In brain, neurons senescence might be implicated with several age-related neurodegenerative diseases [41]. A recent study suggested that cellular senescence can contribute to increased viral replication.…”
Section: Discussionmentioning
confidence: 99%