Hormonal responses to fighting in hamsters: Separation of physical and psychological causes

Huhman, Kim L.; Moore, Timothy O.; Mougey, Edward H.; Meyerhoff, James L.

doi:10.1016/0031-9384(92)90097-l

Cited by 70 publications

(29 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such subjects are afraid of any other male, even males that are not aggressive (Huhman et al, 1991(Huhman et al, , 1992Potegal et al, 1993). Interactions in our experiments were quite brief and apparently less stressful.…”

Section: Discussionmentioning

confidence: 73%

“…Previous studies that used the conditioned defeat model have shown that cortisol concentrations were elevated immediately after defeat in both acutely and chronically defeated hamsters (Huhman et al, 1991(Huhman et al, , 1992Kollack-Walker et al, 1997;Jasnow et al, 2001). In our experiment, 1 d after the exposure condition and 1 h after the Y-maze tests, no difference was found between the three groups (eight subjects per group) in levels of either cortisol or testosterone.…”

Section: No Differences In Cortisol and Testosterone Concentrationmentioning

confidence: 99%

See 1 more Smart Citation

Recognition of Familiar Individuals in Golden Hamsters: A New Method and Functional Neuroanatomy

Lai¹,

Ramiro²,

Yu³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

The ability to recognize individuals is essential for many aspects of social interaction and social organization, yet we know relatively little about the neural mechanisms underlying this ability. Most laboratory studies of individual recognition in rodents have studied differential responses to familiar versus unfamiliar individuals rather than differential responses to equally well known individuals having different significance for the subject. In experiment 1, we use a new method for studying true individual recognition in which male hamsters first had different experiences with two stimulus males (exposures to one male across a wire-mesh barrier and fights with another male). One day later, losers of fights were tested in a Y-maze for reactions to one of the two familiar males. Subjects tested with the familiar winner avoided this stimulus male, but subjects tested with the familiar, neutral male were attracted to him. Immunohistochemistry for c-Fos and Egr-1 implicate several areas of the brain in individual recognition, particularly the anterior piriform cortex, the CA1 and CA3 regions of anterior dorsal hippocampus, anterior and posterior dentate gyrus, and perirhinal cortex. In experiment 2, temporary inactivation of the CA1 region of anterior dorsal hippocampus by microinfusion of lidocaine eliminated the avoidance of the familiar winner, but a saline control injection had no effect. These results are the first to use a rodent model to characterize neural circuits involved in the recognition of equally well known individuals and the corresponding emotional responses to them.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: No Differences In Cortisol and Testosterone Concentrationmentioning

confidence: 99%

Recognition of Familiar Individuals in Golden Hamsters: A New Method and Functional Neuroanatomy

Lai¹,

Ramiro²,

Yu³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Repeated brief defeats by a larger, aggressive resident produce defensive and submissive behaviors, even in response to a smaller, non-aggressive male, a phenomenon known as conditioned defeat (CD). Animals that have been defeated display an activated HPA axis, as indicated by increased ACTH, â-endorphin, cortisol and corticosterone release, while dominant animals do not (80)(81)(82). In addition, data suggest that CD results in a wide range of physiological, behavioral and autonomic changes in the defeated animal, including increased anxiety, and a host of other changes that are reminiscent of CRH-and stress-induced effects (90).…”

Section: Elevated Plus Maze (Epm)mentioning

confidence: 99%

The Pharmacology of CP‐154,526, a Non‐Peptide Antagonist of the CRH1 Receptor: A Review

2003

View full text Add to dashboard Cite

Since CRH has been shown to mediate stress-induced physiological and behavioral changes, it has been hypothesized that CRH receptor antagonists may have therapeutic potential in disorders that involve excessive CRH activity. CP-154,526 and its close analog antalarmin are potent, brain-penetrable, selective nonpeptide CRH1 receptor antagonists that were discovered in an effort to develop compounds with efficacy in CNS disorders precipitated by stress. Since its discovery many investigators have used CP-154,526 as a tool to study the pharmacology of CRH and its receptors and to evaluate its therapeutic potential in a variety of CNS and peripheral disorders. Systemically-administered CP-154,526 has been demonstrated to antagonize CRH-and stress-induced neuroendocrine, neurochemical, electrophysiological, and behavioral effects.These findings support the hypothesis that CRH1 receptor antagonists may have therapeutic utility in a number of neuropsychiatric disorders. CP-154,526, as well as other CRH1 receptor antagonists that have since been discovered, have also shown activity in several preclinical models of anxiety, depression, and substance abuse, while having little effect on locomotor activity and motor function. Although these effects are on occasion inconsistent among different laboratories, clinical evaluation of CRH1 antagonists appears justified on the basis of these and clinical data implicating the involvement of CRH in several CNS disorders. The effects of CRH1 antagonists on cognition, neurodegeneration, inflammation, and the gastrointestinal system have not been as extensively characterized and additional studies will be necessary to evaluate their therapeutic potential in these areas.

show abstract

“…For example, social defeat in male golden hamsters activates the HPA axis causing an acute increase in plasma levels of ACTH and cortisol [Huhman et al, 1991]. Males that are repeatedly defeated also have elevated basal cortisol levels and decreased testosterone levels [Huhman, et al, 1992]. Repeated social subjugation during adulthood causes a complete inhibition of offensive aggression, along with increased submission and avoidance [Huhman et al, 1991[Huhman et al, , 1992[Huhman et al, , 2003Potegal et al, 1993;Jasnow et al, 1999].…”

Section: The Biobehavioral Effects Of Stress Are Age Dependentmentioning

confidence: 99%

Stress, Aggression, and Puberty: Neuroendocrine Correlates of the Development of Agonistic Behavior in Golden Hamsters

Wommack

Delville²

2007

Brain Behav Evol

View full text Add to dashboard Cite

During puberty, agonistic behaviors undergo significant transitions. In golden hamsters, puberty is marked by a transition from play fighting to adult aggression. During early puberty, male golden hamsters perform play-fighting attacks. This response type is gradually replaced by adult attacks over the course of puberty. Interestingly, this behavioral transition does not appear to be controlled by changes in gonadal steroids. Instead, the shift from play fighting to adult aggression in male golden hamsters is driven by pubertal changes in glucocorticoid levels. Specifically, the transition from play fighting to adult aggression coincides with developmental increases in glucocorticoid levels, and external manipulations such as social stress or treatment with corticosteroid receptor agonists accelerate this behavioral shift. Moreover, the consequences of social stress differ greatly between juvenile and adult male golden hamsters. Although a single defeat during adulthood causes severe and long lasting behavioral and neuroendocrine consequences, socially subjugated juveniles show only transient behavioral effects. As such, it is likely that pubertal changes in the HPA axis are not only linked to the maturation of offensive responses but also determine the consequences of social stress. Combined, these studies in golden hamsters provide a novel mechanism for the development of agonistic behavior and suggest that age related differences in behavioral plasticity are mediated by the development of the HPA axis.

show abstract

Hormonal responses to fighting in hamsters: Separation of physical and psychological causes

Cited by 70 publications

References 12 publications

Recognition of Familiar Individuals in Golden Hamsters: A New Method and Functional Neuroanatomy

Recognition of Familiar Individuals in Golden Hamsters: A New Method and Functional Neuroanatomy

The Pharmacology of CP‐154,526, a Non‐Peptide Antagonist of the CRH1 Receptor: A Review

Stress, Aggression, and Puberty: Neuroendocrine Correlates of the Development of Agonistic Behavior in Golden Hamsters

Contact Info

Product

Resources

About