Hormone replacement in survivors of childhood cancer and brain tumors: safety and controversies

Abstract

Childhood cancer survivors are at risk for developing endocrine disorders, including deficits in growth hormone, thyroid hormone and sex hormones. The influence these hormones have on cell growth and metabolism has raised concerns regarding the safety of their use as treatments in survivors of childhood cancer and brain tumors. This manuscript offers a summary of current knowledge, controversies and areas for future research pertaining to this area.

Evolving approaches in paediatric thyroid cytopathology: A review

“…Additionally, surgical complications from thyroidectomy, such as recurrent laryngeal nerve injury and hypoparathyroidism, are more common in children 28 . Finally, thyroidectomy often leads to the need for lifelong supplementation of thyroid hormone, which requires relatively close follow‐up in a growing child as opposed to a stable‐weight adult 29,30 . Given the differences in clinical presentation and long‐term outcome between adults and children with thyroid nodules and thyroid malignancy, care needs to be taken in the utilisation of adult guidelines in the paediatric setting.…”