Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male

Noh, Young; Kim, Do Hee; Kim, Joon Yub; Park, Jiae; Kim, Ok Hyeon; Han, Dongil; Kim, Won Yong; Kim, Sung Su; Lee, Moo Yeol; Heo, Seok Hyun; Kim, Misook; Lee, Won Bok; Jeong, Yoonhwa; Myung, Soon Chul

doi:10.4162/nrp.2012.6.6.505

Cited by 28 publications

(19 citation statements)

References 34 publications

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“…Recently, Noh et al . () noticed a significant increase in serum testosterone in ageing rats (18 week‐old) after treatment with a mixture of rooibos and dandelion extract. However, it was not investigated which of these plants was responsible for the increase.…”

Section: Discussionmentioning

confidence: 99%

In vivoeffects ofAspalathus linearis(rooibos) on male rat reproductive functions

Opuwari

Monsees

2013

Andrologia

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Aspalathus linearis (rooibos tea) may improve sperm function owing to its antioxidant properties. To test this hypothesis, male rats were given 2% or 5% rooibos tea for 52 days. No significant alterations were observed in body and reproductive organs weight, serum antioxidant capacity and testosterone level. Seminiferous tubules displayed complete spermatogenesis. However, a significant (P < 0.05) decrease in tubule diameter and germinal epithelial height was observed. Epithelial height of caput epididymides showed a significant increase. Unfermented rooibos significantly enhanced sperm concentration, viability and motility. Fermented rooibos also significantly improved sperm vitality (P < 0.01), but caused a significant increase in spontaneous acrosome reaction (P < 0.05), whereas unfermented did not. Creatinine was significantly enhanced in all treated rats, consistent with significant higher kidney weights. Rooibos significantly reduced alanine transaminase level, while 2% fermented rooibos significantly decreased aspartate transaminase level (P < 0.01). In conclusion, treatment with rooibos improved sperm concentration, viability and motility, which might be attributed to its high level of antioxidants. However, prolonged exposure of rooibos might result in subtle structural changes in the male reproductive system and may induce acrosome reaction, which can impair fertility. Intake of large amounts of rooibos may also harm liver and kidney function.

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Section: Discussionmentioning

confidence: 99%

In vivoeffects ofAspalathus linearis(rooibos) on male rat reproductive functions

Opuwari

Monsees

2013

Andrologia

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“…Treatment with dandelion extract (50 µg/mL) increased the cell viability (Noh et al. 2012 ), and further studies are required to establish the potential of this extract for alleviating symptoms of andropause. However, no study has reported the steroidogenic effects of TOE in Leydig cells in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…These effects may be attributed to protection and activation of Leydig cells and the production of endogenous testosterone (Noh et al. 2012 ). The mechanism underlying the steroidogenic effect of T. officinale extract (TOE) in mouse Leydig cells has not been studied thus far.…”

Section: Introductionmentioning

confidence: 99%

Steroidogenic effects ofTaraxacum officinaleextract on the levels of steroidogenic enzymes in mouse Leydig cells

Chung

Noh

Kim

et al. 2018

Animal Cells and Systems

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In this study, we investigated the steroidogenic effect of Taraxacum officinale extract on mouse TM3 Leydig cells, which produce male hormones by increasing the levels of steroidogenic enzymes. Steroidogenic enzymes are involved in the production of testosterone in the testis. To date, the steroidogenic effect of T. officinale has not been reported. Therefore, we examined the steroidogenic effects of T. officinale extract (TOE) on mouse Leydig cells in vitro. Traditionally, plants have been used for the treatment of various kinds of ailments. For many years, some medicinal plants have been used to regulate steroidogenesis or late-onset hypogonadism (LOH). In particular, plants belonging to the genus Taraxacum have anti-inflammatory, anti-nociceptive, anti-oxidant, and anti-cancer properties. In this study, we determined whether the TOE exerts steroidogenic effects by increasing the levels of enzymes associated with steroidogenesis, such as the steroidogenic acute regulatory protein (STAR), CYP11A1, and translocator protein (TSPO) in the mitochondria and CYP17A1 in the smooth endoplasmic reticulum, in mouse Leydig cells. Our results showed that the TOE significantly increased the mRNA and protein levels of steroidogenic enzymes, thereby increasing the testosterone levels in mouse Leydig cells. Thus, our results indicate that the TOE increases the levels of steroidogenic enzymes, and further studies are required to establish the potential of this plant in regulating steroidogenesis and improving LOH.

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“…The study by Eweoya, Oyewopo, and Yama () designed at examining the possible impact of the leaf extract of G. brevis on male fertility in adult male rats. Glyphaea brevis is thought to be medicinally useful; its traditional use in reproductive remedies has been reported: these effects may be attributed to protection and activation of Leydig cells and the production of endogenous testosterone (Noh et al, ). The mechanism underlying this effect of Glyphaea brevis twigs extract (GBT) in TM3 Leydig cells has not been studied thus far.…”

Section: Introductionmentioning

confidence: 99%

Effect ofGlyphaea brevistwigs extract on cell viability, apoptosis induction and mitochondrial membrane potential in TM3 Leydig cells

et al. 2019

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Glyphaea brevis twigs (Spreng) Monach. (GBT) are used by local herb healers to manage male sexual fertility disorders. The aim of this study was to examine the effects of G. brevis twigs on TM3 Leydig cells. GBT was extracted using methanol solvent, and Leydig cells were exposed to the respective concentrations of GBT extract (0.1, 1, 10, 100 and 1,000 μg/ml) for 24 and 72 hr respectively. Parameters evaluated include cell morphology, viability (MTT assay), mitochondrial membrane potential (TMRE dye), apoptosis (Annexin V Alexa Fluor 488 binding) and RT‐qPCR analyses of the mRNA expression. Results revealed that GBT had no cytotoxic effect on cell viability and the cell morphology. GBT also revealed a considerable elevation (p < 0.05) in fluorescence intensity, accompanied by intact mitochondria in TM3 Leydig cells. Furthermore, GBT resulted in the reduction of necrotic and apoptotic cells. The mRNA StAR was upregulated markedly with the effect prominent at 100 μg/ml. This study showed that GBT might be useful for managing male infertility ailments.

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Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male

Cited by 28 publications

References 34 publications

In vivoeffects ofAspalathus linearis(rooibos) on male rat reproductive functions

In vivoeffects ofAspalathus linearis(rooibos) on male rat reproductive functions

Steroidogenic effects ofTaraxacum officinaleextract on the levels of steroidogenic enzymes in mouse Leydig cells

Effect ofGlyphaea brevistwigs extract on cell viability, apoptosis induction and mitochondrial membrane potential in TM3 Leydig cells

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