<i>In vivo</i>effects of<i>Aspalathus linearis</i>(rooibos) on male rat reproductive functions

Opuwari, Chinyerum Sylvia; Monsees, Thomas K.

doi:10.1111/and.12158

Cited by 33 publications

(49 citation statements)

References 49 publications

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“…Sixty‐three‐day‐old sexually mature inexperienced male Wistar rats weighing between 200 and 250 g were randomly assigned to three groups as follows: Group 1 received tap water and served as control ( n = 6); Group 2 received 2% black tea ( n = 6); and Group 3 received 5% black tea ( n = 6). Each group received its treatment regimen ad libitum as the only means of drinking fluid for 52 days (Marnewick et al, 2009; Opuwari & Monsees, 2014). The fluid intake and body weights of the animals were, respectively, noted on a daily and weekly basis.…”

Section: Methodsmentioning

confidence: 99%

“…Following a 52-day treatment with 2% and 5% black tea, the motility of rat spermatozoa from the right epididymis was assessed using the swim-out technique described by Mdhluli and van der Horst (2002) and Opuwari and Monsees (2014). Spermatozoa (3 µl) collected from were determined by the computer-assisted semen analyzer (CASA) (Microptic).…”

Section: Sperm Motilitymentioning

confidence: 99%

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In vivo effects of black tea on the male rat reproductive system and functions of the kidney and liver

Opuwari

Monsees

2020

Andrologia

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This study focused on the effects of black tea on the male reproductive system as well as the kidney and liver functions. Male Wistar rats were given aqueous extract of black tea (2% and 5%) for 52 days as the only means of drinking fluid, while control rats received tap water. Black tea enhanced sperm vitality (44%–49%), total sperm motility (10%–12%) and acrosome reaction (2%–9%) (p < .05). Body weight gain, testis, epididymis, seminal vesicles, prostate, liver weight, testosterone level, sperm concentration, ferric reducing antioxidant power (FRAP) and antioxidant levels in the testes, liver and kidney remained unchanged (p > .05). Black tea (5%) increased kidney weight (p < .05). Testis and epididymis showed normal histological appearance. However, black tea significantly reduced the diameter (9%–10%) and epithelial height (9%–10%) of the seminiferous tubule, but increased the epithelial height of the cauda epididymis (8%–24%) (p < .05). A significant reduction in serum levels of alanine aminotransaminase (ALT) (38%) and aspartate aminotransaminase (AST) (23%–34%) was observed (p < .05); creatinine level, on the other hand, increased (8%–72%) (p < .05). Black tea improved several sperm parameters, but may cause subtle changes in certain reproductive organs and the kidney functions.

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Section: Methodsmentioning

confidence: 99%

Section: Sperm Motilitymentioning

confidence: 99%

In vivo effects of black tea on the male rat reproductive system and functions of the kidney and liver

Opuwari

Monsees

2020

Andrologia

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“…Furthermore, it is also known that gonadotropins act on the hypothalamic–gonadal–pituitary axis. On the other hand, one of the primary causes of male infertility is the sudden disruption in the hormone regulation of testicular cells (Opuwari & Monsees, ) the major role of LH molecule is to attach directly to specific receptors of the Leydig cells and cause the release of androgens. In this study, there was a significant ( p < 0.5) increase of LH in rats treated at dose of 400 mg/ kg.…”

Section: Discussionmentioning

confidence: 99%

“…Today, it is known that infertility is a major reproductive health problem affecting 10%–15% or 60–80 million of couples worldwide (Vyas & Raval, ). One of the most important origin of male infertility results from decrease is the sperm quality (sperm production, sperm motility, sperm viability and sperm morphology) (Opuwari & Monsees, ), alteration of formation of sperm cells (Parks, Lee, Huang, & Kaproth, ) and hormonal disorder (Arikawe, Oyerinde, Olatunji‐Bello, & Obika, ; Sharma & Agarwal, ). The ageing process in men encompasses slow progressive and instable modifications in sexual steroid levels, with a decrease in serum testosterone of approximately 1% per year after the age of 30 (Fernandes, ) and the quality of spermatozoa related to increase reactive oxygen species produced with ageing.…”

Section: Introductionmentioning

confidence: 99%

Sperm parameters quality and reproductive effects of methanolic extract ofAlchornea cordifolialeaves on senescent male rats

et al. 2019

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The effect of the methanolic extract of Alchornea cordifolia leaves on the fertility of senescent male rats was assessed in this study. 40 rats received daily distilled water, testosterone, 200 and 400 mg/kg of extract of Alchornea cordifolia. The reproductive organs weight, the gonadotropins, testosterone and cholesterol level, the sperm parameters, histology of the testes and epididymis were assessed. The weight of testes and prostate (400 mg/kg) significantly increased (p < 0.05) as well as the level of FHS (p < 0.001), LH and testosterone (p < 0.01) at a dose of 400 mg/kg, respectively, while the cholesterol decreased at a dose of 200 mg/kg (p < 0.05) and 400 mg/kg (p < 0.01) respectively. The testes and epididymis were full of spermatozoa particularly at a dose of 400 mg/kg. The sperm count and morphology significantly increased at both doses of 200 mg/kg (p < 0.01; p < 0.001) and 400 mg/kg (p < 0.001; p < 0.01) respectively. The sperm motion (PROG, VAP, VSL, VCL) (p < 0.001), (ALH, BCF) (p < 0.05) increased at a dose of 200 mg/kg and decreased at a dose of 400 mg/ kg. The overall results provide the strong evidence of the fertility potential of the methanolic extract of Alchornea cordifolia leaves in senescent male rats.

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“…Fresh preparations were made every day and administered to the experimental rats ad libitum (Opuwari and Monsees 2014).…”

Section: Rooibos Tea Preparationmentioning

confidence: 99%

Long‑term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats

Akinrinmade¹,

Omoruyi²,

Dietrich³

et al. 2017

Acta Neurobiologiae Experimentalis

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Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats. FRHT was administered to the animals ad libitum for 7 weeks prior to the induction of ischemic injury via a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. Our results showed that long-term consumption of FRHT by Wistar rats significantly reduced brain oedema and neuronal apoptosis, but did not attenuate BBB damage following cerebral ischemia. Analysis of whole-brain homogenates showed significantly reduced lipid peroxidation levels, increased total antioxidant capacity and resulted in improved neurobehavioural outcomes in FRHT-treated rats when compared with untreated animals. Taken together, our results tend to suggest that continuous consumption of FRHT could confer some protection against ischemic brain injury (IBI) and is therefore highly recommended for patients with stroke-predisposing conditions.

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In vivoeffects ofAspalathus linearis(rooibos) on male rat reproductive functions

Cited by 33 publications

References 49 publications

In vivo effects of black tea on the male rat reproductive system and functions of the kidney and liver

In vivo effects of black tea on the male rat reproductive system and functions of the kidney and liver

Sperm parameters quality and reproductive effects of methanolic extract ofAlchornea cordifolialeaves on senescent male rats

Long‑term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats

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