Sperm parameters quality and reproductive effects of methanolic extract of<i>Alchornea cordifolia</i>leaves on senescent male rats

Njila, Marie Ide Ngaha; Lembè, Dieudonné Massoma; Landry, Koloko Brice; Meng, Goh Yong; Ebrahimi, Mahdi; Awad, Elmutaz Atta; Baiee, Falah; Kenmogne, Hubert; Hambe, Magloire; Mandenguè, Samuel Honoré

doi:10.1111/and.13359

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…The Ghrelin receptor was found mostly in Leydig cells and to a lesser amount in Sertoli cells, confirming GRE function in spermatogenesis regulation. Furthermore, research have revealed that GRE delays the beginning of puberty in male rats and modulates the proliferation of Leydig cells (10). Chronic Ghrelin treatment improves the antioxidant defense mechanism in the rat testis by increasing GPx activity and lowering MDA levels, according to evidence (30).…”

Section: Discussionmentioning

confidence: 99%

“…Ghrelin suppressed mRNA expression of the gene encoding stem cell factor (SCF), a critical signal for germ cell generation and a possible regulator of Leydig cell development, in adult rats (5). Chronic Ghrelin therapy improves the antioxidant defense mechanism in the rat testis by increasing glutathione peroxidase activity (GPX) and lowering malondialdehyde (MDA) levels (10). In this study we evaluated the effect of Ghrelin on sperm analysis and the antioxidant system.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Ghrelin on Epididymal Sperm Analysis and Antioxidant System in Hyperthyroidic Adult Male Rats

Hamza¹,

AL-Saeed²

2022

Basrah J. Vet. Res.

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The study's objective is to evaluate the enhanced effect of Ghrelin (GRE) on sperm analysis and the antioxidant system in male rats after inducing hyperthyroidism by L-thyroxin. The rats (50 males) were split into five groups. The first group consisted of 10 male rats that were given normal saline for 30 days S.C and set as a control group. While the second group (positive group) was 10 male rats with hyperthyroidism were given normal saline for 30 days S.C, the third group was 10 male rats with hyperthyroidism were given Ghrelin at a dose of (0.5nmol/100μl saline) for 30 days S.C, and the fourth group was male 10 rats with hyperthyroidism were given Ghrelin (1nmol/100μl saline) for 30 days S.C. The fifth group consisted of 10 hyperthyroid male rats that were given Ghrelin at a dose of (2nmol/100μl saline) for 30 days S.C. The results show a significant (P≤0.05) decrease in all parameters of sperm analysis, the number of births and antioxidative system in hyperthyroid group compared to control group. While, all treated groups with GRE (0.5, 1 and 2 nmol) shows enhance effect in sperm analysis, the number of births and antioxidant system compared to the hyperthyroid group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Ghrelin on Epididymal Sperm Analysis and Antioxidant System in Hyperthyroidic Adult Male Rats

Hamza¹,

AL-Saeed²

2022

Basrah J. Vet. Res.

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“…Using a surgical microscissor, the left caudal epididymis was submerged in 2 ml of phosphate-buffered saline and sliced into roughly 200 pieces to liberate the spermatozoa from the epididymal tubules measured (Ngaha Njila et al, 2019). The epididymal semen suspension was right away kept at 37°C for future investigation.…”

Section: Evaluation Of Sperm Qualitymentioning

confidence: 99%

The Impact of Clinacanthus nutans (Burm. F.) Leaf Extract on Sperm Quality and Antioxidant Activity in Male Mice Induced with Streptozotocin

Abdulwahid-Kurdi

2024

JBRA

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Objective: Clinacanthus nutans (C. nutans) is a medicinal herb that most people with diabetes have historically taken. It's a diet high in antioxidants, which are supposed to help people live longer and be healthier.It is the first study to suggest using C. nutans to enhance the quality of sperm in male mice given a streptozotocin (STZ) injection.Methods: Sixty mice were divided into two groups at the age of four weeks: group one was fed a regular diet (n=10), while group two was administered a high-fat diet (n=50) for eight weeks to develop obesity. Obese mice were given 100mg/kg of STZ to produce hyperglycemia with a 20% mortality rate. Then, 40 hyperglycemic mice were separated into two groups: STZ (n=10) and sample (n=30). The treatment groups were administered a methanolic extract of C. nutans leaves by gavage at doses of 150, 300, and 500mg/kg of body weight (n=10) for 4 weeks.Results: In contrast to the STZ group, there was a substantial (p=0.001) drop in serum blood glucose and total sperm abnormalities in mice at varying doses. Catalase, glutathione s-transferase (GST), and total antioxidant capacity significantly (p=0.001) increased in the STZ mice group at varying doses, but malondialdehyde was reduced. In comparison to STZ mice, testosterone and luteinizing hormone (LH) levels improved in mice treated with extracts of C. nutans at various doses. For all of the following dependent variables, extraction of the leaf at higher concentrations of 500 milligrams/kilogram has better efficacy than 300 and 150 mg/kg after 4 weeks of treatment.Conclusions: The research and development of new natural agents to combat oxidative stress-related diseases have sparked a lot of interest. As a result, the potential leaf extract of C. nutans contains anti-hyperglycemic compounds and improves the quality of sperm in male mice.

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“…Alchornea cordifolia leaves remain effective in the treatment of male fertility problems. Studies conducted by Ajibade and Olayemi (2015) and Ngaha-Njila et al (2019) have shown that the methanoic extract of Alchornea cordifolia leaves improves male fertility and sperm quality, respectively. Nevertheless, few studies have been done with the aqueous extract.…”

Section: Introductionmentioning

confidence: 99%

Effect of an Aqueous Extract of Alchornea Cordifolia (Euphorbiacea) Leaves on Sperm Parameters and Reproductive Function of Male Wistar Rats

Koné

Goueh²,

Daouda

et al. 2021

ESJ

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Alchornea cordifolia (euphorbiaceae) is a tree whose leaves are used in traditional medicine to cure several health problems. Little information, however, exist on the effects of this herb on the male reproductive system. In order to assess the effect of Alchornea cordifolia on reproductive male parameters and testosterone production, twenty-four male wistar rats divided into four groups of six rats were used. The aqualus extract of Alchornea cordifolia was administered at a dose of 100 mg/kg of bw, 200 mg/kg of bw, and 400 mg/kg of bw per day, orally for 60 days. A significant increase in androgen-dependent organs, testosterone quantity, mobility, and sperm concentration was observed at doses of 200 mg/kg of bw and 400 mg/kg of bw. Only the unwinger sperm count significantly increased at the 100 mg/kg of bw dose. These results revealed that the aqualius extract of the leaves of Alchornea cordifolia has the potential to improve sperm quality and have positive effects on the reproductive system.

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Sperm parameters quality and reproductive effects of methanolic extract ofAlchornea cordifolialeaves on senescent male rats

Cited by 11 publications

References 26 publications

Effect of Ghrelin on Epididymal Sperm Analysis and Antioxidant System in Hyperthyroidic Adult Male Rats

Effect of Ghrelin on Epididymal Sperm Analysis and Antioxidant System in Hyperthyroidic Adult Male Rats

The Impact of Clinacanthus nutans (Burm. F.) Leaf Extract on Sperm Quality and Antioxidant Activity in Male Mice Induced with Streptozotocin

Effect of an Aqueous Extract of Alchornea Cordifolia (Euphorbiacea) Leaves on Sperm Parameters and Reproductive Function of Male Wistar Rats

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